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Amyloid-β

Amyloid-β

货号 产品名 CAS号 信息
CSN13757 Tramiprosate 3687-18-1 Tramiprosate targets soluble Aβ to decrease amyloid plaque deposition and maintains Aβ in a non-fibrillar form.
CSN18386 K 01-162 677746-25-7 K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.
CSN23629 HP-β-CD 128446-35-5 HP-β-CD is used to improve the solubility of lipophilic drugs. It is also an inhibitor of amyloid-β aggregation and Aβ-induced toxicity.
CSN19488 Ginsenoside Re 52286-59-6 Ginsenoside Re is a panaxatriol saponin that has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions.
CSN11056 Frentizole 26130-02-9 Frentizole, an immunosuppressive drug, is an inhibitor of the Aβ-ABAD interaction.
CSN17194 FPS-ZM1 945714-67-0 FPS-ZM1 is a high-affinity RAGE-specific inhibitor that blocks Aβ binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells.
CSN11884 EUK 134 81065-76-1 EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
CSN23259 CRANAD 2 1193447-34-5 CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time.
CSN27216 Colivelin TFA N/A Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury .
CSN17400 ARN2966 102212-26-0 ARN2966 is a potent post-transcriptional modulator of APP expression and reduces expression of APP with resultant lower production of Aβ.
CSN19128 Amyloid P-IN-1 1819986-22-5 Amyloid P-IN-1 is a potential compound for treating amyloidosis, Alzheimer's disease, type 2 diabetes mellitus and osteoarthritis.
CSN21167 Aftin-4 866893-90-5 Aftin-4 is a potent and selective Aβ42 inducer with an EC50 of 30 μM.
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