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| 货号 | 产品名称 | CAS号 | 简介 |
|---|---|---|---|
| CSN24749 | 1-((5-Bromothiophen-2-yl)sulfonyl)-1H-pyrazole | 902688-24-8 | Qstatin is a potent and selective inhibitor of Vibrio quorum sensing (QS). SmcR is the LuxR homologue in V. vulnificus. |
| CSN24753 | 3-(2-Amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile | 2239273-34-6 | AB928 is a dual A2aR/A2bR antagonist that inhibits A2aR and A2bR with an equilibrium binding constant of 1.4 and 2 nM, respectively. |
| CSN24754 | N-(4-Chlorophenyl)-3-((4-chlorophenyl)amino)-2-(3-methylisoxazol-5-yl)acrylamide | 917837-54-8 | CCMI is a positive allosteric modulator of α7 nAChRs. |
| CSN24752 | 4-Amino-8-(2,5-dimethoxyphenyl)-N-propylcinnoline-3-carboxamide | 942436-93-3 | |
| CSN24769 | (3-Chloro-4-fluorophenyl)(4-fluoro-4-((((5-methylpyrimidin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanone | 635323-95-4 | F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist with Ki value of 3.4nM. |
| CSN24767 | (E)-3-((1H-Indol-3-yl)methylene)-5-((E)-3,4-dimethoxybenzylidene)-1-methylpiperidin-4-one | 1370032-19-1 | CA-5f is identified as a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. It exhibted potential clin |
| CSN24771 | 2-Hydroxy-N,N,N-trimethylethan-1-aminium (Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoate | 2055362-74-6 | ADH-503 is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression. |
| CSN24778 | tert-Butyl 4-(4-(2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamido)benzyl)piperazine-1-carboxylate | 1311174-68-1 | PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial m |
| CSN24774 | 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide | 1870916-87-2 | Mc-Val-Ala-PAB is a useful ADC linker conjugating for targeting drug delivery. |
| CSN24780 | (1E,4E)-1,5-Bis(2-hydroxyphenyl)penta-1,4-dien-3-one | 131359-24-5 | 2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10. |
| CSN24773 | (9H-Fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate | 1394238-91-5 | Fmoc-Val-Ala-PAB is a useful ADC linker conjugating for targeting drug delivery. |
| CSN24803 | (R)-1-(3-(3-Amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylic acid | 2041073-22-5 | GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively |
| CSN24783 | rel-4-(((1R,4R)-4-hydroxycyclohexyl)amino)-4'-isopropyl-[1,1'-biphenyl]-3-carboxamide | 2234897-35-7 | Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1]. |
| CSN24782 | Methyl 4-((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)carbamoyl)benzoate | 947620-48-6 | Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM. |
| CSN24804 | (E)-2-Benzylidene-5-bromo-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one | 1245792-67-9 | BCI-215 is a hyperactivator of fibroblast growth factor signaling that is devoid of developmental toxicity and restores defective MAPK activity caused |
| CSN24788 | 4-Chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide | 1261289-04-6 | O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exh |
| CSN24797 | N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)acrylamide methanesulfonate | 2130958-55-1 | AST2818 mesylate is an EGFR inhibitor. |
| CSN24794 | (S)-N-(4-Fluoro-3-methylphenyl)-3-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzamide | 1572510-42-9 | JNJ-632 is a hepatitis B virus (HBV) capsid assembly modulator (CAM). |
| CSN24801 | Phenyl 2-(benzyloxy)-3-(dibenzylamino)-5-fluoro-6-methylbenzoate | 1253799-29-9 | TP353 is a CDK7 inhibitor. |
| CSN24802 | 1-(3-Chlorophenyl)-3-(5-(2-((7-(3-(dimethylamino)propoxy)quinazolin-4-yl)amino)ethyl)thiazol-2-yl)urea | 2443767-35-7 | DBPR114 is a potent multi-kinase inhibitor with potent activities against more than 57 oncogenic kinases, including Aurora-A, FLT3, CSF1R, MET, etc. D |
| CSN25213 | 2-((S)-1-Acryloyl-4-(7-(8-methylnaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile | 2206736-04-9 | MRTX1257 is a selective, covalent K-Ras G12C inhibitor with oral activity in animal models of cancer. |
| CSN25222 | 4-(2-(4-Aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-2-fluorobenzonitrile benzenesulfonate | 2097523-60-7 | CC-90011 is a potent and orally active LSD1 inhibitor. It is in phase I clinical study of CC-90011 in patients (pts) with advanced unresectable solid |
| CSN25216 | 1-(3-Fluorophenyl)-5-methylpyridin-2(1H)-one | 848353-85-5 | Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and ECM deposition via the PI3K/Akt signa |
| CSN25223 | (S)-2-((4-(6-((4-Cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylic acid | 2230198-02-2 | PF-06882961 is a potent and orally bioavailable GLP-1R agonist. |
| CSN25218 | 2-(4-Oxo-3-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid | 2170729-29-8 | AT-007 is a central nervous system (CNS) penetrant Aldose Reductase inhibitor (ARI) in Phase 1/2 development for treatment of Galactosemia. |
| CSN25217 | 4-(4-Chloro-2-fluorophenyl)-2-(2-chloropyridin-4-yl)-N-(6-fluoro-1H-indazol-5-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide | 874119-56-9 | GSK-25 is a ROCK1 inhibitor with IC50 value of 6nM. It showed oral bioavailability (49% in rat and 19% in monkey), good half-life (1.8 h in rat and 2. |
| CSN25228 | (S)-2-(Dimethylcarbamothioyl)-N-(2-methyl-4-(1-methyl-1,4,5,10-tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine-5-carbonyl)benzyl)pyrrolidine-1-carboxamide 2,2,2-trifluoroacetate | 2245072-21-1 | LIT-001 is the first nonpeptide oxytocin receptor agonist. |
| CSN25229 | m-Tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate | 882366-16-7 | SBI-115 is a GPBAR1 (TGR5) antagonist. |
| CSN25238 | 4-(Pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline | 358721-70-7 | UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone |
| CSN25239 | (S)-4-((S)-1-((S)-1-((S)-2-((3S,6S,9S,12R,18S,21S,24S,27S,30S,35AS)-18-((S)-2-((S)-1-((S)-2-Acetamido-3-methylbutanoyl)pyrrolidine-2-carboxamido)-3-(3-chlorophenyl)propanamido)-27-(4-aminobutyl)-9-benzyl-30-butyl-24-(3-guanidinopropyl)-6-(hydroxymethyl)-21-isobutyl-3-methyl-1,4,7,10,19,22,25,28,31-nonaoxodotriacontahydro-1H-pyrrolo[2,1-p][1,2,5,8,11,14,17,20,23,26,29]dithianonaazacyclotritriacontine-12-carboxamido)-6-aminohexanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamido)-5-amino-5-oxopentanoic acid 2,2,2-trifluoroacetic acid (1:x) | 1659305-79-9 | YAP-TEAD Inhibitor 1 is an inhibitor of this YAP-TEAD protein-protein interaction which has potential usage in treatment of YAP-involved cancers with |
| CSN25240 | (2S)-5-(2-Chloroethanimidamido)-2-(phenylformamido)pentanamide trifluoroacetic acid salt | 1043444-18-3 | Cl-amidine is a peptidylarginine deminase (PAD) inhibitor, with an IC50 5.9±0.3 μM for PAD4. |
| CSN25244 | N-(2-Aminoethyl)-2-(4-(2-(4-((9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)phenyl)acetamido)phenyl)acetamide | 96760-69-9 | Adenosine amine congener hydrate is a potent aqueous-soluble A1 adenosine receptor agonist with Ki value of 0.85nM for binding against [3H]N6-cyclohex |
| CSN25246 | 5-Chloro-2-((4-fluorobenzyl)sulfonyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)pyrimidine-4-carboxamide | 874146-69-7 | PK11007 is mild thiol alkylator with anticancer activity in several cell lines, especially those with mutationally compromised p53. |
| CSN25248 | 2-Methylpropan-2-amine (E)-3-(1-(5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)isoxazole-4-carbonyl)-3-methyl-1H-indol-4-yl)acrylate | 1898207-64-1 | DS-1001b is a novel selective mutant IDH1 inhibitor with antitumor activity. |
| CSN25251 | N-(4-Chlorophenyl)-5,5-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide | 1922098-69-8 | CCG-222740 is a Rho/MRTF pathway inhibitor. It decreases the activation of stellate cells in vitro and in vivo, by reducing the levels o |
| CSN25255 | (3S,6R,9S,12R,15S,18R,21S,24R)-3,9,15,21-tetraisobutyl-4,6,10,16,18,22-hexamethyl-12,24-bis(4-morpholinobenzyl)-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclotetracosan-2,5,8,11,14,17,20,23-octaone | 155030-63-0 | Emodepside is an antiparasitic that is effective against a number of gastrointestinal nematodes, used in cat. |
| CSN25271 | (S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-3-(1-(2-methylbutanoyl)piperidin-4-yl)urea | 1809885-32-2 | EC5026 is a first-in-class, small molecule that potently inhibits soluble Epoxide Hydrolase (sEH), a key regulatory enzyme involved in the metabolism |
| CSN25277 | 2-((4-Bromobenzyl)thio)benzo[d]oxazole | 100874-08-6 | sb4 is a potent BMP4 agonist. |
| CSN25276 | 2-Allyl-6-(((1-propyl-1H-benzo[d]imidazol-2-yl)amino)methyl)phenol | 692269-09-3 | CM10 is an ALDH1A inhibitor that depletes CD133+ cancer stem cells. |
| CSN25279 | 2-((5-Chloroquinolin-8-yl)oxy)-N,N-diethylethanamine dihydrochloride | 861038-72-4 | A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. A2764 can inhibit TRESK in native cells, leading to c |
| CSN25282 | (E)-2-(2,3-Dichlorobenzylidene)hydrazine-1-carboximidamide | 2022961-17-5 | Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease. In cells, Raphi |
| CSN25292 | Diethyl 4-((4-bromo-2-cyanophenyl)carbamoyl)benzylphosphonate | 133208-93-2 | Ibrolipim is a Lipoprotein lipase activator. |
| CSN25290 | 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)urea | 2165324-62-7 | PK150 is an analogue of Sorafenib, with oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrat |
| CSN25284 | 1-(3-(1H-Imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea | 790663-33-1 | PBD-150 is a potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM. |
| CSN25289 | (4-Benzhydrylpiperazin-1-yl)(1,5-dimethyl-1H-pyrazol-3-yl)methanone | 958323-31-4 | TLX agonist 1 (ccrp2) is an orphan nuclear receptor tailless (TLX, NR2E1) modulator with EC50 of 1μM and Kd of 650 nM. |
| CSN25293 | 2-((4-(Pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole trihydrochloride | 587870-77-7 | ABT-724 3HCl is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, |
| CSN25299 | 4-Fluoro-3-(((5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)methyl)amino)-N-(3-(trifluoromethoxy)phenyl)benzamide | 2442597-56-8 | VU6015929 is a potent, selective and orally active dual discoidin domain receptor 1/2 (DDR1/2) inhibitor with IC50 values of 4.67 nM and 7.39 nM, resp |
| CSN25306 | 2-(3-Benzoylthioureido)-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid | 314042-01-8 | CID-1067700 is a potent and competitive inhibitor of Ras-related GTPases inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki |
| CSN25303 | 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine hydrochloride | 2453324-32-6 | CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA k |
| CSN25308 | L-Arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine | 60482-95-3 | Neurotensin Fragment 8-13 is the smallest active fragment of neurotensin which is a potent cellular mitogen for various colorectal and pancreatic canc |
