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| 货号 | 产品名称 | CAS号 | 简介 |
|---|---|---|---|
| CSN20392 | Benzyl ((2S)-3-methyl-1-oxo-1-((1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate | 88191-84-8 | MDL28170 is a potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like seri |
| CSN26140 | N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide | 1424635-83-5 | TRULI is an ATP-competitive inhibitor of Lats kinases. It is a potent, non-toxic, and reversible inhibitor of Hippo signaling which causes Yap-depende |
| CSN26180 | 6-((Naphthalen-1-ylmethyl)thio)-7H-purine | 313984-77-9 | PU-02 is an antagonist of serotonin (5-HT) receptor subtype 5-HT3. |
| CSN27205 | 4-((4-Methoxyphenyl)diazenyl)-1H-pyrazole-3,5-diamine | 6975-75-3 | ILK-IN-3 is an integrin linked kinase inhibitor. |
| CSN27206 | 9-(2,4-Dihydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione | 117593-36-9 | CIL56 is a inducer of regulated, non-apoptotic cell death. It is a lead compound of FIN56, |
| CSN27211 | Bis(morpholinothiocarbonyl) disulfide | 729-46-4 | JX06 is a selective covalent PDK1 inhibitor with IC50 values of 49, 101 and 313nM for PDK-1, PDK-2 and PDK-3, respectively. |
| CSN27238 | 2-Methyl-2-(4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy)propanoic acid | 3771-19-5 | Nafenopin is a peroxisome proliferator that is used to promote liver tumors. It has been used as an antihyperlipoproteinemic agent. |
| CSN27244 | (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol | 6698-26-6 | 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine |
| CSN27600 | 1-Methyl-8-(4-(quinolin-2-ylmethoxy)phenoxy)-4,5-dihydro-1H-thieno[3,4-g]indazole-6-carboxamide | 364762-86-7 | TD-198946, a thienoindazole derivative, is a potent chondrogenic agent. |
| CSN26189 | 4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol | 68392-35-8 | Afimoxifene is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopre |
| CSN27722 | 2-(4-(3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile | 1825345-33-2 | AZ9482 is a PARP inhibitor with IC50 values of 1, 1, 46, 640, 9, and 160nM for PARP1, -2, -3, -6, TNKS1/PARP5a, and TNKS2, respectively. |
| CSN27723 | 4-Ethoxy-N-(5-nitrothiazol-2-yl)benzamide | 312608-54-1 | MID-1 is a MG53-IRS-1 interaction disruptor. It abolished MG53-mediated IRS-1 ubiquitination and degradation, as well as sensitized insulin signaling |
| CSN27735 | N-(3-Methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine | 827327-28-6 | MALAT1-IN-1 is a potent and specific Malat1 (Metastasis-associated lung adenocarcinoma transcript 1) inhibitor. |
| CSN27743 | 3-((4-(Methyl(4-(3-(4-(trifluoromethoxy)phenyl)ureido)phenyl)amino)pyrimidin-2-yl)amino)benzenesulfonamide | 579515-63-2 | GW806742X is an ATP mimetic MLKL inhibitor with Kd value of 9.3μM, and a VEGFR2 inhibitor with IC50 value of 2nM. |
| CSN27773 | 3-Bromo-N'-(1-(2,4-dihydroxyphenyl)ethylidene)-4-methylbenzohydrazide | 468747-17-3 | mTOR inhibitor-1 is an ATP-competitive inhibitor of mTOR. It suppressed A549 cell proliferation and induced autophagy. |
| CSN27768 | 1-(4-(2H-Tetrazol-5-yl)butyl)-4-(5H-dibenzo[a,d][7]annulen-5-ylidene)piperidine | 162640-98-4 | AT 56 is an orally active L-PGDS inhibitor with IC50 value of 95μM. It inhibits the production of PGD2 from PGH2 in vitro, with no effect on PG |
| CSN27779 | (E)-6-Fluoro-2-(2-(5-nitrofuran-2-yl)vinyl)-3-phenylquinazolin-4(3H)-one | 2374285-52-4 | CEBPα inducer 1 is a potent inducer of C/EBPα and myeloid differentiation. |
| CSN27841 | (Z)-5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one | 1558598-41-6 | PFM 01 is a MRE11 endonuclease inhibitor which can prevent double-stranded break resection. It enhances NHEJ and reduces homologous recombination. |
| CSN27839 | 4-Cyano-N-cyclopropyl-N-(thiophen-2-ylmethyl)benzamide | 1210906-48-1 | NSD2-PWWP1 antagonist 3f can bind to the NSD2-PWWP1 domain with Kd value of 3.4μM and abrogates histone H3K36me2 binding to the PWWP1 domain in cells. |
| CSN27842 | 5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one | 292168-90-2 | IT-603 is a c-Rel inhibitor with IC50 value of 3μM. |
| CSN27837 | 3,6-Diamino-9-(2-(methoxycarbonyl)phenyl)xanthylium chloride | 62669-70-9 | |
| CSN27843 | 9-(2,4-Disulfophenyl)-2,3,6,7,12,13,16,17-octahydro-1H,5H,11H,15H-xantheno[2,3,4-ij:5,6,7-i'j']diquinolizin-18-ium inner salt | 60311-02-6 | Sulforhodamine 101, a fluorescent dye (Ex ~586nm, Em ~606nm), is a selective astrocyte marker. |
| CSN27847 | 4-((4-(2,4-Dichlorophenyl)-3-ethylthiazol-2(3H)-ylidene)amino)benzenesulfonamide | 2561476-24-0 | EMAC10101d is a potent and selective Carbonic Anhydrase II inhibitor. |
| CSN27848 | 5-(5-(6-(4-Acetylpiperazin-1-yl)-3-nitropyridin-2-yl)-2-fluorobenzylidene)thiazolidine-2,4-dione | 853953-65-8 | GW604714X is a highly specific MPC (mitochondrial pyruvate carrier) inhibitor with Ki value<0.1nM. |
| CSN27850 | N-(Benzo[d][1,3]dioxol-5-yl(5-chloro-8-hydroxyquinolin-7-yl)methyl)butyramide | 423145-35-1 | YUM70 is a GRP78 inhibitor with IC50 value of 1.5μM and resulted in ER stress-mediated apoptosis. It inhibited pancreatic cancer cell growth in vit |
| CSN27849 | (S)-N-(3-(1-((6-(3,4-Dimethoxyphenyl)pyrazin-2-yl)amino)ethyl)phenyl)-5-methylnicotinamide | 1619931-27-9 | Seralutinib is a potent and novel inhaled PDGFR inhibitor, used in the study for pulmonary arterial hypertension. |
| CSN27868 | (S)-N-(4-(tert-Butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide | 1417700-12-9 | 16-(S)-ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with good enzyme and antiviral inhibitory activity. |
| CSN27872 | rel-N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)-5-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | 2193462-87-0 | Melatonin Biotin is compound conjuncted melatonin with biotin. |
| CSN27873 | N-(1-(Dimethylamino)propan-2-yl)-2-(pyridin-4-yl)-1H-benzo[d]imidazole-7-carboxamide | 2438721-44-7 | ChX710 can boost cellular response to cytosolic DNA via STING. It efficiently primed cellular response to transfected plasmid DNA as assessed by poten |
| CSN28337 | 5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 1445-07-4 | Pseudouridine is a modified nucleoside. |
| CSN27986 | (R)-2,3-Bis(oleoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate | 4235-95-4 | 1,2-DOPC is a phospholipid utilized for liposome production. |
| CSN28422 | 2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one | 724711-21-1 | MK2 Inhibitor III is a potent and selective MK-2 inhibitor with IC50 value of 8.5nM. |
| CSN28421 | 2-(((5-Bromothiophen-2-yl)methylene)amino)benzamide | 304456-62-0 | MDK6620 is a potent and selective IMP1 inhibitor by inhibiting IMP1 binding to c-Myc mRNA with IC50 value of 5μM. It downregulates several mRNA transc |
| CSN28430 | 3-((3-(N-Cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(3,5-difluorophenoxy)benzoic acid | 1445879-21-9 | GSK2837808A is a potent and selective LDHA and LDHB inhibitor with IC50 values of 2.6nM and 43nM for LDHA and LDHB, respectively. It reduces glucose u |
| CSN28431 | 3-(2-Chloro-6-methylphenyl)-7-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-1-(5-methoxypyridin-2-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one | 1936529-65-5 | YKL-05-099 is a selective SIK inhibitor with IC50 values of 10 nM, 40 nM and 30 nM for SIK1, SIK2 and SIK3, respectively. |
| CSN26245 | N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide | 850467-66-2 | TAO Kinase inhibitor 1 is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, |
| CSN28747 | ((4-Hydroxybutyl)azanediyl)bis(hexane-6,1-diyl) bis(2-hexyldecanoate) | 2036272-55-4 | ALC-0315, a cationic lipid, is a potent siRNA delivery vehicle. It can be used to form LNPs. |
| CSN28763 | 2-(3-(3-((5-Ethyl-4'-fluoro-2-hydroxy-[1,1'-biphenyl]-4-yl)oxy)propoxy)-2-propylphenoxy)benzoic acid | 161172-51-6 | LY293111 is a potent LTB4 receptor antagonist with IC50 values of 17.6nM and 6.3nM for inhibition of the specific binding of radiolabeled-LTB4 to isol |
| CSN28765 | N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide | 306959-01-3 | MYLS22 is a first-in-class small molecule-specific OPA1 inhibitor which inhibits tumor angiogenesis, impacts tumor growth and metastatization dependen |
| CSN28769 | tert-Butyl ((S)-5-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-phenylpropanamido)-6-((4-(hydroxymethyl)phenyl)amino)-6-oxohexyl)carbamate | 756487-18-0 | TKN8718 is a hydrolyzable ADC linker. |
| CSN28768 | (9H-Fluoren-9-yl)methyl ((S)-1-(((S)-6-((tert-butoxycarbonyl)amino)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxohexan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate | 206133-42-8 | Fmoc-Phe-Lys(Boc)-PAB is a hydrolyzable ADC linker. |
| CSN28771 | (2R,3R,4S,5R)-2-(7-Amino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | 10299-44-2 | 8-Azaadenosine is an ADAR1inhibitor. |
| CSN28783 | 1,1'-(2,2-Dimethylpropane-1,3-diyl)bis(3,4-dichloro-1H-pyrrole-2,5-dione) | 203115-63-3 | NSC 617145 is a WRN helicase inhibitor with IC50 value of 250nM. |
| CSN28782 | (R)-N-(5-(3-Hydroxypyrrolidin-1-yl)-2-morpholinooxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide | 1801344-14-8 | CA-4948 is a selective and orally bioavailable IRAK4 Inhibitor. It exhibited desirable ADME and PK profiles including good oral bioavailability in mic |
| CSN28781 | N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine | 1578245-44-9 | BOS172722 is clinical candidate Mps1 inhibitor with IC50 value of 11nM. |
| CSN28785 | (1-(6-((5-(4-(Dimethylamino)piperidin-1-yl)pyridin-2-yl)amino)-2-((4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-4-yl)piperidin-4-yl)methanol | 2225887-26-1 | EGFR-IN-5 is an inhibitor of EGFR with IC50 values of 10.4 nM, 1.1 nM, 34 nM and 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797 |
| CSN29557 | 5-Amino-2-(2,6-diisopropylphenyl)isoindoline-1,3-dione | 100823-03-8 | TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. |
| CSN29564 | N-(3-(4-Fluorophenylsulfonamido)-4-methoxyphenyl)-[1,1'-biphenyl]-4-carboxamide | 727699-84-5 | DUN99845 was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disea |
| CSN29561 | 7-(4-(tert-Butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione | 333415-38-6 | VU0071063 can activate native Kir6.2/SUR1 channels, thereby inhibiting glucose-stimulated calcium entry in isolated mouse pancreatic β cells. |
| CSN29565 | N-(3-(4-Fluorophenylsulfonamido)-4-hydroxyphenyl)-[1,1'-biphenyl]-4-carboxamide | 2249435-90-1 | SN-011 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-mediated disease. SN-011 is a |
