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AChR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN27595 | VU0238441 | 85511-68-8 | VU0238441 is a potent agonist of muscarinic acetylcholine receptor M5 with EC50 of 2.1 μM. |
| CSN27586 | VU0119498 | 79183-37-2 | VU0119498 is a M1 muscarinic receptor agonist with EC50 of 3.1 μM, and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent. |
| CSN23552 | VU 0365114 | 1208222-39-2 | VU 0365114 is a allosteric modulator of M5 with EC50 of 2.7 μM. |
| CSN21941 | Tacrine HCl H2O | 206658-92-6 | Tacirne is an active cholinesterase inhibitor that blocks the degradation of cholinergic nerves in the cerebral cortex and hippocampus to increase cholinergic transmission. Tacrine induces hepatic damages in vitro. It can also induce oxidative stress and mitochondrial dysfunction. Tacrine treatment in HepG2 cells markedly inhibits the phosphorylation of GSK3β. |
| CSN21835 | Solifenacin | 242478-37-1 | Solifenacin is a competitive antagonist of muscarinic receptors that potently blocks signaling through M1, M2, and M3 with Kis of 25, 125, and 10 nM, respectively. |
| CSN23842 | Scopolamine N-Oxide HydrobroMide Monohydrate | N/A | Scopolamine N-oxide hydrobromide is an antagonist of the muscarinic acetylcholine. |
| CSN25236 | Pirmenol | 68252-19-7 | Pirmenol inhibited the muscarinic acetylcholine receptor-operated K+ current (I[K.ACh]) in atrial cells and on experimental atrial fibrillation in isolated guinea-pig hearts. |
| CSN19465 | Pirmenol HCl | 61477-94-9 | Pirmenol HCl inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM. |
| CSN21136 | Methylbenactyzium Bromide | 3166-62-9 | Methylbenactyzium Bromide is a mAchR antagonist, used as a spasmolytic for the treatment of gastrointestinal ulcer and gastrointestinal spasms. |
| CSN24142 | Mecamylamine HCl | 826-39-1 | Mecamylamine HCl is a non-competitive nicotinic acetylcholine receptor antagonist with antidepressant-like effects in mice. |
| CSN19428 | Lobeline HCl | 134-63-4 | Lobeline HCl is a mixed agonist–antagonist of nAchR agonist and has multiple function such as VMAT2 ligand, inhibiting the reuptake of dopamine and serotonin, antagonist at μ-opioid receptors and P-glycoprotein inhibitor. |
| CSN19385 | Isoimperatorin | 482-45-1 | Isoimperatorin is a natural occuring acetylcholinesterase inhibitor with IC50 value of 74.6μM, extracted from Angelica dahurica and Angelica koreana. |
| CSN19398 | Galanthamine Hydrobromide | 1953-04-4 | Galanthamine hydrobromide is a natural occuring AchE inhibitor with IC50 value of 410nM and allosteric potentiator at neuronal nAchRs, used for the treatment of cognitive decline in mild to moderate Alzheimer's disease and various other memory impairments. |
| CSN23811 | Dicyclomine HCl | 67-92-5 | Dicyclomine is an anticholinergic that blocks muscarinic receptors. Dicyclomine is used to treat intestinal hypermotility and the symptoms of irritable bowel syndrome (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant. |
| CSN25424 | Cyclopentolate HCl | 5870-29-1 | Cyclopentolate (DL-Cyclopentolate) hydrochloride is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle). Cyclopentolate hydrochloride is an anti-muscarinic agent commonly used in the ophthalmologic practice. |
| CSN20356 | BQCA | 338747-41-4 | BQCA is a highly selective allosteric potentiator of the M1 mAChR and reduces the concentration of ACh required to activate M1 up to 129-fold with an inflection point value of 845 nM. |
| CSN22357 | Beperidium Iodide | 86434-57-3 | Beperidium iodide shows a competitive antagonistic effect against acetylcholine receptor with a pA2 of 7.93. |
| CSN20796 | Benactyzine HCl | 57-37-4 | Benactyzine HCl is a centrally acting mAchR antagonist, used in the treatment of depression and in research to investigate the role of cholinergic systems on behavior. |
| CSN19803 | AFDX384 | 118290-27-0 | AFDX384 is a bioactive chemical interacting with muscarinic acetylcholine receptor. |
| CSN25275 | (S)-PNU-282987 HCl | 128311-08-0 | (S)-PNU-282987 is the an absolute stereochemistry form of PNU-282987. |
| CSN24754 | CCMI | 917837-54-8 |