Bcr-Abl | Cytoskeleton|Protein Tyrosine Kinase/RTK|TGF-beta/Smad| CSNpharm

Bcr-Abl

Bcr-Abl
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货号	产品名	CAS号	信息
CSN22517	Target Protein-binding Moiety 8	910297-51-7	PROTAC Bcr-Abl-binding moiety 1 is a Dasatinib-based warhead ligand for conjugation reactions of PROTAC targeting on Bcr-Abl.
CSN12740	Lyn-IN-1	887650-05-7	Lyn-IN-1 is a potent and selective dual Bcr-Abl/Lyn inhibitor with potential antineoplastic activity, it is an orally bioavailable 2-phenylaminopyrimidine derivative.
CSN12398	GNF-5	778277-15-9	GNF-5 is a selective non-ATP competitive inhibitor of Bcr-Abl with IC50 of 220 nM, it's an analogue of GNF-2 with improved pharmacokinetic properties.
CSN28520	GMB-805	2489876-41-5	GMB-805 is a novel potent BCR-Abl PROTAC, inducing degradation and demonstrating in vivo activity.
CSN25549	GMB-475	2490599-18-1	GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 reduced viability and increased apoptosis in primary CML CD34+ cells, with no effect on healthy CD34+ cells at identical concentrations.
CSN16096	DPH	484049-04-9	DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.
CSN21248	BCR-ABL-IN-1	188260-50-6	BCR-ABL-IN-1 is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia.