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Akt

Akt

货号 产品名 CAS号 信息
CSN10320 Triciribine 35943-35-2 Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.
CSN12111 Tomatidine 77-59-8 Tomatidine, a natural product isolated and purified from the fruits of Lycopersicon esculentum Mill., shows antibiotic activity against small-colony variants of S. aureus, significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. It also inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-κB.
CSN16545 TIC10 Isomer 41276-02-2 TIC10 isomer is an isomer of TIC10, a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
CSN15801 TIC10 1616632-77-9 TIC10 is a brain-permeable and pharmacokinetics-improved Akt inhibitor, also inactivates ERK.
CSN22511 Solenopsin 137038-57-4 Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM .
CSN16878 SC79 305834-79-1 SC79 is a unique specific Akt activator that may be used to enhance Akt activity in various physiological and pathological conditions.
CSN18511 SC66 871361-88-5 SC66 is an allosteric and dual-inhibitory-function inhibitor of Akt which can lead to a reduction in total and phospho-AKT levels.
CSN16310 PHT-427 1191951-57-1 PHT-427 is dual inhibitor of Akt and PDPK1 with Ki of 2.7 μM and 5.2 μM, respectively, targeting PH domains of Akt and PDPK1.
CSN13863 Phellopterin 2543-94-4 Phellopterin, a natural product isolated and purified from the roots of Saposhnikovia divaricata, is a partial agonist of the central benzodiazepine receptors in vitro, shows cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM, and reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.
CSN11682 Perifosine 157716-52-4 Perifosine is an Akt inhibitor with IC50 of 4.7 μM, targets pleckstrin homology domain of Akt.
CSN13651 Nortrachelogenin 34444-37-6 Nortrachelogenin, a natural product isolated and purified from the herbs of Trachelospermum jasminoides, shows effects on the central nervous system producing depression in rabbits and is an agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors (GFRs), thereby efficiently synergizing with TRAIL exposure.
CSN16135 Nitidine Chloride 13063-04-2 Nitidine Chloride can inhibit proliferation and induce apoptosis via the Akt pathway, derived from genus Zanthoxylum.
CSN15705 MK-2206 2HCl   1032350-13-2 MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively, showing no inhibitory activities against 250 other protein kinases observed.
CSN16767 Miltefosine 58066-85-6 Miltefosine is a mult-target inhibitor which can inhibit Akt, PI3K and PKC.
CSN14412 Hirsutenone 41137-87-5 Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM.
CSN13985 Deguelin 522-17-8 Deguelin is a naturally occuring Akt inhibitor purified from the herbs of Derris robusta, which downregulates Akt phosphorylation and shows anticancer effect.
CSN25303 CCT128930 HCl   2453324-32-6 CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase.
CSN15730 CCT128930 885499-61-6 CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase.
CSN22684 API-1 36707-00-3 API-1 is a selective Akt/PKB inhibitor and shows antitumor activity.
CSN16733 A-674563 552325-73-2 A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM. It also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
CSN10945 3CAI 28755-03-5 3CAI is a potent allosteric and specific AKT inhibitor, which exerts efficacy in vitro and in vivo.
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