优势价格
快速发货
品质保证
技术支持
400-920-2911 sales@csnpharm.cn
AChR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN16954 | Xanomeline oxalate | 141064-23-5 | Xanomeline Oxalate is a selective M1 muscarinic receptor agonist. |
| CSN15876 | VU0357017 HCl | 1135242-13-5 | VU 0357017 HCl is a positive allosteric modulator of muscarinic M1 receptors with EC50 value of 198 nM. |
| CSN13865 | N-(3-Oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide | 1135243-19-4 | VU 0255035 is a highly selective and brain penetrant M1 antagonist with Ki value of 14.87 nM, targeting the M1 orthosteric site. |
| CSN16627 | VU0152100 | 409351-28-6 | VU 0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM. |
| CSN12643 | Vecuronium bromide | 50700-72-6 | Vecuronium bromide is a competitive AchR inhibitor and binds to cholinergic receptors at neuromuscular junctions, used as an aminosteroidal neuromuscular blocking agent. |
| CSN13851 | 1-(2-(Benzyloxy)ethyl)-4-(hydroxydiphenylmethyl)quinuclidin-1-ium bromide | 869113-09-7 | Umeclidinium bromide is a long-acting mAchR antagonist with Ki values ranging in 0.05 to 0.16 nM for the cloned human M1-M5 mAChRs. |
| CSN12517 | Tolterodine tartrate | 124937-52-6 | Tolterodine tartrate is a competitive mAchR antagonist possessing both antimuscarinic and antispasmodic properties. |
| CSN12516 | Tolterodine | 124937-51-5 | Tolterodine is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. |
| CSN12543 | rel-(1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide xhydrate | 139404-48-1 | Tiotropium bromide is an anticholinergic and bronchodilator and a muscarinic receptor antagonist. |
| CSN12534 | Tiotropium Bromide | 136310-93-5 | Tiotropium bromide is amAChR antagonist which acts through blocking the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. |
| CSN18253 | Tarafenacin | 385367-47-5 | Tarafenacin is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor. |
| CSN17505 | Tarafenacin D-tartrate | 1159101-48-0 | Tarafenacin D-tartrate is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor. |
| CSN16202 | Solifenacin Succinate | 242478-38-2 | Solifenacin succinate is a muscarinic receptor antagonist. Solifenacin succinate is a competitive and selective M3 receptor antagonist with elimination half-life of 45 to 68 hours. |
| CSN18042 | Solifenacin HCl | 180468-39-7 | Solifenacin HCl is a muscarinic receptor antagonist. |
| CSN15789 | 1-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-Acetoxy-3-hydroxy-10,13-dimethyl-2-morpholinohexadecahydro-1H-cyclopenta[a]phenanthren-16-yl)-1-allylpyrrolidin-1-ium bromide | 119302-91-9 | Rocuronium bromide is an aminosteroid non-depolarizing neuromuscular blocker. |
| CSN18122 | Rivanicline oxalate | 220662-95-3 | RJR-2403 oxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM), showing > 1,000 fold selectivity than α7 receptors (Ki= 36000 nM). |
| CSN17930 | Rivanicline | 15585-43-0 | RJR-2403 is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM) showing > 1,000 fold selectivity than α7 receptors (Ki= 36000 nM). |
| CSN19275 | RJR-2403 Hemioxalate | 2095433-95-5 | RJR-2403 hemioxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM), and > 1,000 fold selectivity than α7 receptors (Ki= 36000 nM). |
| CSN12554 | Pregnenolone | 145-13-1 | Pregnenolone is an endogenous steroid hormone synthesized from cholesterol which can act either as a neuroactive steroid or as a prohormone for progestogens, mineralocorticoids, glucocorticoids, androgens, estrogens, and the neuroactive steroids. |
| CSN19032 | PNU-282987 S enantiomer | 737727-12-7 | PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987 free base. PNU-282987 is an α7 nicotinic acetylcholine receptor (α7 nAChR) agonist. |
| CSN17602 | (R)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride | 123464-89-1 | PNU-282987 is a selective α7 nAChR agonist with ki value of 26nM and displays almost no effect on α1β1γδ and α3β4 nAChRs. |
| CSN16715 | Pancuronium dibromide | 15500-66-0 | Pancuronium dibromide is a competitive nAchR antagonist, causing skeletal muscle relaxation and paralysis through competitively binding to the nicotinic receptor at the neuromuscular junction. |
| CSN16263 | Otilonium bromide | 26095-59-0 | Otilonium bromide is an mAchR antagonist used world-wide for the treatment of irritable bowel syndrome. |
| CSN19033 | Monepantel | 887148-69-8 | Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits. |
| CSN16311 | mAChR-IN-1 | 119391-56-9 | mAChR-IN-1 is a potent muscarinic cholinergic receptor (mAChR) antagonist with IC50 of 17 nM. |
| CSN17590 | MK-7622 | 1227923-29-6 | M1 receptor modulator is a muscarinic M1 receptor positive allosteric modulator. |
| CSN16587 | LY2119620 | 886047-22-9 | LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. |
| CSN19385 | Isoimperatorin | 482-45-1 | Isoimperatorin is a natural occuring acetylcholinesterase inhibitor with IC50 value of 74.6μM, extracted from Angelica dahurica and Angelica koreana. |
| CSN13915 | Ipratropium bromide hydrate | 66985-17-9 | Ipratropium bromide is a medication which opens up the medium and large airways in the lungs. |
| CSN18004 | Imidafenacin | 170105-16-5 | Imidafenacin is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM and less potent for M2 receptors (IC50=4.13 nM). |
| CSN13182 | GTS-21 2HCl | 156223-05-1 | GTS-21 2HCl is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. |
| CSN13626 | Encenicline | 550999-75-2 | EVP-6124 is a partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) and shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs. |
| CSN16494 | Encenicline HCl | 550999-74-1 | EVP-6124 HCl is a partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). |
| CSN18998 | DREADD agonist 21 | 56296-18-5 | DREADD agonist 21 is a potent muscarinic DREADD agonist with pEC50 values of 8.91, 8.48 and 7.77 for hM1Dq, hM3Dq and hM4Di, respectively. |
| CSN12749 | Diphenidol HCl | 3254-89-5 | Diphenidol HCl is a non-selective mAchR antagonist and also works as a non-specific inhibitor of voltage-gated ion channels (Na+, K+, and Ca2+) in neurons. |
| CSN16721 | Dinotefuran | 165252-70-0 | Dinotefuran is the third generation of neonicotinoid group,which works through inhibiting nAchRs. |
| CSN16149 | (S)-2-(1-(2-(2,3-Dihydrobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide hydrobromide | 133099-07-7 | Darifenacin hydrobromide is a M3-selective antagonist with pKi of 8.9, an anticholinergic and antispasmotic agent used to treat urinary incontinence and overactive bladder syndrome. |
| CSN17915 | rel-(2R,3'R)-2-Methyl-1'-azaspiro[[1,3]oxathiolane-5,3'-bicyclo[2.2.2]octane] hydrochloride hydrate (2:2:1) | 153504-70-2 | Cevimeline HCl, a muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. |
| CSN17444 | rel-(2R,3'R)-2-Methyl-1'-azaspiro[[1,3]oxathiolane-5,3'-bicyclo[2.2.2]octane] hydrochloride | 107220-28-0 | Cevimeline HCl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors and used in the treatment of dry mouth associated with sjogren's syndrome. |
| CSN16245 | Catharanthine | 2468-21-5 | Catharanthine showed muscarinic antagonism at 10 μM and fully inhibited nicotinic receptor mediated diaphragm contractions with an IC50 of 59.6 μM. As a precursor of the anti-tumor drugs vinblastine and vincristine, it also works as an inhibitor of tubulin self-assembly into microtubules. |
| CSN18747 | Benzetimide HCl | 5633-14-7 | Benzetimide HCl is a muscarinic acetylcholine receptor antagonist. |
| CSN16775 | Atracurium besylate | 64228-81-5 | Atracurium besylate is a non-depolarizing neuromuscular blocking agent with short duration of action. |
| CSN16831 | 3-(Piperidin-2-yl)pyridine | 13078-04-1 | Anabasine is a pyridine and piperidine alkaloid found in the tree tobacco plant, a close relative of the common tobacco plant. |
| CSN16745 | Adiphenine HCl | 50-42-0 | Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug. |
| CSN17103 | Methacholine chloride | 62-51-1 | Acetyl-β-methylcholine chloride is a quaternary ammonium parasympathomimetic agent targeting on mAchR. |
| CSN17376 | A-867744 | 1000279-69-5 | A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. |
| CSN19003 | (-)-Cevimeline hydrochloride hemihydrate | N/A | (-)-Cevimeline HCl, a muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. |
| CSN19002 | (+)-Cevimeline hydrochloride hemihydrate | 1462862-74-3 | (+)-Cevimeline HCl, a muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. |
