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| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN10004 | (2R,3S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol | 4291-63-8 | Cladribine is an adenosine deaminase inhibitor used to treat hairy cell leukemia and multiple sclerosis. For U266, RPMI8226, and MM1.S cells, its IC50 |
| CSN10240 | (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide | 173334-57-1 | Aliskiren is a renin inhibitor with IC50 of 1.5 nM. |
| CSN10349 | 1,14-Dimethyl (3S,8S,9S,12S)-3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pentaazatetradecanedioate | 198904-31-3 | Atazanavir is a protease inhibitor used as an antiretroviral medication to treat and prevent HIV/AIDS. |
| CSN10369 | 2-Ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid | 147403-03-0 | Azilsartan is an orally available angiotensin II type 1 (AT1) receptor antagonist with IC50 value of 2.6 nM. |
| CSN10496 | (S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid | 177036-94-1 | Ambrisentan is an oral, once-daily endothelin receptor antagonist that is selective for the endothelin type A receptor (IC50s = 0.251, 0.316, 0.398, 2 |
| CSN10538 | Phenethyl 3-(3,4-dihydroxyphenyl)acrylate | 104594-70-9 | Caffeic acid phenethyl ester, a natural product isolated and purified from the barks of Cinnamomum cassia Presl, is a potent and specific inhibitor of |
| CSN10852 | 2-(5,6-Dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid | 117570-53-3 | DMXAA is an apoptosis inducer with anti-vascular activity. It is mSTING agonist, selective for mouse STING over human STING. It Induces IFN-β and cyto |
| CSN10931 | 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline | 183321-74-6 | Erlotinib is an EGFR inhibitor with IC50 of 2 nM, > 1000-fold more sensitive for EGFR than human c-Src or v-Abl. |
| CSN11084 | N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine | 184475-35-2 | Gefitinibis an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respe |
| CSN11131 | 2-Chloro-5-nitro-N-phenylbenzamide | 22978-25-2 | GW9662 selectively antagonizes PPARγ with IC50 of 3.3 nM. It can inhibit the growth of mammary cancer cells. |
| CSN11187 | (R)-N1-((S)-3-(1H-Indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide | 142880-36-2 | GM6001 is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3 |
| CSN11190 | N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide | 152459-95-5 | Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. |
| CSN11280 | 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione | 191732-72-6 | Lenalidomide, a analog of thalidomide, is TNF-α secretion inhibitor with IC50 of 13 nM. |
| CSN11339 | 7-((1R,2R,3R)-2-(4,4-Difluoro-3-oxooctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic acid | 136790-76-6 | Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation. |
| CSN11455 | Sodium (R,E)-2-(1-(((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)thio)methyl)cyclopropyl)acetate | 151767-02-1 | Montelukast Sodium is a potent, selective and competitive LTR1 antagonist with IC50 value < 5 nM, possesssing anti-inflammatory and bronchodilating ac |
| CSN11667 | (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid | 137281-23-3 | Pemetrexed is an antifolate and antimetabolite for TS(thymidylate synthase), DHFR(dihydrofolate reductase) and GARFT(glycinamide ribonucleotide formyl |
| CSN11857 | 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide | 162401-32-3 | Roflumilast is a selective and long-acting inhibitor of PDE-4 with IC50 of 0.8 nM. |
| CSN11862 | (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol | 186692-46-6 | Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM and shows little effect on CDK4/6 |
| CSN11899 | 4-(5-(4-Fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl)pyridine | 152121-47-6 | SB-203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM. |
| CSN12170 | (E)-2-Cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide | 148741-30-4 | Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR. |
| CSN12304 | 4-Iodo-3-nitrobenzamide | 160003-66-7 | BSI-201 is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). |
| CSN12327 | 6,9-Bis((2-aminoethyl)amino)benzo[g]isoquinoline-5,10-dione dimaleate | 144675-97-8 | Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Pixantrone dimaleate is an experimental antineopl |
| CSN12330 | (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol | 10083-24-6 | Piceatannol, a natural stilbene, is selective Syk inhibitor extracted from the rhizomes of Polygonum cuspidatum Sieb. et Zucc.. |
| CSN12357 | N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine | 153436-54-5 | PD153035 is EGFR inhibitor with Ki and IC50 of 5.2 pM and 29 pM and could rapidly suppress autophosphorylation of EGFR. |
| CSN12358 | N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine | 153436-53-4 | AG-1478 selectively inhibits EGFR with IC50 of 3 nM in cell-free assay. |
| CSN12447 | (2S,3S,4R,5R,6R)-6-(((2R,3R,4R,5R,6R)-6-(((2R,3S,4S,5R,6R)-2-Carboxy-4-hydroxy-6-(((2R,3S,4R,5R,6S)-4-hydroxy-6-methoxy-5-(sulfoamino)-2-((sulfooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-5-(sulfooxy)tetrahydro-2H-pyran-3-yl)oxy)-5-(sulfoamino)-4-(sulfooxy)-2-((sulfooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-3-(((2R,3R,4R,5S,6R)-4,5-dihydroxy-3-(sulfoamino)-6-((sulfooxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-2-carboxylic acid, decasodium salt | 114870-03-0 | Fondaparinux sodium is a pentasaccharide inhibitor of antithrombin-dependent factor Xa (IC50 = 40 nM). It can bind to antithrombin III. |
| CSN12489 | 5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride | 112529-15-4 | Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes. |
| CSN12500 | (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol | 117048-59-6 | Combretastatin A4 is a tubulin polymerization inhibitor with Kd value of 0.4 μM for binding to β-tubulin. |
| CSN12559 | (R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid | 147127-20-6 | Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucia |
| CSN12570 | 5-(4-(2-(Methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidine-2,4-dione maleate | 155141-29-0 | Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated recepto |
| CSN12700 | N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride | 183322-45-4 | PD153035 HCl is an reversible inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM. |
| CSN12964 | (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate | 183133-96-2 | Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel exerts it |
| CSN13185 | 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | 19171-19-8 | Pomalidomide can inhibit LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. |
| CSN13562 | 2-((3-Aminopyridin-2-yl)methylene)hydrazine-1-carbothioamide | 143621-35-6 | Triapine is a ribonucleotide reductase inhibitor and a CDK inhibtor. |
| CSN16276 | 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione | 198474-05-4 | PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor with IC50 of 0.41 μM. |
| CSN16424 | (E)-3-(4-Hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one | 58749-22-7 | Licochalcone A, an estrogenic flavanoid, can be an inhibitor of p-glycoprotein and has anti-inflammatory actions. |
| CSN16694 | 1,1-Dimethylbiguanide Hydrochloride | 1115-70-4 | Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by su |
| CSN16698 | Sodium hydrogen (4-amino-1-hydroxy-1-phosphonobutyl)phosphonate trihydrate | 121268-17-5 | Alendronate Sodium Trihydrate is an inhibitor of farnesyl diphosphate synthase with IC50 of 460 nM. It is used to treat osteoporosis. |
| CSN16708 | (R,Z)-3-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexan-1-ol | 19356-17-3 | Calcifediol is an active metabolite of vitamin D. It can inhibit the secretion of parathyroid hormone with 2 nM and commonly used as an indicator of b |
| CSN16716 | (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-((R)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)propan-2-yl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentaone | 159351-69-6 | Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM. |
| CSN16720 | 2-Amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride | 162359-56-0 | Fingolimod HCl is a S1P antagonist with IC50 of 0.033 nM. |
| CSN16725 | N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride | 183319-69-9 | Erlotinib HCl is a directly acting inhibitor of human EGFR tyrosine kinase with an IC50 of 2 nM. |
| CSN19413 | (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | 27208-80-6 | Polydatin, extracted from the roots ofPolygonum cuspidatumSieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in se |
| CSN19473 | 4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid | 153559-49-0 | Bexarotene is a selective agonist of RXRβ (IC50 = 24 nM), RXRγ (IC50 = 25 nM) and RXRα (IC50 = 33 nM) with antineoplastic activity. |
| CSN19160 | N-(2-((3-(4-Bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide dihydrochloride | 130964-39-5 | H 89 2HCl is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM. It also shows weak inhibit |
| CSN16987 | N-(2-((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide | 141430-65-1 | ABT-751 can inhibit microtubule polymerization through binding to β-tubulin on the colchine site. |
| CSN12943 | (2R,3S)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4,3-dihydroxy-2-isobutylsuccinamide | 154039-60-8 | Marimastat is a competitive and broad-spectrum MMP inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7, respe |
| CSN11329 | (S)-N-((2S,4S,5S)-5-(2-(2,6-Dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide | 192725-17-0 | Lopinavir is an antiretroviral of the protease inhibitor class, as well as an inhibitor of P-Glycoprotein, Cytochrome P450 3A and Organic Anion Transp |
| CSN13587 | Thiazol-5-ylmethyl ((2S,3S,5S)-3-hydroxy-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl)carbamate | 155213-67-5 | Ritonavir is both an HIV protease inhibitor and a Cytochrome P450 3A inhibitor. |
| CSN26140 | N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide | 1424635-83-5 | TRULI is an ATP-competitive inhibitor of Lats kinases. It is a potent, non-toxic, and reversible inhibitor of Hippo signaling which causes Yap-depende |
