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Amyloid-β

Amyloid-β

货号 产品名 CAS号 信息
CSN13757 Tramiprosate 3687-18-1 Tramiprosate targets soluble Aβ to decrease amyloid plaque deposition and maintains Aβ in a non-fibrillar form.
CSN15667 Spinosin 72063-39-9 Spinosin is a flavone C-glycoside which can be isolated from the seeds of Zizyphus jujuba with anxiolytic-like effects. Spinosin could ameliorate memory impairment induced through Aβ.
CSN16909 Semagacestat 425386-60-3 Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM.
CSN11902 Sciadopitysin 521-34-6 Sciadopitysin, a natural product isolated and purified from the leaves of Ginkgo biloba L., can inhibit the Aβ aggregation and reduce Aβ-induced toxicity in the primary cortical neurons.
CSN24621 Ro 90-7501 293762-45-5 Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly, it can reduce Aβ42-induced toxicity with EC50 of 2 μM.
CSN20304 PE859 1402727-29-0 PE859 is a Curcumin-derived inhibitor of Amyloid-β and Tau aggregation and can ameliorate cognitive dysfunction in senescence-accelerated mouse Prone 8.
CSN24622 NQTrp 185351-19-3 NQTrp is an effective inhibitor of Aβ oligomer and fibril formation with IC50 of 50 nM for formation of fibrils from Aβ1-42.
CSN21321 MK-3328 1201323-97-8 MK-3328 is a β-Amyloid PET ligand, which exhibits high binding potency with an IC50 of 10.5 nM.
CSN13820 MK-0752 471905-41-6 MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM.
CSN24623 LPYFD-NH2 700361-48-4 LPYFD-NH2 is a neuroprotective peptide that binds to amyloid beta (Aβ). It protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo.
CSN18386 K 01-162 677746-25-7 K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.
CSN26583 γ-Secretase modulator 4 1420200-82-3 in human and mouse, respectively[1].
CSN23629 (2-Hydroxypropyl)-β-cyclodextrin 128446-35-5 HP-β-CD is used to improve the solubility of lipophilic drugs. It is also an inhibitor of amyloid-β aggregation and Aβ-induced toxicity.
CSN19488 Ginsenoside Re 52286-59-6 Ginsenoside Re is a panaxatriol saponin that has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions.
CSN11056 Frentizole 26130-02-9 Frentizole, an immunosuppressive drug, is an inhibitor of the Aβ-ABAD interaction.
CSN17194 FPS-ZM1 945714-67-0 FPS-ZM1 is a high-affinity RAGE-specific inhibitor that blocks Aβ binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells.
CSN11884 EUK-134 81065-76-1 EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
CSN23229 Edonerpic maleate 519187-97-4 Edonerpic maleate can inhibit amyloid-β peptides (Aβ) and used as a neurotrophic agent.
CSN21120 MDR-1339 1018946-38-7 DWK-1339 is an orally active and blood-brain-barrier-permeable Aβ-aggregation inhibitor, used in the research of Alzheimer's disease.
CSN23259 CRANAD-2 1193447-34-5 CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time.
CSN27216 Colivelin TFA 2803948-60-7 Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury .
CSN17400 ARN2966 102212-26-0 ARN2966 is a potent post-transcriptional modulator of APP expression and reduces expression of APP with resultant lower production of Aβ.
CSN32711 Valiltramiprosate 1034190-08-3 Amyloid-beta (Abeta) Protein Aggregation Inhibitors, Antiamyloidogenic Agents
CSN32715 (R)-2-(2-Amino-3-(1H-indol-3-yl)propanamido)-2-methylpropanoic acid 1123071-24-8 Amyloid-beta (Abeta) Protein Aggregation Inhibitors, Antiamyloidogenic Agents
CSN21486 β-Amyloid (25-35) 131602-53-4 Amyloid β-Protein fragment 25-35 (Aβ25-35) is involved in the pathogenesis of alzheimer′s disease and it has neurotoxic activities to cultured cells.
CSN19128 amyloid P-IN-1 1819986-22-5 Amyloid P-IN-1 is a potential compound for treating amyloidosis, Alzheimer's disease, type 2 diabetes mellitus and osteoarthritis.
CSN21167 Aftin-4 866893-90-5 Aftin-4 is a potent and selective Aβ42 inducer with an EC50 of 30 μM.
CSN22036 4-(6-Bromo-2-benzothiazolyl)benzenamine 566169-97-9 4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome.
CSN21189 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 566169-98-0 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent which binds to Amyloid-β (1-40) with a KD of 1.7 nM.
CSN20235 2-D08 144707-18-6 2-D08 interacts with amyloid β, showing an anti-aggregatory and neuroprotective effect.
CSN84005 Fustin 20725-03-5
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