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5-HT Receptor

5-HT Receptor

货号 产品名 CAS号 信息
CSN12199 Vilazodone 163521-12-8 Vilazodone is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
CSN23171 Tropanserin 85181-40-4 Tropanserin is a selective 5-HT3 receptor antagonist.
CSN27240 Tianeptine 66981-73-5 Tianeptine is an atypical antidepressant drug. It decreases serotonin's activity and amount in serotonergic synapses of the central nervous system by increasing serotonin reuptake.
CSN12086 Tiamenidine 31428-61-2 Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis, shows D4 selectivity or serotonin antagonism.
CSN23114 SGS 518 Oxalate 445441-27-0 Selective 5-HT6 antagonist
CSN23197 WAY 629 HCl 57756-44-2 Selective 5-HT2C agonist
CSN23140 Tandospirone HCl 99095-10-0 Selective 5-HT1A partial agonist
CSN23208 Zimelidine 2HCl 60525-15-7 Selective 5-HT uptake inhibitor
CSN23095 SB 215505 162100-15-4 SB215505 is a potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). It Increases wakefulness and motor activity in rats.
CSN23104 SB 399885 HCl 402713-81-9 SB-399885 hydrochloride is a 5-HT6 receptor antagonist.
CSN23105 SB 699551 864741-95-7 SB 699551 is a selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively).
CSN23098 SB 243213 HCl 200940-23-4 SB 243213 hydrochloride is a selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile[1].
CSN23096 SB 221284 196965-14-7 SB 221284 is potent, selective 5-HT2C/2B receptor antagonist. SB 221284 are pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 2B and 2C receptors respectively.
CSN17113 Promethazine HCl 58-33-3 Promethazine HCl is the effective antagonist of the H1 receptor and moderate antagonist of mACh receptor.
CSN23130 SR 57227 HCl 77145-61-0 Potent and selective 5-HT3 agonist
CSN27301 Phenylbiguanide 102-02-3 Phenylbiguanide is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM.
CSN18173 Pardoprunox HCl 269718-83-4 Pardoprunox HCl is a partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist.
CSN27393 Paliperidone palmitate 199739-10-1 Paliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester prodrug of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia.
CSN27188 p-MPPI HCl 220643-77-6 p-MPPI is a novel 5-HT Receptor 1A receptor antagonist. It produced a significant and dose-related anxiolytic profile in male mice.
CSN27303 Org-12962   132834-56-1 Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety.
CSN23228 NPS ALX Compound 4a 2HCl 1781934-44-8 NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM .
CSN26151 LY344864 racemate 186543-64-6 LY344864 racemate is the racemate form of LY344864. LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
CSN21789 Perospirone HCl 3H2O 129273-38-7 In CHO cells expressing human 5-HT1A receptors, perospirone shows a high affinity (Ki = 0.72 nM), and exhibits partial agonistic efficacy.
CSN14586 Galanolactone 115753-79-2 Galanolactone, a natural product isolated and purified from the rhizomes of Zingiber officinale Roscoe with cytotoxic activity, has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes, and inhibits nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM.
CSN25658 Elopiprazole 115464-77-2 Elopiprazole is an antipsychotic drug of the phenylpiperazine class.
CSN27302 Dehydroaripiprazole   129722-25-4 Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole.
CSN17079 Colfosceril Palmitate 63-89-8 Colfosceril palmitate is a drug used as a pulmonary surfactant. It is also a key conponent of LNP as an effective delivery vehicle of mRNA.
CSN24980 5-Methoxytryptamine 608-07-1 5-Methoxytryptamine is a tryptamine derivative that acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors.
CSN23078 RS 67506 HCl 168986-61-6 5-HT4 partial agonist
CSN23074 RS 23597-190 HCl 149719-06-2 5-HT4 antagonist
CSN23076 RS 39604 HCl 167710-87-4 5-HT4 antagonist
CSN23090 SB 200646 HCl 143797-62-0 5-HT2C/2B antagonist
CSN23080 RU 24969 Hemisuccinate 66611-27-6 5-HT1A and 5-HT1B agonist
CSN27304 2-Methyl-5-HT 78263-90-8 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects.
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