优势价格
快速发货
品质保证
技术支持
400-920-2911 sales@csnpharm.cn
DOCK is a family of related proteins involved in intracellular signalling networks. DOCK family members contain a RhoGEF domain to function as guanine nucleotide exchange factors to promote GDP release and GTP binding to specific Small GTPases of the Rho family (e.g., Rac and Cdc42), leading to their activation since Rho proteins are inactive when bound to GDP but active when bound to GTP.
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN27204 | TBOPP | 1996629-79-8 | TBOPP is a selective DOCK1 inhibitor with IC50 value of 8.4μM. It dampened DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation. TBOPP treatment suppressed cancer metastasis and growth in vivo in mice. |
| CSN27183 | CPYPP | 310460-39-0 | CPYPP is a DOCK2 inhibitor which bounds to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro. It also inhibits DOCK1 and DOCK5 and exhibits selectivity over DOCK9. |
联系我们
官方电话：400-920-2911
二维码
微信公众号 CSN官网