|Ursolic acid, a naturally occurring triterpenoid, induces the apoptosis of human cancer cells through multiple signaling pathways.
|Umbelliferone, a natural product isolated and purified from the herbs of Ruta graveolens L., exhibits significant anticancer effects via the induction of apoptosis, cell cycle arrest and DNA fragmentation in HepG2 cancer cells.
|Ubiquitin Isopeptidase Inhibitor I, G5
|Ubiquitin Isopeptidase Inhibitor I, G5 is an apoptosome-independent caspase and apoptosis activator.
|Trabectedin is an antitumour agent of marine origin with potent antitumour activity both in vitro and in vivo.
|TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
|Taurochenodeoxycholic acid-d5 is a natural product.
|Tasisulam is an antitumor agent and an apoptosis inducer via the intrinsic pathway.
|SMIP004 is an inducer of cancer-cell selective apoptosis of human prostate cancer cells, downregulates SKP2 and stabilizes p27.
|Silvestrol is isolated from the fruits and twigs of Aglaia foveolata, by inducing caspase-3 activation to cause cell death.
|Silvestrol aglycone, an aglycone of potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7 and a 5'myc-UTR-LUC inhibtior (IC50= 0.8 nM).
|Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML).
|Rabeprazole D4 (LY307640 D4) is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux.
|Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin and it is a puromycin analog which does not inhibit protein synthesis but induces apoptosis.. Puromycin aminonucleoside is a reversible inhibitor of dipeptidyl peptidase II and cytosol alanyl aminopeptidase.
|NSC348884 is a nucleophosmin (NPM) inhibitor, inhibits cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.
|Notopterol induces apoptosis and inhibits cell cycle-specific, it's a natural product isolated and purified from the roots of Notopterygium incisum.
|Myristicin is a natural product found in spices and umbelliferous plants. It induces apoptosis in leukemia cells, decreases pro-inflammatory cytokine expression in alveolar epithelial cells, and suppresses growth of Clostridium, Enterococcus, Candida.
|Morin, a natural product isolated and purified from the root bark of Morus alba L., induces caspase-dependent apoptosis through extrinsic pathway by upregulating Fas receptor as well as through the intrinsic pathway by modulating Bcl-2 and IAP family members, and ROS generation.
|Methyl protodioscin is a furostanol bisglycoside with antitumor properties and shows to reduce proliferation, cause cell cycle arrest. It inhibited proliferation and promoted apoptosis of pancreatic cancer.
|Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM.
|Karanjin, a natural product isolated and purified from the seeds of the karanja tree (Millettia pinnata or Pongamia glabra Vent.), has an effects on cell cycle arrest and apoptosis in human A549, HepG2 and HL-60 cancer cells.
|Isoalantolactone is a naturally occuring sesquiterpene lactone isolated from Inula helenium with a role as an apoptosis inducer, an antifungal agent and a plant metabolite.
|Gynostemma extract, a natural product isolated and purified from the herb of Gynostemma pentaphyllum (Thunb.) Makino., induces apoptosis in human hepatoma cells through the up-regulation of Bax and Bak, and down-regulation of Bcl-2, release of mitochondrial cytochrome c and activation of caspase cascade, induces ER stress and production of reactive oxygen species and Ca 2+ , changes the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, and causes cytochrome c release, activation of caspase-3 before leading to apoptosis.
|Glaucocalyxin A can inhibit cell proliferation and promote apoptosis. It is extracted from the herbs of rabdosia rubescens.
|Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC50 range of 12-54 µM and shows neuroprotective and anti neuronal apoptotic ability.
|Geranyl acetate is a natural organic compound that is used primarily as a component of perfumes for creams and soaps and as a flavoring ingredient.
|Flavokawain B, a chalcone isolated from the root extracts of kava-kava plant, is a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B shows strong antiangiogenic activity and inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations.
|Evodiamine, a natural product isolated and purified from the fruits of Evodia rutaecarpa (Juss.) Benth. with anti-oxidation, anti-inflammatory and anti-cancer effects, is an apoptosis inducer via the AKT pathway and an inhibitor of cancer cells proliferation via inhibition of MTDH expression and activation of apoptosis.
|Episilvestrol is a derivative of Silvestrol, which can induce apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7 and a 5'myc-UTR-LUC inhibtor (IC50= 0.8 nM).
|Dracorhodin perchlorate is a natural product extracted from a natural medicine Dragon's blood. Dracorhodin perchlorate inhibits cell proliferation, induces cell cycle arrest and apoptosis.
|Desacetylcinobufotalin is a natural apoptosis inducer and shows the marked inhibition effect to HepG2 cells and the IC50 value is 0.0279 μmol/mL.
|Columbianadin, a natural product isolated and purified from the herbs of Angelicae pubescens with analgesic, anti-inflammatory, calcium-channel blocking, and platelet aggregation inhibiting functions, can effectively suppress the growth of colon cancer cells, low concentration (up to 25 μM) of CBN induces apoptosis, and high concentration (50 μM) of CBN induces necroptosis, demonstrates that CBN has the potential to be a candidate in the development of anti-cancer agent derived from natural products.
|Cinobufagin, a natural product isolated and purified from the glandular body of Bufo bufo gargarizans Cantor, inhibits the proliferation and induces apoptosis, may be related to the mitochondria-mediated pathway and GSK-3β/NF-κB pathway, can significantly relieve cancer pain in mice and raised their pain threshold, mainly upregulating the expression levels of β -END and μ -OR in the hind paw tumor and adjacent tissue, and act as a potent anticancer agent against MM and possibly exerts its effects through the ROS-mediated activation of ERK, JNK and p38 MAPK leading to the activation of caspase-3 in U266 cells.
|BTR-1 is a rhodanine derivative induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, leading to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death.
|Bleomycin Sulfate is a glycopeptide antitumor antibiotic with antineoplastic efficacy.
|BDE-47 is an apoptosis inducer involving ROS mediated mitochondrial pathway and Nrf2 pathway activation.
|Atractyloside potassium salt
|Atractyloside is a natural compound that acts both an inhibitor of ANT and an apoptosis inducer.
|Apoptosis activator 2 is a potent apoptosis activator which increases procaspase-9 processing and subsequent caspase-3 activation.
|Adarotene is an effective apoptosis inducer and surprisingly produced DNA damage. ST1926 exhibites a potent antiproliferative activity on a large panel of human tumor cells.
|3-O-Acetyloleanolic Acid exhibits anti-angiogenic effects and induces apoptosis in HUVECs and HCT-116 cells, it is a natural product isolated and purified from the herbs of Phytolacca americana.
|2-methoxycinnamaldehyde, found in ceylan cinnamon, is a flavouring ingredient.
|(E)--Dehydroparadol, shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively.
|(20S)-Protopanaxadiol is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin and an apoptosis inducer.
|Bleomycin A5 HCl