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AChR
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN24514 | α-Conotoxin PnIA | 705300-84-1 | α-Conotoxin PnIA is a selective antagonist of α3β2 nAChR receptors (IC50 = 9.56 nM) and α7 receptors (IC50 = 252 nM). |
CSN24532 | α-Conotoxin PIA | 669050-68-4 | α-Conotoxin PIA is a selective antagonist of α6-containing nAChRs with IC50 values of 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively. |
CSN24553 | α-Conotoxin M II | 175735-93-0 | α-Conotoxin MII is a potent and selective α3β2 and β3 nAChR antagonist. |
CSN24535 | α-Conotoxin Au IB | 216299-21-7 | α-Conotoxin AuIB is a selective antagonist of α3β4 nicotinic acetylcholine receptors. |
CSN24539 | Zamifenacin fumarate | 127308-98-9 | Zamifenacin fumarate is a selective M3 muscarinic receptor antagonist with pKi value of 8.52. |
CSN51368 | VU0152099 | 612514-42-8 | VU0152100 is a potent and selective allosteric potentiator of M4 mAChR. |
CSN24545 | VU 10010 | 633283-39-3 | VU 10010 is a selective allosteric potentiator of M4 acetylcholine receptor. |
CSN24529 | VU 0238429 | 1160247-92-6 | VU 0238429 is a selective positive allosteric modulator of M5 receptors with EC50 values of 1.16, >30 and >30 μM at M5, M1 and M3 receptors respectively. |
CSN21894 | Vinconate | 70704-03-9 | Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor. |
CSN21914 | Tiotropium Bromide H2O | 411207-31-3 | Tiotropium Bromide is an considsered a long acting muscarinic receptor antagonist (LAMA) and is used clinically as an inhaled bronchodilator for COPD and asthma. |
CSN21862 | SA-504 | 35035-05-3 | Timepidium bromide is an anticholinergic agent. |
CSN21851 | Tematropium | 113932-41-5 | Tematropium (CDDD3602) is a soft anticholinergics. |
CSN24523 | Telenzepine 2HCl | 147416-96-4 | Telenzepine 2HCl is a selective high affinity muscarinic M1 receptor antagonist with Ki of 0.94 nM. |
CSN26510 | Tebanicline dihydrochloride | 209326-19-2 | Tebanicline dihydrochloride (Ebanicline dihydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM[1]. |
CSN25667 | TC 2559 difumarate | 212332-35-9 | TC 2559 difumarate is a selective partial agonist of α4β2 receptors. The EC50 values are 0.18, 12.5, 14.0μM for α4β2, α4β4, α2β4 receptor subtypes respectively. |
CSN24541 | Perlapine | 1977-11-3 | Perlapine is a potent muscarinic DREADD agonist. |
CSN24547 | Oxotremorine sesquifumarate | 17360-35-9 | Oxotremorine sesquifumarate is a muscarinic agonist. |
CSN24548 | Oxotremorine M | 63939-65-1 | Oxotremorine M is a muscarinic agonist. |
CSN24538 | McN-A 343 | 55-45-8 | McN-A 343 is a selective muscarinic M1 receptor agonist. |
CSN19397 | Galanthamine | 357-70-0 | Galanthamine is a long-acting, centrally active acetylcholinesterase (AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. |
CSN19398 | Galanthamine Hydrobromide | 1953-04-4 | Galanthamine hydrobromide is a natural occuring AchE inhibitor with IC50 value of 410nM and allosteric potentiator at neuronal nAchRs, used for the treatment of cognitive decline in mild to moderate Alzheimer's disease and various other memory impairments. |
CSN26519 | Fesoterodine | 286930-02-7 | Fesoterodine is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the overactive bladder (OAB)[1][2]. |
CSN22004 | ENS-163 phosphate | 117707-51-4 | ENS-163 phosphate is a selective muscarinic M1 receptor agonist. |
CSN21625 | Elucaine | 25314-87-8 | Elucaine is an antagonist of muscarinic acetylcholine receptor with anti-ulcerative activity. |
CSN24537 | DMP 543 | 160588-45-4 | DMP 543 is a sitmulator of acetylcholine release. It can enhance K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM) and increase release of dopamine and glutamate (EC50 = 0.25 and 0.22 μM, respectively). |
CSN24518 | Dihydro-β-erythroidine hydrobromide | 29734-68-7 | Dihydro-β-erythroidine hydrobromide is a nicotinic acetylcholine receptor antagonist of neuronal α4 receptor subunit, the IC50 values against α4β4 and α4β2 receptors are 0.19 and 0.37 μM, espectively. |
CSN24540 | DAU 5884 HCl | 131780-48-8 | DAU 5884 HCl is a selective muscarinic M3 receptor antagonist. |
CSN21591 | Darenzepine | 84629-61-8 | Darenzepine is an inhibitor of muscarinic receptor. |
CSN24531 | Chlorisondamine diiodide | 96750-66-2 | Chlorisondamine diiodide is an exceptionally long lasting nicotinic antagonist with IC50 of ~ 1.6 mM. |
CSN24551 | Benzoquinonium dibromide | 311-09-1 | Benzoquinonium dibromide is a nicotinic antagonist. |
CSN24542 | Arecaidine propargyl ester tosylate | 147202-94-6 | Arecaidine propargyl ester tosylate is a potent muscarinic receptor agonist. |
CSN24556 | AR-R 17779 hydrochloride | 178419-42-6 | AR-R 17779 hydrochloride is a selective alpha7 nicotinic agonist with Ki value of 190 nM for rat. |
CSN29468 | AQW-051 | 669770-29-0 | AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56. |
CSN24525 | AQ-RA 741 | 123548-16-3 | AQ-RA 741 is a high affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2, M1 and M3 receptors, respectively). |
CSN22098 | Ambutonium Bromide | 115-51-5 | Ambutonium bromide is an acetylcholine antagonist. |
CSN24526 | AF-DX 384 | 118290-26-9 | AF-DX 384 is a potent M2/M4 selective antagonist with pKi values of 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively. |
CSN24524 | AF-DX 116 | 102394-31-0 | AF-DX 116 is a selective M2 muscarinic receptor antagonist with Ki values of 64, 417, 786, 211 and 5130 nM for human recombinant M2, M1, M3, M4 and M5 muscarinic receptors, respectively. |
CSN24517 | ABT 089 dihydrochloride | 161416-61-1 | ABT 089 dihydrochloride is the high affinity and selective partial agonist of α4β2 with Ki of 16 nM. |
CSN24549 | 5-Methylfurmethiodide | 1197-60-0 | 5-Methylfurmethiodide is a potent muscarinic agonist. |
CSN24543 | 4-DAMP | 1952-15-4 | 4-DAMP is a muscarinic M3 antagonist. |
CSN24533 | 4-Acetyl-1,1-dimethylpiperazinium iodide | 75667-84-4 | 4-Acetyl-1,1-dimethylpiperazinium iodide is a nAChR agonist with Ki of 29.9 nM at α4β2. |
CSN24521 | 3-Bromocytisine | 207390-14-5 | 3-Bromocytisine is an agonist of α4β4, α4β2 and α7 nACh receptors with IC50s of 0.28, 0.30 and 31.6 nM respectively. |
CSN24552 | 1-Acetyl-4-methylpiperazine hydrochloride | 144205-68-5 | 1-Acetyl-4-methylpiperazine hydrochloride is a nAChR agonist. |
CSN24530 | (¡À)-Anatoxin A fumarat | 1219922-30-1 | (¡À)-Anatoxin A fumarat is a potent nicotinic agonist with Ki values of 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively. |
CSN24562 | (S)-(+)-Dimethindene maleate | 136152-65-3 | (S)-(+)-Dimethindene maleate is a subtype-selective M2 muscarinic receptor antagonist with pKi of 7.78 and is also a H1 histamine receptor antagonist with pKi of 7.48. |