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货号 | 产品名称 | CAS号 | 简介 |
---|---|---|---|
CSN25551 | ((2R,3S,4R,5R)-3,4-Dihydroxy-5-(4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate | 2635324-86-4 | EIDD-2801 is an orally bioavailable prodrug of EIDD-1931, which has a broad-spectrum antiviral activity against 39 multiple coronaviruses, including S |
CSN25566 | (2S,4R)-1-(2-(3-Acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide | 1903768-17-1 | Danicopan is selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. It |
CSN25632 | 3-([(3,4-DIchlorophenyl)amino]carbonyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid | 199735-88-1 | CADD522 is a small molecule that inhibits the DNA binding of RUNX2. It negatively regulated transcription of RUNX2 target genes such as matrix metallo |
CSN25635 | 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide | 350997-39-6 | O8 OGG1 Inhibitor is an inhibitor of OGG1 with IC50 value of 0.35μM in fluorescence-based OGG1 assays. It can inhibit Schiff base formation during OGG |
CSN25655 | Ethyl 5-(7-(chlorodifluoromethyl)-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carboxamido)-1-phenyl-1H-pyrazole-4-carboxylate | 944547-46-0 | Mycro3 is a small-molecule inhibitor of Myc-Max dimerization. The average residual tumor of Pdx1-cre/KRAS* mice after Mycro3 treatment (100mg/kg, oral |
CSN25872 | N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide | 838810-96-1 | MAC-545496 is a nanomolar inhibitor of GraR. It reverses β-lactam resistance in the community-acquired MRSA USA300 strain. |
CSN25874 | 6-Methyl-3-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-5H-[1,2,4]triazino[5,6-b]indole | 327031-55-0 | VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation, potentiated the effect of radiation in tumor spheroids in a synergistic manne |
CSN26106 | N-(3-Bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine | 2305154-31-6 | JCN037 is a potent EGFR inhibitor with IC50 values of 2.49 nM, 3.95 nM and 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively. It displayed potent a |
CSN26157 | (R)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,9-tetrahydro-6H-purin-6-one | 618913-30-7 | AZD5904 is a potent and irreversible MPO inhibitor with IC50 value of 140nM. Continuous subcutaneous AZD5904 infusion during the 2 week selectively bl |
CSN26164 | (3E,5E)-3,5-Bis(4-nitrobenzylidene)piperidin-4-one | 919091-63-7 | RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 2 |
CSN27187 | 4-(((5'-chloro-2'-(((1R,4r)-4-(((R)-1-methoxypropan-2-yl)amino)cyclohexyl)amino)-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile | 1263373-43-8 | NVP-2 is a potent and selective ATP-competitive CDK9 inhibitor with IC50 value of 0.5nM. |
CSN27185 | 5-Benzyl-2-hydroxy-3-nitrobenzaldehyde | 328565-16-8 | Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. Col003 is the cleavage product of AK778.It compe |
CSN27196 | (2-Amino-4-(trifluoromethoxy)phenyl)(4-(7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl)piperidin-1-yl)methanone | 2307249-33-6 | BAY-885 is a highly potent and selective ERK5 inhibitor with IC50 value of 35nM. |
CSN27227 | (E)-N-(4-((E)-3,5-Dimethoxystyryl)phenyl)-3-(3,4,5-trimethoxyphenyl)acrylamide | 2059952-75-7 | STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 |
CSN27236 | (4S,7S,10S,13S)-13-(2-Chloroacetyl)-4-(4-hydroxybenzyl)-7-isopropyl-10-methyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid | 178603-78-6 | Ac-YVAD-CMK is a tetrapeptide ICE inhibitor. |
CSN27229 | (S)-5-((1-(3-Oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one | 2381037-82-5 | RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN-2397 selectively binds to PARP7 (Kd=0.001 |
CSN27231 | 4-(3-Benzyl-4-{[5-(2-fluorophenyl)furan-2-yl]methylidene}-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid | 916232-21-8 | GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activati |
CSN27232 | (R)-4-(2-((5-Fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine | 1253573-53-3 | AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks, with Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively. AM |
CSN27247 | N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide | 372196-67-3 | PIK-75 is a selective p110α inhibitor with IC50 of 5.8 nM with 200-fold more potently than p110β, and also potently inhibits DNA-PK with IC50 of 2 nM. |
CSN27252 | 3,4-Dihydroxy-N'-(2-hydroxybenzylidene)benzohydrazide | 304481-60-5 | KM91104 is a specific v-ATPase inhibitor. It specifically targets the interaction between v-ATPase subunit a3 and subunit B2. |
CSN27270 | Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate | 2375421-09-1 | SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Ant |
CSN27278 | 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide | 1375466-18-4 | ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM. |
CSN27283 | 6-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide | 1655504-04-3 | Orelabrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. |
CSN27291 | 5-((2,5-Dichloropyrimidin-4-yl)amino)-3-(3-hydroxy-3-methylbutyl)-1-methyl-1H-benzo[d]imidazol-2(3H)-one | 2253878-09-8 | BCL6-IN-5 is a potent BCL6 inhibitor exacted from patent WO2018215801A1 with pIC50 of 5.82. |
CSN27285 | 4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine | 1841460-82-9 | TH1020 is Toll-like receptor (TLR) 5/Flagellin complex antagonist with IC50 of 0.85 μM. TH1020 competes with flagellin for TLR5 binding to inhibit the |
CSN27287 | (S)-N2-(Benzo[d]oxazol-6-yl)-N4-(1-cyclohexylethyl)-N6-ethyl-N6-(2-(ethylamino)ethyl)-1,3,5-triazine-2,4,6-triamine | 1456891-34-1 | LS-102 is a selective inhibitor of E3 ubiquitin ligase synoviolin (Syvn1). LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. |
CSN27297 | (2S)-6-Amino-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-2-[(2R)-3-{[2,3-bis(hexadecanoyloxy)propyl]sulfanyl}-2-hexadecanamidopropanamido]-3-hydroxypropanamido]hexanamido]hexanamido]hexanamido]hexanoic acid | 112208-00-1 | Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2 . |
CSN27303 | 1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine | 132834-56-1 | Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-H |
CSN27306 | 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid | 166108-71-0 | Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
CSN27302 | 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one | 129722-25-4 | Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D |
CSN27575 | (2R,3R)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)chroman-4-one | 54081-48-0 | Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase |
CSN27383 | 3-Ethyl 5-methyl (S)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate | 103129-82-4 | Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of |
CSN27585 | N-Methyl-9H-pyrido[3,4-b]indole-3-carboxamide | 78538-74-6 | FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM |
CSN27586 | 1-(4-Bromobenzyl)indole-2,3-dione | 79183-37-2 | VU0119498 is a M1 muscarinic receptor agonist with EC50 of 3.1 μM, and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective a |
CSN27595 | 7-Chloro-1-(4-(trifluoromethyl)benzyl)indoline-2,3-dione | 85511-68-8 | VU0238441 is a potent agonist of muscarinic acetylcholine receptor M5 with EC50 of 2.1 μM. |
CSN27598 | N-(4-Chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide | 732973-87-4 | GOT1 inhibitor 2c is a GOT1 inhibitor with IC50 value of 8.2μM. |
CSN27656 | 2-(4-Chlorophenyl)-6-nitro-1H-1,3-benzodiazole | 1571-87-5 | GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity. |
CSN27669 | (4-((2-(2,5-Dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone | 1309241-34-6 | GRP-60367 is a potent and selective rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. |
CSN27673 | N-(1-(2,4-Bis(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-5-(furan-2-yl)isoxazole-3-carboxamide | 2323027-38-7 | Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress with IC50 of 0.59 μM. |
CSN27658 | (E)-2-([1,1'-Biphenyl]-4-ylamino)-N-hydroxy-2-oxoacetimidoyl cyanide | 1263303-95-2 | DHODH-IN-11, a leflunomide derivative, is a weak inhibitor of dihydroorotate dehydrogenase (DHODH) with pKa of 5.03. |
CSN27661 | 9-Isopropyl-N2,N6-bis(4-methoxybenzyl)-9H-purine-2,6-diamine | 267402-71-1 | Myoseverin is a microtuble-binding molecule and reversible inhibitor of tubulin polymerization. It binds to tublin leading to multinucleated myotubes |
CSN27671 | (R)-2-(6-(5-Chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide | 2095719-92-7 | ASTX-029 is selective inhibitor of the extracellular signal-regulated kinases 1 and 2 (ERK 1/2) with potential antineoplastic activity. |
CSN27659 | Methyl 3-(4-methylbenzenesulfonamido)benzoate | 173436-66-3 | MSAB is a selective inhibitor of Wnt/β-catenin signaling. It binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-cateni |
CSN52420 | N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine | 300842-64-2 | |
CSN27710 | 3-Mercaptopicolinic acid hydrochloride | 320386-54-7 | SKF-34288 HCl is a PEPCK inhibitor which could inhibit glucose synthesis through inhibition of PEPCK in the gluconeogenesis pathway. |
CSN27724 | 3-Fluoro-N'-((5-nitrothiophen-2-yl)methylene)benzohydrazide | 394694-98-5 | MitoBloCK-10 is the first small molecule modulator to attenuate PAM (protein-associated motor) complex activity. It binds to a specific pocket in the |
CSN27725 | 1,3-Bis(3,5-dichlorophenyl)urea | 73439-19-7 | COH-SR4 is an AMPK activator with anticancer properties. It significantly inhibited adipocyte differentiation in a dose-dependent manner in 3T3-L1 cel |
CSN27766 | 5-(Bis(2-hydroxybenzyl)amino)-2-hydroxybenzoic acid | 125697-91-8 | Lavendustin B is a competitive Glut1 inhibitor with Ki value of 15µM. |
CSN27767 | (E)-2-(3,4-Dihydroxystyryl)-3-(2-methoxyphenyl)quinazolin-4(3H)-one | 2041072-41-5 | ICCB280 is a potent inducer of C/EBPα and myeloid differentiation. |