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Autophagy

Autophagy

货号 产品名 CAS号 信息
CSN12216 Wortmannin 19545-26-7 Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. It also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays.
CSN12203 Vinorelbine Ditartrate 125317-39-7 Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals.
CSN20492 Urolithin A 1143-70-0 Urolithin A is a metabolite of ellagitannin with antiproliferative and antioxidant properties. It can cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease. Urolithin A has been shown to stimulate mitophagy and improve muscle function in aged animals15 and in models of muscular dystrophy,16 while also being safe, bioavailable, and able to induce mitochondrial gene expression in older adults.
CSN25238 UBCS039   358721-70-7 UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes.
CSN25367 Typhaneoside 104472-68-6 Typhaneoside, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function.
CSN14056 Tephrosin 76-80-2 Tephrosin, a natural product isolated and purified from the herbs of Derris robusta, may be valuable for augmenting the therapeutic efficacy of 2-Deoxy-D-glucose(DG), has potent antitumor activity by inducing autophagy pathway, internalization and degradation of inactivated EGFR and ErbB2, and exerts antitumor effects by inducing internalization and degradation of inactivated EGFR and ErbB2 in human colon cancer cells.
CSN11588 Sulfacetamide Sodium 127-56-0 Sulfacetamide sodium is a sulfonamide antibiotic that is used topically to treat skin infections and orally for urinary tract infections.
CSN16665 STF-62247 315702-99-9 STF-62247 is an autophagy inducer in VHL-deficient renal cell carcinoma cells and shows selective toxicity and growth inhibition for cells with VHL deficiency (VHL-) compared to wild-type (VHL+).
CSN17766 SR-9011 1379686-29-9 SR9011 is an agonist of REV-ERB with IC50 of 790 nM for REV-ERBα and IC50 = 560 nM for REV-ERBβ.
CSN23843 Sofalcone 64506-49-6 Sofalcone is an anti-ulcer chalcone derivative, it could induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
CSN17302 SMER28 307538-42-7 SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of the mTOR pathway.
CSN18619 SMER18 944153-47-3 SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.
CSN11885 Salinomycin 53003-10-4 Salinomycin, an antibiotic potassium ionophore, is an anti-coccidial drug and an autophagy modulator. It is also an inhibitor of Wnt/β-catenin signaling.
CSN26526 Salicylic acid-D6 285979-87-5 Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].
CSN19356 Rhein 478-43-3 Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling.
CSN11779 Procyanidin B2 29106-49-8 Procyanidin B2 exerts a potent and beneficial role in reducing granulosa cell apoptosis and inducing autophagy process,and exerts a variety of potent protective pharmacological effects on diabetic complications.
CSN16182 Peiminine 18059-10-4 Peiminine, a natural product isolated and purified from the bulbus of Fritillaria thunbergii Miq., is an effective inhibitor for lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury.It induces autophagic cell death thus represses colorectal carcinoma tumor growth.
CSN12693 Niclosamide 50-65-7 Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibits the phosphorylation of STAT3 and has no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5). It is also an antiparasitic agent. It induced apoptosis by activating the intrinsic and caspase-independent pathway in human A549 and CL1-5 cells.
CSN16694 Metformin HCl   1115-70-4 Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).
CSN26390 Liensinine 2586-96-1 Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, is an autophagy/mitophagy inhibitor and has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc[1].
CSN22904 IITZ-01 1807988-47-1 IITZ-01 is an inhibitor of lysosomotropic autophagy. It can enhance autophagosome accumulation and inhibit autophagosomal degradation that finally resulting in the inhibition of autophagy.
CSN11173 Hydroxychloroquine Sulfate 747-36-4 Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9.
CSN25649 Hydroxychloroquine 118-42-3 Hydroxychloroquine is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9.
CSN29504 Gemcitabine monophosphate 116371-67-6 Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
CSN25555 EACC 864941-31-1 EACC inhibits autophagic flux by blocking autophagosome-lysosome fusion. It does not have any effect on lysosomal properties or on endocytosis-mediated degradation of EGF receptor. It affects the translocation of SNAREs Stx17 and SNAP29 on autophagosomes without impeding the completion of autophagosomes.
CSN13612 Dihydroartemisinin 71939-50-9 Dihydroartemisinin is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua with anti-cancer and antimalarial activities.
CSN25554 Chloroquine Sulphate 132-73-0 Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.
CSN25650 Chloroquine 54-05-7 Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.
CSN26426 Brazilin 474-07-7 Brazilin, a red dye precursor obtained from the heartwood of several species of tropical hardwoods, inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities.
CSN22545 Autophinib 1644443-47-9 Autophinib is an ATP-competitive inhibitor of the VPS34 with IC50 of 19 nM, also inhibitor of starvation- and Rapamycin-induced autophagy with IC50 of 40 and 90 nM respectively.
CSN32731 Autogramin-2 2375541-45-8 Autogramin-2 is a new class of autophagy inhibitor with IC50 value of 0.27 ± 0.09 µM (measured by amino acid starvation induced autophagy) and 0.14 ± 0.08 µM (measured by Rapamycin induced autophagy) through targeting GRAMD1A.
CSN23318 3BDO 890405-51-3 3BDO is a new mTOR activator which can also inhibit autophagy.
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