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Aurora Kinase

Aurora Kinase

货号 产品名 CAS号 信息
CSN12727 ZM-447439 331771-20-1 ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM, 130 nM respectively, > 8 fold selectivity than Aurora C, MEK1, Src.
CSN26598 Tripolin A 1148118-92-6 Tripolin A ((E)-Tripolin A) is a specific non-ATP competitive Aurora A kinase inhibitor, with IC50 values of 1.5 μM and 7 μM for Aurora A and Aurora B, respectively[1].
CSN12326 Tozasertib 639089-54-6 Tozasertib is the inhibitor of Aurora-A, -B, -C kinases with Ki values of 0.6, 18, 4.6 nM respectively.
CSN23149 TC-A 2317 hydrochloride 1245907-03-2 TC-A2317 HCl is an Aurora kinase A inhibitor.
CSN16128 TAK-901 934541-31-8 TAK-901 is an inhibitor of Aurora A/B with IC50 of 21 nM/15 nM.
CSN20031 (Z)-Orantinib 210644-62-5 SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively).
CSN27599 SP-96 2682114-54-9 SP-96 is a highly selective and non-ATP-competitive Aurora A/B inhibitor with IC50 values of 0.316nM 18.975 nM for Aurora A and Aurora B, respectively.
CSN18798 SNS-314 mesylate 1146618-41-8 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively.
CSN13118 SCH-1473759 1094069-99-4 SCH-1473759 is a sub-nanomolar Aurora A/B inhibitor with IC50 of 4 nM and 13 nM, respectively.
CSN17462 SCH-1473759 hydrochloride 1094067-13-6 SCH-1473759 HCl is a sub-nanomolar Aurora A/B inhibitor with IC50 of 4 nM and 13 nM, respectively.
CSN15807 Reversine 656820-32-5 Reversine, a synthetic purine analogue(2,6-disubstituted purine), is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 12 nM/13 nM/20 nM, respectively.
CSN12811 PHA-680632 398493-79-3 PHA-680632 is potent inhibitor of Aurora A, B and C with IC50 of 27 nM, 135 nM and 120 nM, respectively.
CSN18615 PF-03814735 942487-16-3 PF-03814735 is a potent, orally bioavailable, reversible small-molecule Aurora kinase inhibitor with IC50 of 0.8, 5, 10 and 22 nM for Aurora A, Aurora B, Flt 1 and FAk, respectively.
CSN25344 NU6140 444723-13-1 NU6140 is a selective CDK2 inhibitor with IC50 value of 0.94μM, as well as potently inhibits Aurora kinase A/B with IC50 values of 0.035 and 0.067μM, respectively.
CSN12363 MLN8054 869363-13-3 MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM and exhibits more than 40-fold selective for Aurora A than Aurora B.
CSN16817 MK-8745 885325-71-3 MK-8745 is a potent and selective Aurora an inhibitor with IC50 of 0.6 nM, more than 450-fold selectivity for Aurora A over Aurora B.
CSN17389 MK-5108 1010085-13-8 MK-5108 is a potent and highly selective Aurora inhibitor with IC50 of 0.064, 14 and 12 nM for Aurora A, B and C.
CSN13761 Hesperadin 422513-13-1 Hesperadin is a potent and ATP-competitive inhibitor of Aurora B kinase with IC50 of 250 nM.
CSN12395 GSK-1070916 942918-07-2 GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM and displays > 100-fold selectivity against the closely related Aurora A-TPX2 complex (IC50=490 nM).
CSN24802 BPR1K871   2443767-35-7 DBPR114 is a potent multi-kinase inhibitor with potent activities against more than 57 oncogenic kinases, including Aurora-A, FLT3, CSF1R, MET, etc. DBPR114 exhibited favorable PK profiles: a long half-life (t1/2 = 23.5 h), moderate clearance and high volume of distribution. Also DBPR114 can effectively inhibit the growth of human acute myeloid leukemia MOLM-13 and MV4-11, MIA PaCa-2, Hep3B, MKN45, Colo205, and NTUB1 solid tumor xenografts in vivo without causing significant body weight loss.
CSN12423 Danusertib 827318-97-8 Danusertib is a pyrrolo-pyrazole and small molecule Aurora kinases inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively. It is modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc.
CSN17118 CYC-116 693228-63-6 CYC116 is a potent inhibitor of Aurora with Ki of 8.0 nM/9.2 nM for Aurora A/B.
CSN16269 CTX-0294885 1439934-41-4 CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent. CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen.
CSN50650 CD532 1639009-81-6 CD532 is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 also can directly interact with AURKA and induces a global conformational shift. CD532 can be used for the research of cancer.
CSN27200 CCT241736 1402709-93-6 CCT241736 is a dual FLT3/Aurora kinase A/B inhibitor with IC50 values of 0.035μM, 0.015μM and 0.1μM, respectively.
CSN17149 CCT 137690 1095382-05-0 CCT137690 is a potent inhibitor of Aurora kinases (IC50 values are 0.015, 0.019 and 0.025 μM at Aurora A, Aurora C and Aurora B respectively).
CSN16415 CCT129202 942947-93-5 CCT129202 is a Aurora kinase inhibitor with IC50 of 0.042 ± 0.022, 0.198 ± 0.05, and 0.227 ± 0.064 μM for Aurora A, Aurora B, and Aurora C, respectively.
CSN16205 BI-847325 1207293-36-4 BI-847325 is a selective and orally bioavailable dual MEK/Aurora kinase inhibitor with IC50 of 3 nM (Xenopus laevis Aurora B), 25 nM (human Aurora A), 15 nM (human Aurora C), 25 nM (human MEK1), and 4 nM (human MEK2) respectively.
CSN17268 Barasertib-HQPA 722544-51-6 AZD1152-HQPA is the active metabolite of AZD-1152 and a highly selective Aurora B inhibitor with IC50 of 0.37 nM, ~100 fold selective for Aurora B over Aurora A.
CSN23770 Aurora kinase inhibitor-3 879127-16-9 Aurora kinase inhibitor III is a potent ATP-competitive aurora related kinase (also designated ARK) inhibitor with IC50 value of 42 nM for Aurora A kinase.
CSN12380 TCS7010 1158838-45-9 Aurora an inhibitor I is a potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold selective for Aurora A than Aurora B.
CSN12715 AT9283 896466-04-9 AT9283 is a multi-targeted inhibitor with IC50s of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl (T315I), JAK2 and JAK3, Aurora A and Aurora B, respectively.
CSN26521 (Z)-SKI V 927429-51-4 and a Kd of 3.06 μM. (Z)-SKI V inhibits Aurora A with an IC50 of 1.34 μM. (Z)-SKI V, a benzofuran derivative, has extensive cytotoxic effects on cancer cell lines[1].
CSN16543 AMG 900 945595-80-2 AMG-900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM, and is > 10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2.
CSN13457 Alisertib 1028486-01-2 Alisertib is a selective Aurora inhibitor with IC50 of 1.2 nM with > 200-fold higher selectivity for Aurora A than Aurora B.
CSN103809 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea (S)-2-hydroxypropanoate 896466-76-5
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