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Autophagy
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12216 | Wortmannin | 19545-26-7 | Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. It also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays. |
| CSN12203 | Vinorelbine ditartrate | 125317-39-7 | Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. |
| CSN20492 | Urolithin A | 1143-70-0 | Urolithin A is a metabolite of ellagitannin with antiproliferative and antioxidant properties. It can cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease. Urolithin A has been shown to stimulate mitophagy and improve muscle function in aged animals15 and in models of muscular dystrophy,16 while also being safe, bioavailable, and able to induce mitochondrial gene expression in older adults. |
| CSN25238 | UBCS039 | 358721-70-7 | UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes. |
| CSN25367 | Typhaneoside | 104472-68-6 | Typhaneoside, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function. |
| CSN14056 | Tephrosin | 76-80-2 | Tephrosin, a natural product isolated and purified from the herbs of Derris robusta, may be valuable for augmenting the therapeutic efficacy of 2-Deoxy-D-glucose(DG), has potent antitumor activity by inducing autophagy pathway, internalization and degradation of inactivated EGFR and ErbB2, and exerts antitumor effects by inducing internalization and degradation of inactivated EGFR and ErbB2 in human colon cancer cells. |
| CSN11588 | Sulfacetamide Sodium | 127-56-0 | Sulfacetamide sodium is a sulfonamide antibiotic that is used topically to treat skin infections and orally for urinary tract infections. |
| CSN16665 | STF-62247 | 315702-99-9 | STF-62247 is an autophagy inducer in VHL-deficient renal cell carcinoma cells and shows selective toxicity and growth inhibition for cells with VHL deficiency (VHL-) compared to wild-type (VHL+). |
| CSN17766 | SR9011 | 1379686-29-9 | SR9011 is an agonist of REV-ERB with IC50 of 790 nM for REV-ERBα and IC50 = 560 nM for REV-ERBβ. |
| CSN13809 | Spautin-1 | 1262888-28-7 | Spautin-1 is inhibitor of USP10 and USP13 with IC50 of ∼0.6 and 0.7 μM respectively, it's also a potent and specific autophagy inhibitor. |
| CSN23843 | Sofalcone | 64506-49-6 | Sofalcone is an anti-ulcer chalcone derivative, it could induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium. |
| CSN17302 | SMER28 | 307538-42-7 | SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of the mTOR pathway. |
| CSN18619 | SMER18 | 944153-47-3 | SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer. |
| CSN11885 | Salinomycin | 53003-10-4 | Salinomycin, an antibiotic potassium ionophore, is an anti-coccidial drug and an autophagy modulator. It is also an inhibitor of Wnt/β-catenin signaling. |
| CSN26526 | Salicylic acid-d6 | 285979-87-5 | Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1]. |
| CSN20231 | ROC-325 | 1859141-26-6 | ROC-325 is an inhibitor of autophagy with promising anti-leukemic activity, which diminishes AML cell viability with the IC50 range of 0.7-2.2 μM. |
| CSN19356 | Rhein | 478-43-3 | Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling. |
| CSN22494 | QX77 | 1798331-92-6 | QX77 is a chaperone-mediated autophagy (CMA) activator. |
| CSN11779 | Procyanidin B2 | 29106-49-8 | Procyanidin B2 exerts a potent and beneficial role in reducing granulosa cell apoptosis and inducing autophagy process,and exerts a variety of potent protective pharmacological effects on diabetic complications. |
| CSN12265 | PI-103 | 371935-74-9 | PI-103 is a potent inhibitor with low IC50 values against recombinant PI3K isoforms p110alpha (IC50= 2 nM), p110beta (IC50= 3 nM), p110delta (IC50= 3 nM), and p110gamma (IC50= 15 nM), less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. It blocks autophagic flux. |
| CSN16182 | Peiminine | 18059-10-4 | Peiminine, a natural product isolated and purified from the bulbus of Fritillaria thunbergii Miq., is an effective inhibitor for lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury.It induces autophagic cell death thus represses colorectal carcinoma tumor growth. |
| CSN12693 | Niclosamide | 50-65-7 | Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibits the phosphorylation of STAT3 and has no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5). It is also an antiparasitic agent. It induced apoptosis by activating the intrinsic and caspase-independent pathway in human A549 and CL1-5 cells. |
| CSN24043 | Metformin | 657-24-9 | Metformin is a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). |
| CSN16694 | Metformin hydrochloride | 1115-70-4 | Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). |
| CSN22556 | Lys05 | 1391426-24-6 | Lys05 is water soluble salt of Lys01. Lys05 shows potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models. |
| CSN11346 | LY294002 | 154447-36-6 | LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM in cell-free assays. It is an early-stage autophagy inhibitor and also inhibits CK2. |
| CSN26390 | Liensinine | 2586-96-1 | Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, is an autophagy/mitophagy inhibitor and has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc[1]. |
| CSN22904 | IITZ-01 | 1807988-47-1 | IITZ-01 is an inhibitor of lysosomotropic autophagy. It can enhance autophagosome accumulation and inhibit autophagosomal degradation that finally resulting in the inhibition of autophagy. |
| CSN11173 | Hydroxychloroquine sulfate | 747-36-4 | Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9. |
| CSN25649 | Hydroxychloroquine | 118-42-3 | Hydroxychloroquine is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9. |
| CSN29504 | Gemcitabine monophosphate | 116371-67-6 | Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
| CSN26154 | Fluspirilene | 1841-19-6 | Fluspirilene is a relatively long-acting injectable depot antipsychotic drug. It also works as autophagy inducer that inhibits the intracellular flux of calcium, thus removing the activation factor of calpain. And the cleavage of Atg5 is eventually prevented by fluspirilene treatment in a time-course study. |
| CSN25555 | EACC | 864941-31-1 | EACC inhibits autophagic flux by blocking autophagosome-lysosome fusion. It does not have any effect on lysosomal properties or on endocytosis-mediated degradation of EGF receptor. It affects the translocation of SNAREs Stx17 and SNAP29 on autophagosomes without impeding the completion of autophagosomes. |
| CSN13612 | Dihydroartemisinin | 71939-50-9 | Dihydroartemisinin is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua with anti-cancer and antimalarial activities. |
| CSN16598 | Corynoxine | 6877-32-3 | Corynoxine is an enantiomer of Corynoxine B and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells. |
| CSN18014 | Corynoxine B | 17391-18-3 | Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese) and a Beclin-1-dependent autophagy inducer. |
| CSN25554 | Chloroquine Sulphate | 132-73-0 | Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug. |
| CSN25650 | Chloroquine | 54-05-7 | Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug. |
| CSN28416 | CA77.1 | 2412270-22-3 | CA77.1 is a brain-penetrant and orally active chaperone-mediated autophagy activator used to treat for Alzheimer's disease. |
| CSN24767 | CA-5f | 1370032-19-1 | CA-5f is identified as a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. It exhibted potential clinical application for NSCLC therapy. |
| CSN26426 | Brazilin | 474-07-7 | Brazilin, a red dye precursor obtained from the heartwood of several species of tropical hardwoods, inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities. |
| CSN26528 | BGT226 | 915020-55-2 | BGT226 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins. |
| CSN22545 | Autophinib | 1644443-47-9 | Autophinib is an ATP-competitive inhibitor of the VPS34 with IC50 of 19 nM, also inhibitor of starvation- and Rapamycin-induced autophagy with IC50 of 40 and 90 nM respectively. |
| CSN32731 | Autogramin-2 | 2375541-45-8 | Autogramin-2 is a new class of autophagy inhibitor with IC50 value of 0.27 ± 0.09 µM (measured by amino acid starvation induced autophagy) and 0.14 ± 0.08 µM (measured by Rapamycin induced autophagy) through targeting GRAMD1A. |
| CSN23318 | 3BDO | 890405-51-3 | 3BDO is a new mTOR activator which can also inhibit autophagy. |
| CSN38807 | Desethyl chloroquine diphosphate | 247912-76-1 | |
| CSN41327 | Desethyl chloroquine | 1476-52-4 | |
| CSN81683 | Metyrapone Tartrate | 908-35-0 |
