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AMPK

AMPK

货号 产品名 CAS号 信息
CSN18969 ZLN024 HCl 1883548-91-1 ZLN024 HCl is an AMPK allosteric activator and activates α1β1γ1 and α2β1γ1 by around 2–2.5 fold with an EC50 of about 1–2 μM.
CSN23058 PT 1 331002-70-1 PT 1 is a AMP-activated protein kinase (AMPK) activator.
CSN15574 Phillyrin 487-41-2 Phillyrin is a naturally occuring AMPK activity enhancer, isolated and purified from the fruits of Forsythia suspensa.
CSN11690 Phenformin HCl 834-28-6 Phenformin HCl is an AMPK activator which can increase the phosphorylation and activation of AMPKalpha1 and AMPKalpha2.
CSN20178 Mogroside IIIE 88901-37-5 Mogroside IIIE a naturally occuring cucurbitane glycoside which can attenuate gestational diabetes mellitus through activating of AMPK signaling pathway in mice.
CSN16694 Metformin HCl   1115-70-4 Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).
CSN19218 GSK621 1346607-05-3 In AML cell lines and primary AML samples, GSK621 markedly increases phosphorylation at AMPKα T172, a marker of AMPK activation.
CSN13424 Dorsomorphin 866405-64-3 Dorsomorphin is a selective AMPK inhibitor with Ki value of 109 nM.
CSN15887 Dorsomorphin 2HCl 1219168-18-9 Dorsomorphin 2HCl is a selective AMPK inhibitor with Ki value of 109 nM.
CSN27725 COH-SR4   73439-19-7 COH-SR4 is an AMPK activator with anticancer properties. It significantly inhibited adipocyte differentiation in a dose-dependent manner in 3T3-L1 cells. It significantly reduced intracellular lipid accumulation and downregulated the expression of key adipogenesis-related transcription factors and lipogenic proteins in differentiating adipocytes.
CSN21108 Chitosan oligosaccharide COS 148411-57-8 Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.
CSN23079 RSVA 405 140405-36-3 AMPK activator; also STAT3 inhibitor
CSN27358 Amarogentin 21018-84-8 Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK.
CSN23366 Adenosine 5'-monophosphate, disodium salt 4578-31-8 Adenosine 5'-monophosphate disodium salt is an activator of AMPK and can be used as a substrate of AMP-thymidine kinase, AMP deaminase and 5′-nucleotidase.
CSN12424 A-769662 844499-71-4 A-769662 is a reverible and allosteric activator of AMPK through inhibiting dephosphorylation of AMPK on Thr-172.
CSN17102 1,8-Dihydroxyanthraquinone 117-10-2 1,8-Dihydroxyanthraquinone is a synthetic anthraquinone derivative, currently used as an antioxidant in synthetic lubricants, in the synthesis of antitumor agents, as a fungicide and as an intermediate for making dyes.
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