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ATM/ATR

ATM/ATR

货号 产品名 CAS号 信息
CSN12216 Wortmannin 19545-26-7 Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. It also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays.
CSN15802 VE-822 1232416-25-9 VE-822 is an ATR inhibitor with IC50 of 19 nM in HT29 cells.
CSN15863 VE-821 1232410-49-9 VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.
CSN12265 PI-103 371935-74-9 PI-103 is a potent inhibitor with low IC50 values against recombinant PI3K isoforms p110alpha (IC50= 2 nM), p110beta (IC50= 3 nM), p110delta (IC50= 3 nM), and p110gamma (IC50= 15 nM), less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. It blocks autophagic flux.
CSN17548 (Z)-Mirin 1198097-97-0 Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.
CSN15844 KU-60019 925701-46-8 KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM.
CSN17114 KU-55933 587871-26-9 KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 2.2 nM, respectively and highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
CSN17142 CP-466722 1080622-86-1 CP-466722, a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.
CSN21930 Chloroquine Phosphate 1446-17-9 Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties and inhibits the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin.
CSN13686 Chloroquine phosphate 50-63-5 Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.
CSN25554 Chloroquine Sulphate 132-73-0 Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.
CSN25650 Chloroquine 54-05-7 Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.
CSN16057 CGK733 905973-89-9 CGK 733 is an inhibitor of ATM and ATR with IC50 of ~200 nM, also induces cell death in prematurely senescent breast cancer cells.
CSN20269 Elimusertib 1876467-74-1 BAY-1895344 is a potent and selective ATR inhibitor with IC50 of 7 nM.
CSN24689 BAY-1895344 HCl N/A BAY-1895344 is a potent and selective ATR inhibitor with IC50 of 7 nM.
CSN17205 Ceralasertib 1352226-88-0 AZD6738 is a highly selective and potent inhibitor of ATR kinase activity with IC50 value of 1nM in isolated enzyme assay and showed inhibitory effect on ATR kinase-dependent cellular Chk1 phosphorylation with IC50 value of 74nM.
CSN23317 AZD1390 2089288-03-7 AZD1390 is an ATM inhibitor with IC50 of 0.78 nM in cells.
CSN18824 AZD0156 1821428-35-6 AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities.
CSN22539 AZ32 2288709-96-4 AZ32 is an ATM inhibitor with IC50 <6.2 nM in enzyme assays and 310 nM in cellular assays.
CSN24807 AZ31 2088113-98-6 AZ31 is a potent and highly selective ATM inhibitor.
CSN22698 AZ 5704 1941214-06-7 AZ 5704 is a potent and selective ATM kinase inhibitor with IC50 of 0.6 nM.
CSN15890 AZ20 1233339-22-4 AZ 20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM exhibiting 8-fold selectivity over mTOR (IC50=38 nM).
CSN26597 Gartisertib 1613191-99-3 ATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity[1][2].
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