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Autophagy

Autophagy

货号 产品名 CAS号 信息
CSN12203 Vinorelbine Ditartrate 125317-39-7 Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals.
CSN25238 UBCS039   358721-70-7 UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes.
CSN25367 Typhaneoside 104472-68-6 Typhaneoside, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function.
CSN11588 Sulfacetamide Sodium 127-56-0 Sulfacetamide sodium is a sulfonamide antibiotic that is used topically to treat skin infections and orally for urinary tract infections.
CSN16665 STF-62247 315702-99-9 STF-62247 is an autophagy inducer in VHL-deficient renal cell carcinoma cells and shows selective toxicity and growth inhibition for cells with VHL deficiency (VHL-) compared to wild-type (VHL+).
CSN17766 SR-9011 1379686-29-9 SR9011 is an agonist of REV-ERB with IC50 of 790 nM for REV-ERBα and IC50 = 560 nM for REV-ERBβ.
CSN23843 Sofalcone 64506-49-6 Sofalcone is an anti-ulcer chalcone derivative, it could induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
CSN17302 SMER28 307538-42-7 SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of the mTOR pathway.
CSN20231 ROC-325 1859141-26-6 ROC-325 is an inhibitor of autophagy with promising anti-leukemic activity, which diminishes AML cell viability with the IC50 range of 0.7-2.2 μM.
CSN24043 Metformin 657-24-9 Metformin is a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).
CSN16694 Metformin HCl   1115-70-4 Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).
CSN22904 IITZ-01 1807988-47-1 IITZ-01 is an inhibitor of lysosomotropic autophagy. It can enhance autophagosome accumulation and inhibit autophagosomal degradation that finally resulting in the inhibition of autophagy.
CSN11173 Hydroxychloroquine Sulfate 747-36-4 Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9.
CSN25649 Hydroxychloroquine 118-42-3 Hydroxychloroquine is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9.
CSN26154 Fluspirilene 1841-19-6 Fluspirilene is a relatively long-acting injectable depot antipsychotic drug. It also works as autophagy inducer that inhibits the intracellular flux of calcium, thus removing the activation factor of calpain. And the cleavage of Atg5 is eventually prevented by fluspirilene treatment in a time-course study.
CSN25555 EACC 864941-31-1 EACC inhibits autophagic flux by blocking autophagosome-lysosome fusion. It does not have any effect on lysosomal properties or on endocytosis-mediated degradation of EGF receptor. It affects the translocation of SNAREs Stx17 and SNAP29 on autophagosomes without impeding the completion of autophagosomes.
CSN25554 Chloroquine Sulphate 132-73-0 Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.
CSN25650 Chloroquine 54-05-7 Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.
CSN22545 Autophinib 1644443-47-9 Autophinib is an ATP-competitive inhibitor of the VPS34 with IC50 of 19 nM, also inhibitor of starvation- and Rapamycin-induced autophagy with IC50 of 40 and 90 nM respectively.
CSN23318 3BDO 890405-51-3 3BDO is a new mTOR activator which can also inhibit autophagy.
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