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AMPK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN18969 | ZLN024 HCl | 1883548-91-1 | ZLN024 HCl is an AMPK allosteric activator and activates α1β1γ1 and α2β1γ1 by around 2–2.5 fold with an EC50 of about 1–2 μM. |
| CSN23058 | PT 1 | 331002-70-1 | PT 1 is a AMP-activated protein kinase (AMPK) activator. |
| CSN15574 | Phillyrin | 487-41-2 | Phillyrin is a naturally occuring AMPK activity enhancer, isolated and purified from the fruits of Forsythia suspensa. |
| CSN11690 | Phenformin HCl | 834-28-6 | Phenformin HCl is an AMPK activator which can increase the phosphorylation and activation of AMPKalpha1 and AMPKalpha2. |
| CSN20178 | Mogroside IIIE | 88901-37-5 | Mogroside IIIE a naturally occuring cucurbitane glycoside which can attenuate gestational diabetes mellitus through activating of AMPK signaling pathway in mice. |
| CSN16694 | Metformin HCl | 1115-70-4 | Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). |
| CSN19218 | GSK621 | 1346607-05-3 | In AML cell lines and primary AML samples, GSK621 markedly increases phosphorylation at AMPKα T172, a marker of AMPK activation. |
| CSN13424 | Dorsomorphin | 866405-64-3 | Dorsomorphin is a selective AMPK inhibitor with Ki value of 109 nM. |
| CSN15887 | Dorsomorphin 2HCl | 1219168-18-9 | Dorsomorphin 2HCl is a selective AMPK inhibitor with Ki value of 109 nM. |
| CSN27725 | COH-SR4 | 73439-19-7 | COH-SR4 is an AMPK activator with anticancer properties. It significantly inhibited adipocyte differentiation in a dose-dependent manner in 3T3-L1 cells. It significantly reduced intracellular lipid accumulation and downregulated the expression of key adipogenesis-related transcription factors and lipogenic proteins in differentiating adipocytes. |
| CSN21108 | Chitosan oligosaccharide COS | 148411-57-8 | Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways. |
| CSN23079 | RSVA 405 | 140405-36-3 | AMPK activator; also STAT3 inhibitor |
| CSN27358 | Amarogentin | 21018-84-8 | Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK. |
| CSN23366 | Adenosine 5'-monophosphate, disodium salt | 4578-31-8 | Adenosine 5'-monophosphate disodium salt is an activator of AMPK and can be used as a substrate of AMP-thymidine kinase, AMP deaminase and 5′-nucleotidase. |
| CSN12424 | A-769662 | 844499-71-4 | A-769662 is a reverible and allosteric activator of AMPK through inhibiting dephosphorylation of AMPK on Thr-172. |
| CSN17102 | 1,8-Dihydroxyanthraquinone | 117-10-2 | 1,8-Dihydroxyanthraquinone is a synthetic anthraquinone derivative, currently used as an antioxidant in synthetic lubricants, in the synthesis of antitumor agents, as a fungicide and as an intermediate for making dyes. |
