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5-HT Receptor
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN23195 | WAY208466 2HCl | 1207064-61-6 | WAY-208466 2HCl is a selective serotonin 5-HT6 receptor agonist. |
CSN12199 | Vilazodone | 163521-12-8 | Vilazodone is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
CSN23171 | Tropanserin | 85181-40-4 | Tropanserin is a selective 5-HT3 receptor antagonist. |
CSN12086 | Tiamenidine | 31428-61-2 | Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis, shows D4 selectivity or serotonin antagonism. |
CSN23100 | SB 258719 HCl | 1217674-10-6 | Selective 5-HT7 antagonist |
CSN23114 | SGS518 oxalate | 445441-27-0 | Selective 5-HT6 antagonist |
CSN23197 | WAY 629 hydrochloride | 57756-44-2 | Selective 5-HT2C agonist |
CSN23140 | Tandospirone HCl | 99095-10-0 | Selective 5-HT1A partial agonist |
CSN23208 | Zimelidine dihydrochloride | 60525-15-7 | Selective 5-HT uptake inhibitor |
CSN23095 | SB-215505 | 162100-15-4 | SB215505 is a potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). It Increases wakefulness and motor activity in rats. |
CSN23104 | SB-399885 HCl | 402713-81-9 | SB-399885 hydrochloride is a 5-HT6 receptor antagonist. |
CSN23105 | SB 699551 dihydrochloride | 864741-95-7 | SB 699551 is a selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively). |
CSN23098 | SB 243213 HCl | 200940-23-4 | SB 243213 hydrochloride is a selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile[1]. |
CSN23096 | SB-221284 | 196965-14-7 | SB 221284 is potent, selective 5-HT2C/2B receptor antagonist. SB 221284 are pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 2B and 2C receptors respectively. |
CSN23094 | SB 206553 HCl | 1197334-04-5 | SB 206553 HCl is a potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92). It displays > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pKi < 6). |
CSN23093 | SB 204741 | 152239-46-8 | SB 204741 is potent and selective 5-HT2B receptor antagonist (pA2 = 7.95). It displays ≥ 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi < 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors. |
CSN17113 | Promethazine HCl | 58-33-3 | Promethazine HCl is the effective antagonist of the H1 receptor and moderate antagonist of mACh receptor. |
CSN23099 | SB-258585 hydrochloride | 1216468-02-8 | Potent, selective 5-HT6 antagonist |
CSN23130 | SR 57227A | 77145-61-0 | Potent and selective 5-HT3 agonist |
CSN27301 | Phenylbiguanide | 102-02-3 | Phenylbiguanide is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM. |
CSN18173 | Pardoprunox HCl | 269718-83-4 | Pardoprunox HCl is a partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist. |
CSN27188 | p-MPPI HCl | 220643-77-6 | p-MPPI is a novel 5-HT Receptor 1A receptor antagonist. It produced a significant and dose-related anxiolytic profile in male mice. |
CSN27303 | Org-12962 | 132834-56-1 | Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety. |
CSN23228 | NPS ALX Compound 4a 2HCl | 1781934-44-8 | NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM . |
CSN26151 | LY 344864 racemate | 186543-64-6 | LY344864 racemate is the racemate form of LY344864. LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor. |
CSN23273 | Lecozotan | 434283-16-6 | Lecozotan is a potent and selective 5-HT(1A) receptor antagonist. It significantly potentiated the potassium chloride-stimulated release of glutamate and acetylcholine in the dentate gyrus of the hippocampus. It produced a significant improvement in task performance efficiency at an optimal dose (1 mg/kg p.o.) in aged rhesus monkeys. |
CSN21789 | Perospirone HCl | 129273-38-7 | In CHO cells expressing human 5-HT1A receptors, perospirone shows a high affinity (Ki = 0.72 nM), and exhibits partial agonistic efficacy. |
CSN23084 | S-14506 HCl | 286369-38-8 | Highly potent 5-HT1A agonist; displays unique binding mechanism |
CSN23194 | WAY-181187 oxalate | 1883548-85-3 | High affinity and selective 5-HT6 agonist |
CSN14586 | Galanolactone | 115753-79-2 | Galanolactone, a natural product isolated and purified from the rhizomes of Zingiber officinale Roscoe with cytotoxic activity, has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes, and inhibits nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. |
CSN24769 | F-15599 | 635323-95-4 | F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist with Ki value of 3.4nM. |
CSN25658 | Elopiprazole | 115464-77-2 | Elopiprazole is an antipsychotic drug of the phenylpiperazine class. |
CSN27302 | Dehydroaripiprazole | 129722-25-4 | Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole. |
CSN23783 | AVN-492 | 1220646-23-0 | AVN492 is a selective antagonist of 5-HT6R with Ki of 91 pM. |
CSN24980 | 2-(5-Methoxy-1H-indol-3-yl)ethanamine | 608-07-1 | 5-Methoxytryptamine is a tryptamine derivative that acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors. |
CSN23078 | RS 67506 HCl | 168986-61-6 | 5-HT4 partial agonist |
CSN23074 | RS 23597-190 | 149719-06-2 | 5-HT4 antagonist |
CSN23090 | SB-200646A | 143797-62-0 | 5-HT2C/2B antagonist |
CSN23085 | S 32212 hydrochloride | 847871-78-7 | 5-HT2C inverse agonist; α2-adrenoceptor antagonist |
CSN27304 | 2-Methyl-5-HT | 78263-90-8 | 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects. |