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Aurora Kinase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN27599 | SP-146 | N/A | SP-146 is a highly selective and non-ATP-competitive Aurora A/B inhibitor with IC50 values of 0.316nM 18.975 nM for Aurora A and Aurora B, respectively. |
| CSN18798 | SNS-314 Mesylate | 1146618-41-8 | SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. |
| CSN15807 | Reversine | 656820-32-5 | Reversine, a synthetic purine analogue(2,6-disubstituted purine), is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 12 nM/13 nM/20 nM, respectively. |
| CSN12811 | PHA-680632 | 398493-79-3 | PHA-680632 is potent inhibitor of Aurora A, B and C with IC50 of 27 nM, 135 nM and 120 nM, respectively. |
| CSN25344 | NU6140 | 444723-13-1 | NU6140 is a selective CDK2 inhibitor with IC50 value of 0.94μM, as well as potently inhibits Aurora kinase A/B with IC50 values of 0.035 and 0.067μM, respectively. |
| CSN17389 | MK-5108 | 1010085-13-8 | MK-5108 is a potent and highly selective Aurora inhibitor with IC50 of 0.064, 14 and 12 nM for Aurora A, B and C. |
| CSN13761 | Hesperadin | 422513-13-1 | Hesperadin is a potent and ATP-competitive inhibitor of Aurora B kinase with IC50 of 250 nM. |
| CSN17149 | CCT137690 | 1095382-05-0 | CCT137690 is a potent inhibitor of Aurora kinases (IC50 values are 0.015, 0.019 and 0.025 μM at Aurora A, Aurora C and Aurora B respectively). |
| CSN12715 | AT9283 | 896466-04-9 | AT9283 is a multi-targeted inhibitor with IC50s of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl (T315I), JAK2 and JAK3, Aurora A and Aurora B, respectively. |
| CSN16543 | AMG-900 | 945595-80-2 | AMG-900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM, and is > 10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. |
