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AChR

AChR

货号 产品名 CAS号 信息
CSN27595 VU0238441   85511-68-8 VU0238441 is a potent agonist of muscarinic acetylcholine receptor M5 with EC50 of 2.1 μM.
CSN27586 VU0119498   79183-37-2 VU0119498 is a M1 muscarinic receptor agonist with EC50 of 3.1 μM, and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
CSN23552 VU 0365114 1208222-39-2 VU 0365114 is a allosteric modulator of M5 with EC50 of 2.7 μM.
CSN21941 Tacrine HCl H2O 206658-92-6 Tacirne is an active cholinesterase inhibitor that blocks the degradation of cholinergic nerves in the cerebral cortex and hippocampus to increase cholinergic transmission. Tacrine induces hepatic damages in vitro. It can also induce oxidative stress and mitochondrial dysfunction. Tacrine treatment in HepG2 cells markedly inhibits the phosphorylation of GSK3β.
CSN21835 Solifenacin 242478-37-1 Solifenacin is a competitive antagonist of muscarinic receptors that potently blocks signaling through M1, M2, and M3 with Kis of 25, 125, and 10 nM, respectively.
CSN23842 Scopolamine N-Oxide HydrobroMide Monohydrate N/A Scopolamine N-oxide hydrobromide is an antagonist of the muscarinic acetylcholine.
CSN24865 Raceanisodamine 17659-49-3 Raceanisodamine is the active ingredient of Chinese herbal extracts that has vasoactive activity used to treat acute disseminated intravascular coagulation in patients in bacteremic shock.
CSN17113 Promethazine HCl 58-33-3 Promethazine HCl is the effective antagonist of the H1 receptor and moderate antagonist of mACh receptor.
CSN25236 Pirmenol 68252-19-7 Pirmenol inhibited the muscarinic acetylcholine receptor-operated K+ current (I[K.ACh]) in atrial cells and on experimental atrial fibrillation in isolated guinea-pig hearts.
CSN19465 Pirmenol HCl 61477-94-9 Pirmenol HCl inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM.
CSN24546 N,N,N-Trimethyl-4-(2-oxopyrrolidin-1-yl)but-2-yn-1-aminium iodide 3854-04-4 Oxotremorine M iodide is a potent and selective muscarinic acetylcholine receptor (mAChR) agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms[1].
CSN19962 N-Methylcytisine 486-86-2 N-Methylcytisine's nicotinic receptors have high affinity (KD = 50 nM)to nAChR from squid optical ganglia.
CSN21136 Methylbenactyzium Bromide 3166-62-9 Methylbenactyzium Bromide is a mAchR antagonist, used as a spasmolytic for the treatment of gastrointestinal ulcer and gastrointestinal spasms.
CSN24142 Mecamylamine HCl 826-39-1 Mecamylamine HCl is a non-competitive nicotinic acetylcholine receptor antagonist with antidepressant-like effects in mice.
CSN24909 Sparteine 492-08-0 Inhibition of human CYP2D6 expressed in Escherichia coli JM109
CSN19397 Galanthamine 357-70-0 Galanthamine is a long-acting, centrally active acetylcholinesterase (AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors.
CSN19398 Galanthamine Hydrobromide 1953-04-4 Galanthamine hydrobromide is a natural occuring AchE inhibitor with IC50 value of 410nM and allosteric potentiator at neuronal nAchRs, used for the treatment of cognitive decline in mild to moderate Alzheimer's disease and various other memory impairments.
CSN20647 Epibatidine 148152-66-3 Epibatidine is a high affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively).
CSN23811 Dicyclomine HCl 67-92-5 Dicyclomine is an anticholinergic that blocks muscarinic receptors. Dicyclomine is used to treat intestinal hypermotility and the symptoms of irritable bowel syndrome (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.
CSN22786 Dianicline 292634-27-6 Dianicline is a selective α4β2 nAChR partial agonist with IC50 of 105 nM.
CSN25424 Cyclopentolate HCl 5870-29-1 Cyclopentolate (DL-Cyclopentolate) hydrochloride is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle). Cyclopentolate hydrochloride is an anti-muscarinic agent commonly used in the ophthalmologic practice.
CSN20356 BQCA 338747-41-4 BQCA is a highly selective allosteric potentiator of the M1 mAChR and reduces the concentration of ACh required to activate M1 up to 129-fold with an inflection point value of 845 nM.
CSN22357 Beperidium Iodide 86434-57-3 Beperidium iodide shows a competitive antagonistic effect against acetylcholine receptor with a pA2 of 7.93.
CSN20796 Benactyzine HCl 57-37-4 Benactyzine HCl is a centrally acting mAchR antagonist, used in the treatment of depression and in research to investigate the role of cholinergic systems on behavior.
CSN19803 AFDX384 118290-27-0 AFDX384 is a bioactive chemical interacting with muscarinic acetylcholine receptor.
CSN25275 (S)-PNU-282987 HCl 128311-08-0 (S)-PNU-282987 is the an absolute stereochemistry form of PNU-282987.
CSN24754 CCMI   917837-54-8
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