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3C-like proteinase is a family of enzymes found in the Coronavirus polyprotein. It cleaves the polyprotein at two self-cleavage sites. It is a cysteine protease under clan PA, MEROPS classification C30. In coronaviruses, it is nonstructural protein number 5 (nsp5).
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN11897 | Saquinavir Mesylate | 149845-06-7 | Saquinavir mesylate is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir could inhibit SARS-CoV-2 3CLpro main protease. |
| CSN11896 | Saquinavir | 127779-20-8 | Saquinavir is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir could inhibit SARS-CoV-2 3CLpro main protease. |
| CSN25605 | Rupintrivir | 223537-30-2 | Rupintrivir is a novel human Rhinovirus 3C Protease inhibitor and exhibited antiviral activity against HRV clinical isolates and HEV a mean EC50 of 24 nM (range, 3 to 104 nM) and a mean EC50 of 41 nM (range, 7 to 137 nM), respectively, in H1-HeLa cell protection assays. |
| CSN11664 | Pectolinarin | 28978-02-1 | Pectolinarigenin, a natural product isolated and purified from the herbs of Cirsium japonicum DC., possesses hepatoprotective and anti-inflammatory activity. |
| CSN11198 | Indinavir | 150378-17-9 | Indinavir is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability. Indinavir could inhibit SARS-CoV-2 3CLpro main protease. |
| CSN25611 | (((1,4-Phenylenebis(azanediyl))bis(carbonyl))bis(3-nitro-5,1-phenylene))diboronic acid | 693235-40-4 | FL-166 inhibited SARS-associated 3CLpro with Ki value of 0.04μM. |
| CSN25610 | (((1,4-Phenylenebis(oxy))bis(carbonyl))bis(3-nitro-5,1-phenylene))diboronic acid | 693235-36-8 | FL-078 inhibited SARS-associated 3CLpro with Ki value of 4.5μM. |
| CSN10460 | Bis(diethylthiocarbamoyl) disulfide | 97-77-8 | Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram acts as an allosteric inhibitor of MERS-CoV PLpro but as a competitive (or mixed) inhibitor of SARS-CoV PLpro. It also inhibits pyroptosis by blocking gasdermin D pore formation. |
| CSN25607 | Dieckol | 88095-77-6 | Dieckol exhibited SARS-CoV 3CL(pro) trans/cis-cleavage inhibitory effects with IC50 values of 2.7 and 68.1 μM, respectively. It formed extremely strong hydrogen bonds to the catalytic dyad (Cys145 and His41) of the SARS-CoV 3CL(pro). |
| CSN25612 | GRL-0496 | 1087243-14-8 | CE-5 blocks MERS-CoV 3CLpro activity with EC50 value of ∼12.5 μM. It inhibited SARS 3CLpro activity with IC50 value of 30nM and exhibited antiviral effect with EC50 value of 6.9μM. |
| CSN10276 | 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 1617-53-4 | Amentoflavone is an inhibitor of human UDP-glucuronosyltransferases with anti-inflammatory, antioxidative, and neuroprotective effects and it can be isolated from the seeds of Ginkgo biloba L. Amentoflavone inhibited SARS-CoV 3CL(pro) with IC50 value of 8.3μM. |
| CSN25601 | 3-Ethyl-2-(3-(3-((3-ethylbenzo[d]thiazol-2(3H)-ylidene)methyl)-5-methylcyclohex-2-en-1-ylidene)prop-1-en-1-yl)benzo[d]thiazol-3-ium | 393540-75-5 | A38120 is a 3CLpro inhibitor with IC50 values of 2 ± 0.4μM and 11.9 ± 3.5μM for 3CLpro of SARS and TGEV, respectively. |
| CSN25603 | 2-(5-Bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)-2-fluoroethanone | 1348639-12-2 | 3CLpro inhibitor 12d inhibited SARS 3CLpro with IC50 value of 28μM. |
| CSN25602 | 2-(5-Bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)ethanone | 1349571-70-5 | 3CLpro inhibitor 11d inhibited SARS 3CLpro with IC50 value of 13μM. |
| CSN25592 | SARS-CoV-2-IN-1 | 2412965-59-2 | 3CLpro inhibitor compound 13b inhibited the purified recombinant SARS-CoV2 3CLpro with IC50 value of 0.67 ± 0.18μM. Also it inhibitied the SARS-CoV 3CLpro and the MERS-CoV 3CLpro with IC50 values of 0.90 ± 0.29μM and 0.58 ± 0.22μM, respectively. It binds the substrate-binding cleft of 3CLpro. |
| CSN25600 | 1-Methyl-5-((4-methylpiperidin-1-yl)sulfonyl)indoline-2,3-dione | 1529815-13-1 | 3CLpro inhibitor 8k1 is an isatin-derived SARS-CoV 3CL(pro) inhibitor with IC50 value of 1.04μM measued by in vitro protease assay using fluorogenic substrate peptide. |
| CSN25599 | N-(3-((3-(Dimethylamino)propyl)amino)-1-(5-(2-nitrophenyl)furan-2-yl)-3-oxoprop-1-en-2-yl)-4-methylbenzamide | 384369-45-3 | 3CLpro inhibitor 7 is a competitive inhibitor of 3CLpro with Ki value of 9.93 ± 0.44μM. It interacts with amino acid residues in the active site of 3CLpro through hydrophobic and hydrogen bond. |
| CSN25637 | (E)-3-(4-Chloro-2-fluorophenyl)-N-((S)-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-3-phenylpropan-2-yl)acrylamide | 1065478-52-5 | 3CLpro inhibitor 6d is a peptidomimetic inhibitor of enterovirus 3Cpro. It also inhibited MERS-CoV 3CLpro and SARS-CoV 3CLpro with IC50 values ranging from 1.7 to 4.7 μM and from 0.2 to 0.7 μM, respectively. |
| CSN25598 | N-(3-((3-(Dimethylamino)propyl)amino)-1-(5-(3-nitrophenyl)furan-2-yl)-3-oxoprop-1-en-2-yl)-4-methylbenzamide | 324566-35-0 | 3CLpro inhibitor 6 is a competitive inhibitor of 3CLpro with Ki value of 9.11± 1.61μM. It interacts with amino acid residues in the active site of 3CLpro through hydrophobic and hydrogen bond. |
| CSN25609 | (E)-4-Chloro-2-(5-((1-(4-fluorophenyl)-5-oxo-3-phenyl-1H-pyrazol-4(5H)-ylidene)methyl)furan-2-yl)benzoic acid | 1945974-05-9 | 3CLpro inhibitor 3g could inhibit H5N1 neuraminidase with IC50 of 2.9μM, as well as inhibited SARS 3CLpro and MERS 3CLpro with IC50 values of 20.2 ± 0.3μM and 10.1 ± 1.8μM, respectively. |
| CSN25608 | (E)-2-(5-((1-(3-Carboxyphenyl)-5-oxo-3-phenyl-1H-pyrazol-4(5H)-ylidene)methyl)furan-2-yl)-4-chlorobenzoic acid | 1945974-03-7 | 3CLpro inhibitor 3f could inhibit H5N1 neuraminidase with IC50 of 2.8μM, as well as inhibited SARS 3CLpro and MERS 3CLpro with IC50 values of 16.4 ± 0.7μM and 12.2 ± 2.2μM, respectively. |
| CSN25604 | 3CLpro inhibitor 14 | 2993-05-7 | 3CLpro inhibitor 14 is a 3CLpro inhibitor with IC50 value of 13.9 ± 2.2μM (SARS‐CoV 3CLpro). |
| CSN25591 | ML188 | 1417700-13-0 | 16-(R)-ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with good enzyme and antiviral inhibitory activity. |
