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DNA alkylator or crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator or crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation.

AP endonuclease

货号 产品名 CAS号 信息
CSN21717 Lucanthone 479-50-5 Lucanthone, thioxanthone-based DNA intercalator, is an inhibitor of DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1).
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