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Cancer

货号 产品名 CAS号 信息
CSN22566 Vorasidenib 1644545-52-7 Vorasidenib is an isocitrate dehydrogenase (IDH) inhibitor.
CSN22468 MOZ-IN-2 2055397-88-9 MOZ-IN-2 is an inhibitor of protein MOZ, a member of histone acetyltransferases, with an IC50 of 125 μM.
CSN22526 Tucidinostat 1616493-44-7 Tucidinostat is an inhibitor of HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor with IC50s of 95, 160, 67 and 78 nM, espectively.
CSN22506 SJ000291942 425613-09-8 SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules.
CSN22425 GSTO-IN-2 1202710-57-3 GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.
CSN22449 LLY-283 2040291-27-6 LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity.
CSN22427 HaloPROTAC 2 1799506-06-1 HaloPROTAC 2 is a PROTAC block consist of VH032 and a linker with chlorine functional group for conjugation reactions.
CSN22399 Tinodasertib 1464151-33-4 ETC-206 is a selective MNK1 and MNK2 inhibitor with IC50s of 64 nM and 86 nM, respectively.
CSN22492 Boc-C1-PEG2-C4-Cl 1835705-53-7 PROTAC Linker 1 is a linker used to link the warhead and the E3 ligase ligand.
CSN22505 SHIN1 2146095-85-2 SHIN1 is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.
CSN22467 WM-1119 2055397-28-7 MOZ-IN-1 is an inhibitor of MOZ which is a member of histone acetyltransferases with IC50 of 0.051 μM.
CSN22532 Vecabrutinib 1510829-06-7 Vecabrutinib is a potent BTK inhibitor, with IC50s of 4.6 nM and 1.1 nM for WT BTK and C481S BTK, respectively, and also inhibits ITK activity (IC50, 24 nM).
CSN22485 PF-06459988 1428774-45-1 PF-06459988 is an irreversible inhibitor of T790M-Containing EGFR Mutants.
CSN22428 Hesperin 4430-35-7 Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an Nrf2 activator.
CSN22507 SLV-2436 2095704-43-9 SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8  nM and 5.4 nM, respectively.
CSN22412 5-(3-Hydroxy-5-methoxyphenethyl)-2-methoxyphenol 67884-30-4 Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.
CSN22456 M443 1820684-31-8 M443 is an irreversible and specific inhibitor of MRK, with an IC50<125 nM.
CSN22432 TNP 519178-28-0 IP3K Inhibitor is a IP3K inhibitor with an IC50 of 10.2 μM.
CSN22436 JNJ-38877618 943540-74-7 JNJ-38877618 is a potent, highly selective, orally bioavailable Met kinase inhibitor with IC50s of 2 and 3 nM for wild type and mutant Met, respectively.
CSN22508 SM 16 614749-78-9 SM 16 is an an ATP-competitive ALK5/ALK4 inhibitor with IC50 value between 160 and 620 nM for inhibition of TGF-β1-induced Smad2/3 phosphorylation in cell study.
CSN22385 DDR-TRK-1 1934246-19-1 DDR1-IN-3 is a selective Discoidin Domain Receptor 1 (DDR1) inhibitor, with an IC50 value of 9.4 nM.
CSN22386 Dihydromunduletone 674786-20-0 Dihydromunduletone is a selective adhesion G protein–coupled receptor antagonist (aGPR) with an IC50 of ~21 μM.
CSN22378 c-Met-IN-2 1635406-73-3 c-Met-IN-2 is a potent, selective and orally available c-Met inhibitor, with an IC50 of 0.6 nM, with antitumor activity.
CSN22426 GW6471 880635-03-0 GW 6471 is a potent PPARα antagonist.
CSN22392 EGFR-IN-2 1643497-70-4 EGFR-IN-2 is a a noncovalent, irreversible, mutant-selective second generation EGFR inhibitor.
CSN22379 CDK12-IN-3 2220184-50-7 CMPD 7 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.
CSN22368 CDK8-IN-4 1613638-82-6 CDK8-IN-4 is an inhibitor of CDK8 extracted from patent WO2014090692A1, compound example 16, with an IC50 of 0.2 nM.
CSN22430 Indotecan 915303-09-2 Indotecan is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.
CSN22406 FT827 1959537-86-0 FT827 is a selective and covalent ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 52 nM.
CSN22460 MAT2A inhibitor 1 2201057-10-3 MAT2A inhibitor is a methionine adenosyltransferase 2A (MATA2) inhibitor.
CSN22395 EPAC 5376753 302826-61-5 EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.
CSN22484 2-Keto Crizotinib 1415558-82-5 PF-06260182 is a lactam metabolite of crizotinib.
CSN22451 LY 222306 154446-98-7 LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.
CSN22462 Mcl1-IN-4 1580484-04-3 Mcl1-IN-4 is an inhibitor of Mcl1 with an IC50 of 0.2 μM.
CSN22441 KO-947 1695533-89-1 KO-947 is a potent and selective inhibitor of ERK1/2 kinases with potential clinical utility in MAPK pathway dysregulated tumors.
CSN22521 TNF-α-IN-1 444287-49-4 TNF-α-IN-1 is a TNF-α inhibitor extracted from patent US20030096841A1, compound example I-7.
CSN22453 LY309887 127228-54-0 LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity.
CSN22422 GSK 4027 2079896-25-4 GSK 4027 is a chemical probe for the PCAF/GCN5 bromodomain with an pIC50 of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
CSN22480 Parsaclisib 1426698-88-5 Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
CSN22466 ML132 1230628-71-3 ML132 is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM.
CSN22528 UAA crosslinker 1 1167421-25-1 UAA crosslinker 1 act as substrates for pylRS/tRNA pair that enable its incorporation into a target protein.
CSN22515 SLF-amido-C2-COOH 1092369-24-8 PROTAC FKBP12-binding moiety 1 is a synthetic ligand for FKBP, used as a warhead ligand for conjugation reactions of PROTAC targeting on FKBP12.
CSN22516 PROTAC BRD9-binding moiety 1 2097512-23-5 PROTAC BRD9-binding moiety 1 is a I-BRD9-based warhead ligand for conjugation reactions of PROTAC targeting on BRD9.
CSN22473 Ebopiprant 2005486-31-5 OBE022 is an oral and selective prostaglandin F2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively.
CSN22517 N-Deshydroxyethyl Dasatinib 910297-51-7 PROTAC Bcr-Abl-binding moiety 1 is a Dasatinib-based warhead ligand for conjugation reactions of PROTAC targeting on Bcr-Abl.
CSN23328 (R)-N-(4-(3-Aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1196541-47-5 GDC-0575 is a potent and selective CHK1 inhibitor.
CSN23752 Elemicin 487-11-6 Elemicin is a phenylpropene with anticancer and antifungal activities, it exhibits anticholinergic-like effects in humans.
CSN23772 Thalidomide-O-amido-C8-NH2 1950635-15-0 Thalidomide-O-amido-C8-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN22491 4-(((6S,9S,9aS)-1-(Benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-2H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl dihydrogen phosphate 1422253-38-0 PRI-724 is a selective inhibitor of the CBP/β-catenin interaction.
CSN24156 E260 1241537-79-0 E260 is an inhibitor of the Fer/FerT kinase with Kd of 0.85 μM, selectively evokes metabolic stress and necrotic death in cancer cells.
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