Aldehyde dehydrogenases | Metabolic Enzyme| CSNpharm

ALDH

ALDH
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货号	产品名	CAS号	信息
CSN15746	NCT-501	1802088-50-1	NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 > 57 μM).
CSN10460	Disulfiram	97-77-8	Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram acts as an allosteric inhibitor of MERS-CoV PLpro but as a competitive (or mixed) inhibitor of SARS-CoV PLpro.
CSN25276	CM10	692269-09-3	CM10 is an ALDH1A inhibitor that depletes CD133+ cancer stem cells.
CSN23590	3,4-Dihydroxyphenylacetic acid	102-32-9	3,4-Dihydroxyphenylacetic Acid is a metabolite of dopamine, it can modulate the aldehyde dehydrogenase (ALDH) activity and protects the cells from the acetaldehyde-induced cytotoxicity in vitro.