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3C-like proteinase is a family of enzymes found in the Coronavirus polyprotein. It cleaves the polyprotein at two self-cleavage sites. It is a cysteine protease under clan PA, MEROPS classification C30. In coronaviruses, it is nonstructural protein number 5 (nsp5).
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12229 | Zanamivir | 139110-80-8 | Zanamivir is the first of two registered neuraminidase inhibitors for the treatment and prophylaxis of influenza. Zanamivir could inhibit SARS-CoV-2 3CLpro main protease. |
| CSN25593 | Theaflavin 3,3'-digallate | 30462-35-2 | Theaflavin-3,3'-digallate is a tea extract. Theaflavin-3,3'-digallate inhibited 3CLpro with IC50 value of 9.5μM in a fluorogenic substrate peptide assay. |
| CSN12034 | Tanshinone IIB | 17397-93-2 | Tanshinone IIB (TSB), a natural product isolated and purified from the roots of Salvia miltiorrhiza, can significantly inhibit the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner. Tanshinone IIB showed inhibitory effect on PL(pro) with IC50 value of 10.7μM and less inhibitory effect on 3CLpro with IC50 value of 24.8μM. |
| CSN13608 | Tanshinone IIA sulfonate sodium | 69659-80-9 | Tanshinone IIA sulfonate sodium is a water-soluble derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+entry (SOCE), and is used to treat cardiovascular disorders. |
| CSN19410 | Tanshinone IIA | 568-72-9 | Tanshinone IIA is a naturally occuring cardioprotective agent which can inhibit NF-κB and AP-1 DNA binding and display antioxidant and anti-inflammatory properties. Tanshinone IIA showed inhibitory effect on PL(pro) with IC50 value of 1.6μM and less inhibitory effect on 3CLpro with IC50 value of 89.1μM. |
| CSN12435 | Tanshinone I | 568-73-0 | Tanshinone I, an active principle isolated from the roots of Salvia miltiorrhiza (Danshen), is an inhibitor of type IIA human recombinant sPLA2 and rabbit recombinant cPLA2 with IC50s of 11 μM and 82 μM, respectively, is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I showed inhibitory effect on PL(pro) with IC50 value of 8.8μM and less inhibitory effect on 3CLpro with IC50 value of 38.7μM. |
| CSN25589 | Miltirone | 27210-57-7 | Rosmariquinone showed inhibitory effect on PL(pro) and 3CLpro with IC50 values of 30μM and 21.1μM, respectively. |
| CSN12572 | Rhoifolin | 17306-46-6 | Rhoifolin, a natural product isolated and purified from the leaves of Turpinia arguya Seem, hows monolithic proliferation inhibitory activities against Hela, A549 and MCF-7 cell lines, and may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro. |
| CSN19703 | Remdesivir | 1809249-37-3 | Remdesivir is an nucleotide-analog antiviral prodrug. Remdesivir could inhibit SARS-CoV-2 3CLpro main protease. |
| CSN28746 | Nirmatrelvir | 2628280-40-8 | PF-07321332 is an orally active 3CL protease inhibitor, binding covalently and directly to the catalytic cysteine (Cys145) residue of the enzyme. It works as an anti-SARS-CoV-2 drug. |
| CSN25590 | (S)-Methyl 1,6-dimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-6-carboxylate | 18887-19-9 | Methyl tanshinonate showed inhibitory effect on PL(pro) with IC50 value of 9.2μM and less inhibitory effect on 3CLpro with IC50 value of 21.1μM. |
| CSN16383 | Hesperetin | 520-33-2 | Hesperetin is a flavanone extracted from the peel of citrus that exhibits inhibition of PDE4 and UGT. Hesperetin has antioxidative and anti-inflammatory effects as well. Hesperetin dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 8.3μM in the cell-based assay. |
| CSN19988 | Herbacetin | 527-95-7 | Herbacetin, a natural product isolated and purified from the herbs of Equisetum hyemale L. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro. |
| CSN25342 | GC376 | 1416992-39-6 | GC376 is a 3CLpro (3C-like protease) inhibitor that shows promise in treating cats with certain presentations of FIP and has opened the door to targeted antiviral drug therapy. |
| CSN16500 | Dihydrotanshinone I | 87205-99-0 | Dihydrotanshinone I, a natural product isolated and purified from the roots of Salvia miltiorrhiza Bge., exhibits dose-dependent inhibition towards HLM-catalyzed propofol glucuronidation. Dihydrotanshinone I showed inhibitory effect on PL(pro) with IC50 value of 4.9μM and less inhibitory effect on 3CLpro with IC50 value of 14.4μM. |
| CSN16361 | Cryptotanshinone | 35825-57-1 | Cryptotanshinone is a potent STAT3 inhibitor (IC50 =4.6 μM) and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Cryptotanshinone showed inhibitory effect on PL(pro) with IC50 value of 0.8μM and slight inhibitory effect on 3CLpro with IC50 value of 226.7μM. |
| CSN50790 | CCF0058981 | 2708934-53-4 | CCF0058981 is a ML300-derived, non-covalent SARS-CoV‑2 3CLpro inhibitor. |
| CSN17350 | Aloe-emodin | 481-72-1 | Aloe-emodin, a natural product isolated and purified from the root of Rheum palmatum L. with a specific in vitro and in vivo anti-neuroectodermal tumor activity, reduces the toxicity and ROS induced by both monomeric and oligomeric Aβ species, appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation and has a strong non-carcinogenic stimulant-laxative action when applied to the skin, although it may increase the carcinogenicity of some kind of radiation. Aloe-Emodine dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 366μM in the cell-based assay. |
| CSN25594 | 3-isotheaflavin-3-gallate | 220473-67-6 | 3-isotheaflavin-3-gallate is a tea extract. It inhibited 3CLpro with IC50 value of 7μM in a fluorogenic substrate peptide assay. |
| CSN27868 | 16-(S)-ML188 | 1417700-12-9 | 16-(S)-ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with good enzyme and antiviral inhibitory activity. |
| CSN35888 | (±)-Alliin | 17795-26-5 | |
| CSN50497 | Lufotrelvir | 2468015-78-1 | |
| CSN61906 | Ledipasvir-d6 | 2050041-12-6 | |
| CSN62232 | Niazinin | 147821-57-6 | |
| CSN62389 | (Rac)-X77 | 2144491-78-9 | |
| CSN62313 | Ritonavir-d6 | 1616968-73-0 | |
| CSN62375 | SARS-CoV-2-IN-10 | 2722634-95-7 | |
| CSN51374 | Ensitrelvir | 2647530-73-0 | |
| CSN51375 | Ensitrelvir fumarate | 2757470-18-9 | |
| CSN64922 | YH-53 | 1471484-62-4 | |
| CSN65007 | Silymarin | 65666-07-1 | |
| CSN67369 | X77 | 2455518-33-7 | |
| CSN67707 | SARS-CoV MPro-IN-1 | 2413716-71-7 | |
| CSN68344 | Lopinavir-d8 | 1224729-35-4 | |
| CSN68548 | SDZ 224-015 | 161511-45-1 | |
| CSN68949 | SARS-CoV-2-IN-11 | 2722635-28-9 | |
| CSN73846 | INSCoV-614(1B) | 2735704-33-1 | |
| CSN73852 | INSCoV-601I(1) | 2735704-19-3 | |
| CSN73851 | INSCoV-600K(1) | 2735704-15-9 | |
| CSN77866 | Hydroxyethylamine | 1418733-36-4 | |
| CSN77859 | SARS-CoV-2 Mpro-IN-1 | 2758359-91-8 | |
| CSN78437 | SARS-CoV MPro-IN-2 | 81418-42-0 | |
| CSN78233 | Mpro/PLpro-IN-1 | 2766185-78-6 | |
| CSN78989 | Antiviral agent 5 | 2698336-82-0 | |
| CSN79117 | 3CPLro-IN-2 | 2758278-51-0 | |
| CSN79168 | 3CPLro-IN-1 | 2432956-06-2 | |
| CSN80638 | SARS-CoV-2 3CLpro-IN-3 | 2505241-13-2 | |
| CSN90043 | SARS-CoV-2 3CLpro-IN-2 | 2765088-93-3 | |
| CSN95895 | (R)-2-Methoxy-3-(octadecyloxy)propyl ((1S,2R,3S,4R,6R)-2,3,4-trihydroxy-6-methoxycyclohexyl) hydrogen phosphate | 701976-54-7 | |
| CSN107754 | (3S,6S,9S,12S,E)-Benzyl 9-isobutyl-6-isopropyl-3-methyl-1-(5-methylisoxazol-3-yl)-1,4,7,10-tetraoxo-12-(((S)-2-oxopyrrolidin-3-yl)methyl)-2,5,8,11-tetraazapentadec-13-en-15-oate | 884650-98-0 |
