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5-HT Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12199 | Vilazodone | 163521-12-8 | Vilazodone is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
| CSN23171 | Tropanserin | 85181-40-4 | Tropanserin is a selective 5-HT3 receptor antagonist. |
| CSN27240 | Tianeptine | 66981-73-5 | Tianeptine is an atypical antidepressant drug. It decreases serotonin's activity and amount in serotonergic synapses of the central nervous system by increasing serotonin reuptake. |
| CSN12086 | Tiamenidine | 31428-61-2 | Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis, shows D4 selectivity or serotonin antagonism. |
| CSN23197 | WAY 629 HCl | 57756-44-2 | Selective 5-HT2C agonist |
| CSN23140 | Tandospirone HCl | 99095-10-0 | Selective 5-HT1A partial agonist |
| CSN23208 | Zimelidine 2HCl | 60525-15-7 | Selective 5-HT uptake inhibitor |
| CSN23095 | SB 215505 | 162100-15-4 | SB215505 is a potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). It Increases wakefulness and motor activity in rats. |
| CSN23105 | SB 699551 | 864741-95-7 | SB 699551 is a selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively). |
| CSN23096 | SB 221284 | 196965-14-7 | SB 221284 is potent, selective 5-HT2C/2B receptor antagonist. SB 221284 are pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 2B and 2C receptors respectively. |
| CSN17113 | Promethazine HCl | 58-33-3 | Promethazine HCl is the effective antagonist of the H1 receptor and moderate antagonist of mACh receptor. |
| CSN23130 | SR 57227 HCl | 77145-61-0 | Potent and selective 5-HT3 agonist |
| CSN27301 | Phenylbiguanide | 102-02-3 | Phenylbiguanide is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM. |
| CSN18173 | Pardoprunox HCl | 269718-83-4 | Pardoprunox HCl is a partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist. |
| CSN27393 | Paliperidone palmitate | 199739-10-1 | Paliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester prodrug of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia. |
| CSN27188 | p-MPPI HCl | 220643-77-6 | p-MPPI is a novel 5-HT Receptor 1A receptor antagonist. It produced a significant and dose-related anxiolytic profile in male mice. |
| CSN27303 | Org-12962 | 132834-56-1 | Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety. |
| CSN26151 | LY344864 racemate | 186543-64-6 | LY344864 racemate is the racemate form of LY344864. LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor. |
| CSN14586 | Galanolactone | 115753-79-2 | Galanolactone, a natural product isolated and purified from the rhizomes of Zingiber officinale Roscoe with cytotoxic activity, has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes, and inhibits nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. |
| CSN25658 | Elopiprazole | 115464-77-2 | Elopiprazole is an antipsychotic drug of the phenylpiperazine class. |
| CSN27302 | Dehydroaripiprazole | 129722-25-4 | Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole. |
| CSN23783 | AVN492 | 1220646-23-0 | AVN492 is a selective antagonist of 5-HT6R with Ki of 91 pM. |
| CSN24980 | 5-Methoxytryptamine | 608-07-1 | 5-Methoxytryptamine is a tryptamine derivative that acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors. |
| CSN23078 | RS 67506 HCl | 168986-61-6 | 5-HT4 partial agonist |
| CSN23074 | RS 23597-190 HCl | 149719-06-2 | 5-HT4 antagonist |
| CSN23076 | RS 39604 HCl | 167710-87-4 | 5-HT4 antagonist |
| CSN23090 | SB 200646 HCl | 143797-62-0 | 5-HT2C/2B antagonist |
| CSN23080 | RU 24969 Hemisuccinate | 66611-27-6 | 5-HT1A and 5-HT1B agonist |
| CSN27304 | 2-Methyl-5-HT | 78263-90-8 | 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects. |
