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Akt
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN21870 | ((2R,3S,4R,5R)-5-(3-Amino-5-methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate | 61966-08-3 | Triciribine Phosphate is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively. |
| CSN12111 | Tomatidine | 77-59-8 | Tomatidine, a natural product isolated and purified from the fruits of Lycopersicon esculentum Mill., shows antibiotic activity against small-colony variants of S. aureus, significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. It also inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB. |
| CSN16545 | TIC10 isomer | 41276-02-2 | TIC10 isomer is an isomer of TIC10, a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. |
| CSN15801 | TIC10 | 1616632-77-9 | TIC10 is a brain-permeable and pharmacokinetics-improved Akt inhibitor, also inactivates ERK. |
| CSN22511 | Solenopsin | 137038-57-4 | Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM . |
| CSN16878 | SC79 | 305834-79-1 | SC79 is a unique specific Akt activator that may be used to enhance Akt activity in various physiological and pathological conditions. |
| CSN18511 | SC66 | 871361-88-5 | SC66 is an allosteric and dual-inhibitory-function inhibitor of Akt which can lead to a reduction in total and phospho-AKT levels. |
| CSN16251 | Psoralidin | 18642-23-4 | Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L. with anticancer and chemopreventive properties, inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation. |
| CSN16310 | PHT-427 | 1191951-57-1 | PHT-427 is dual inhibitor of Akt and PDPK1 with Ki of 2.7 μM and 5.2 μM, respectively, targeting PH domains of Akt and PDPK1. |
| CSN13863 | Phellopterin | 2543-94-4 | Phellopterin, a natural product isolated and purified from the roots of Saposhnikovia divaricata, is a partial agonist of the central benzodiazepine receptors in vitro, shows cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM, and reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium. |
| CSN19951 | Phellodendrine chloride | 104112-82-5 | Phellodendrine HCl, a natural product isolated and purified from the cortex Phellodendri chinensis with anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. Phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway. |
| CSN11682 | Perifosine | 157716-52-4 | Perifosine is an Akt inhibitor with IC50 of 4.7 μM, targets pleckstrin homology domain of Akt. |
| CSN11644 | Pachymic acid | 29070-92-6 | Pachymic acid is a lanostrane-type triterpenoid, which possesses anti-emetic, anti-inflammatory, and anti-cancer properties. |
| CSN13651 | Nortrachelogenin | 34444-37-6 | Nortrachelogenin, a natural product isolated and purified from the herbs of Trachelospermum jasminoides, shows effects on the central nervous system producing depression in rabbits and is an agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors (GFRs), thereby efficiently synergizing with TRAIL exposure. |
| CSN16135 | Nitidine chloride | 13063-04-2 | Nitidine Chloride can inhibit proliferation and induce apoptosis via the Akt pathway, derived from genus Zanthoxylum. |
| CSN21078 | M2698 | 1379545-95-5 | MSC2363318A, also known as M2698, is an orally available inhibitor of the serine/threonine protein kinases ribosomal protein S6 Kinase (p70S6K) and Akt (protein kinase B), with potential antineoplastic activity. |
| CSN26580 | MK-2206 | 1032349-77-1 | MK-2206 is an orally active, highly potent and selective allosteric Akt inhibitor, with IC50s of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. Many breast cancer cell lines, and PIK3CA-mutant and cell lines with PTEN loss are sensitive to MK-2206. Anticancer activities[1][2]. |
| CSN15705 | MK-2206 dihydrochloride | 1032350-13-2 | MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively, showing no inhibitory activities against 250 other protein kinases observed. |
| CSN16767 | Miltefosine | 58066-85-6 | Miltefosine is a mult-target inhibitor which can inhibit Akt, PI3K and PKC. |
| CSN17777 | Samotolisib | 1386874-06-1 | LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK with an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1 (pT308), Akt1 (pS473), P70S6 (pT389), S6RP (pS240/242). |
| CSN14412 | Hirsutenone | 41137-87-5 | Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM. |
| CSN13165 | GSK-690693 | 937174-76-0 | GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. |
| CSN13834 | Uprosertib | 1047634-65-0 | GSK2141795 is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, |
| CSN17426 | Uprosertib hydrochloride | 1047635-80-2 | GSK2141795 HCl is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively. |
| CSN19148 | GSK2110183 analog 1 hydrochloride | 2070009-64-0 | GSK2110183 HCl is an orally bioavailable, selective, ATP-competitive and potent pan-Akt inhibitor with IC50s of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively. |
| CSN17425 | GSK2110183 analog 1 | 1047634-63-8 | GSK2110183 analog is an analog of GSK2110183. |
| CSN15783 | Ipatasertib | 1001264-89-6 | GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA. |
| CSN17787 | Ipatasertib dihydrochloride | 1396257-94-5 | GDC-0068 2HCl is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA. |
| CSN24612 | FPA-124 | 902779-59-3 | FPA 124 is an inhibitor of Akt/PKB with IC50 of 100 nM that interacts with the PH and kinase domains. |
| CSN10218 | Ethyl gallate | 831-61-8 | Ethyl gallate is a natural product isolated and purifeid from the herbs of Coriaria nepalensis, and it can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9/MMP-2, phosphorylation of Akt and protein expression of NF-κB. |
| CSN13985 | Deguelin | 522-17-8 | Deguelin is a naturally occuring Akt inhibitor purified from the herbs of Derris robusta, which downregulates Akt phosphorylation and shows anticancer effect. |
| CSN25303 | CCT128930 hydrochloride | 2453324-32-6 | CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase. |
| CSN15730 | CCT128930 | 885499-61-6 | CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase. |
| CSN26175 | Borussertib | 1800070-77-2 | Borussertib is covalent-allosteric inhibitor of Akt with an IC50 of 0.8 nM and Ki of 2.2 nM. |
| CSN18817 | BAY1125976 | 1402608-02-9 | BAY1125976 is a selective allosteric AKT1/2 inhibitor and inhibits AKT1 and AKT 2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively. |
| CSN13769 | Capivasertib | 1143532-39-1 | AZD5363 is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively. |
| CSN16097 | AT7867 | 857531-00-1 | AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, exhibiting little activity outside the AGC kinase family. |
| CSN17845 | AT7867 dihydrochloride | 1431697-86-7 | AT7867 HCl is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, and displaying little activity outside the AGC kinase family. |
| CSN13758 | AT13148 | 1056901-62-2 | AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. |
| CSN17685 | Miransertib | 1313881-70-7 | ARQ-092 is an orally bioavailable, selective, and potent allosteric Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. |
| CSN19250 | Miransertib hydrochloride | 1313883-00-9 | ARQ 092 is a pan-Akt inhibitor with IC50 values of 5nM, 4.5nM and 16nM for Akt1, Akt2 and Akt3, respectively, through blocking membrane translocation of inactive AKT and even dephosphorylating the membrane-associated active form. |
| CSN22684 | API-1 | 36707-00-3 | API-1 is a selective Akt/PKB inhibitor and shows antitumor activity. |
| CSN18535 | Akt1 and Akt2-IN-1 | 893422-47-4 | Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity. |
| CSN18455 | AKT Kinase Inhibitor | 842148-40-7 | AKT kinase inhibitor is a compound with potent Akt inhibition activity. |
| CSN17274 | PF-AKT400 | 1004990-28-6 | AKT inhibitor is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50 = 0.5 nM) than PKA (IC50=450 nM). |
| CSN17427 | Afuresertib | 1047644-62-1 | Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. |
| CSN15693 | Afuresertib hydrochloride | 1047645-82-8 | Afuresertib HCl is a potent pan-Akt inhibitor with Ki values of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. |
| CSN16733 | A-674563 | 552325-73-2 | A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM. It also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. |
| CSN19145 | A-674563 hydrochloride | 2070009-66-2 | A-674563 HCl is a potent and selective Akt1 inhibitor with Ki of 11 nM. |
| CSN18330 | A-443654 | 552325-16-3 | A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines. |
