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Akt
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN21870 | Triciribine Phosphate | 61966-08-3 | Triciribine Phosphate is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively. |
| CSN22511 | Solenopsin | 137038-57-4 | Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM . |
| CSN18511 | SC66 | 871361-88-5 | SC66 is an allosteric and dual-inhibitory-function inhibitor of Akt which can lead to a reduction in total and phospho-AKT levels. |
| CSN16251 | Psoralidin | 18642-23-4 | Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L. with anticancer and chemopreventive properties, inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation. |
| CSN13863 | Phellopterin | 2543-94-4 | Phellopterin, a natural product isolated and purified from the roots of Saposhnikovia divaricata, is a partial agonist of the central benzodiazepine receptors in vitro, shows cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM, and reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium. |
| CSN19951 | Phellodendrine HCl | 104112-82-5 | Phellodendrine HCl, a natural product isolated and purified from the cortex Phellodendri chinensis with anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. Phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway. |
| CSN11682 | Perifosine | 157716-52-4 | Perifosine is an Akt inhibitor with IC50 of 4.7 μM, targets pleckstrin homology domain of Akt. |
| CSN11644 | Pachymic Acid | 29070-92-6 | Pachymic acid is a lanostrane-type triterpenoid, which possesses anti-emetic, anti-inflammatory, and anti-cancer properties. |
| CSN13651 | Nortrachelogenin | 34444-37-6 | Nortrachelogenin, a natural product isolated and purified from the herbs of Trachelospermum jasminoides, shows effects on the central nervous system producing depression in rabbits and is an agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors (GFRs), thereby efficiently synergizing with TRAIL exposure. |
| CSN16135 | Nitidine Chloride | 13063-04-2 | Nitidine Chloride can inhibit proliferation and induce apoptosis via the Akt pathway, derived from genus Zanthoxylum. |
| CSN16767 | Miltefosine | 58066-85-6 | Miltefosine is a mult-target inhibitor which can inhibit Akt, PI3K and PKC. |
| CSN14412 | Hirsutenone | 41137-87-5 | Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM. |
| CSN24612 | FPA 124 | 902779-59-3 | FPA 124 is an inhibitor of Akt/PKB with IC50 of 100 nM that interacts with the PH and kinase domains. |
| CSN10218 | Ethyl Gallate | 831-61-8 | Ethyl gallate is a natural product isolated and purifeid from the herbs of Coriaria nepalensis, and it can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9/MMP-2, phosphorylation of Akt and protein expression of NF-κB. |
| CSN13985 | Deguelin | 522-17-8 | Deguelin is a naturally occuring Akt inhibitor purified from the herbs of Derris robusta, which downregulates Akt phosphorylation and shows anticancer effect. |
| CSN17685 | ARQ 092 Free Base | 1313881-70-7 | ARQ-092 is an orally bioavailable, selective, and potent allosteric Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. |
| CSN19250 | ARQ 092 | 1313883-00-9 | ARQ 092 is a pan-Akt inhibitor with IC50 values of 5nM, 4.5nM and 16nM for Akt1, Akt2 and Akt3, respectively, through blocking membrane translocation of inactive AKT and even dephosphorylating the membrane-associated active form. |
| CSN17274 | AKT Inhibitor | 1004990-28-6 | AKT inhibitor is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50 = 0.5 nM) than PKA (IC50=450 nM). |
