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Bcr-Abl
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN15826 | ZM 306416 | 690206-97-4 | ZM-306416 is an inhibitor of VEGFR (Flk-1 or KDR) and Flt with IC50 of 100 nM and 2 μM. It also shows inhibition activity against Src and Abl with IC50 values of 0.33μM and 1.3μM, respectively. |
| CSN28459 | SIAIS178 | 2376047-73-1 | SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity. |
| CSN18591 | Radotinib | 926037-48-1 | Radotinib is a selective BCR-ABL1 inhibitor with IC50 of 34 nM, also inhibits platelet-derived growth factor receptor (PDGFR), is used to treat cancers and Chronic Myeloid Leukemia. |
| CSN22517 | N-Deshydroxyethyl Dasatinib | 910297-51-7 | PROTAC Bcr-Abl-binding moiety 1 is a Dasatinib-based warhead ligand for conjugation reactions of PROTAC targeting on Bcr-Abl. |
| CSN23049 | PPY-A | 875634-01-8 | PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases with IC50s of 9 and 20 nM, respectively. |
| CSN21067 | Ponatinib hydrochloride | 1114544-31-8 | Ponatinib is a multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src respectively. |
| CSN32501 | Vamotinib | 1416241-23-0 | PF-114 is a Bcr-Abl1 inhbitor. |
| CSN16663 | NVP-BHG712 | 940310-85-0 | NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition and also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively. |
| CSN17632 | Olverembatinib | 1257628-77-5 | GZD824 is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl (WT) and Bcr-Abl (T315I) with IC50 of 0.34 and 0.68 nM, respectively. |
| CSN18803 | Olverembatinib dimesylate | 1421783-64-3 | GZD824 dimesylate is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl (WT) and Bcr-Abl (T315I) with IC50 of 0.34 nM and 0.68 nM, respectively. |
| CSN28520 | N-(4-(Chlorodifluoromethoxy)phenyl)-6-((2-(2-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)ethyl)amino)-5-(1H-pyrazol-3-yl)nicotinamide | 2489876-41-5 | GMB-805 is a novel potent BCR-Abl PROTAC, inducing degradation and demonstrating in vivo activity. |
| CSN25549 | GMB-475 | 2490599-18-1 | GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 reduced viability and increased apoptosis in primary CML CD34+ cells, with no effect on healthy CD34+ cells at identical concentrations. |
| CSN18538 | Flumatinib | 895519-90-1 | Flumatinib is a multi-kinase inhibitor with IC50 Values of 1.2 nM, 307.6 nM and 2662 nM for c-Abl, PDGFRβ and c-Kit respectively. |
| CSN16497 | Dasatinib | 302962-49-8 | Dasatinib is a potent and dual Abl/ Src inhibitor IC50 of < 1 nM/0.8 nM respectively and also inhibits c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM. |
| CSN18475 | Dasatinib hydrochloride | 854001-07-3 | Dasatinib HCl is a potent and dual Abl/ Src inhibitor IC50 of < 1 nM/0.8 nM respectively and also inhibits c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM. |
| CSN28518 | SNIPER(ABL)-039 | 2222354-29-0 | DAS-IAP is a novel PROTAC targeting drug-resistant BCR-ABL. |
| CSN12423 | Danusertib | 827318-97-8 | Danusertib is a pyrrolo-pyrazole and small molecule Aurora kinases inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively. It is modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. |
| CSN27382 | CZC-8004 | 916603-07-1 | CZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase. |
| CSN15883 | Agerafenib | 1188910-76-0 | CEP-32496 is an inhibitor of BRAF V600E (IC50 = 14 nM), WT (IC50 = 34 nM) and c-Raf (IC50 = 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2. |
| CSN26601 | BCR-ABL-IN-3 | 2240191-12-0 | BCR-ABL-IN-3 is a potent and irreversible Bcr-Abl inhibitor with an IC50 of ≤100 nM for Ba/F3Bcr-AblT3151. BCR-ABL-IN-3 has anti-cancer activity[1]. |
| CSN21248 | BCR-ABL-IN-1 | 188260-50-6 | BCR-ABL-IN-1 is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia. |
| CSN19269 | Bafetinib | 859212-16-1 | Bafetinib is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit. |
| CSN18365 | AST 487 | 630124-46-8 | AST-487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM. AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM. |
| CSN18872 | Asciminib | 1492952-76-7 | Asciminib is a potent and selective allosteric Bcr-Abl inhibitor and inhibits Ba/F3 cells grown with an IC50 of 0.25 nM. |
| CSN25318 | (4-((2-Cyclopentyl-9-(3-hydroxyphenethyl)-9H-purin-6-yl)amino)phenyl)dipropylphosphine oxide | 834894-21-2 | AP23848 is a potent Bcr-Abl inhibitor. In a murine model, AP23848 inhibited activation-loop mutant Kit phosphorylation and tumor growth. |
| CSN29430 | Vodobatinib | 1388803-90-4 | |
| CSN38604 | PD180970 | 287204-45-9 | |
| CSN40473 | Herbimycin A | 70563-58-5 | |
| CSN38802 | DB07107 | 552332-71-5 | |
| CSN35035 | NVP-BHG712 isomer | 2245892-85-5 | |
| CSN35548 | Dasatinib metabolite M6 | 910297-53-9 | |
| CSN35559 | CT-721 | 1388710-60-8 | |
| CSN42896 | AZD0424 | 692054-06-1 | |
| CSN66519 | Adaphostin | 241127-58-2 | |
| CSN67518 | BCR-ABL1-IN-1 | 1488090-21-6 | |
| CSN68746 | PD166326 | 185039-91-2 | |
| CSN79676 | CHMFL-ABL-053 | 1808287-83-3 | |
| CSN78338 | c-ABL-IN-2 | 2574593-54-5 | |
| CSN78326 | c-ABL-IN-3 | 2626934-64-1 | |
| CSN78854 | c-ABL-IN-1 | 2304918-82-7 | |
| CSN80455 | 4-(N-(4-cyclohexylbenzyl)-2-((N-((perfluorophenyl)methyl)-4-(trifluoromethyl)phenyl)sulfonamido)acetamido)-2-hydroxybenzoic acid | 1803281-30-2 | |
| CSN79422 | c-ABL-IN-4 | 2626934-68-5 | |
| CSN83349 | Bosutinib hydrate | 918639-08-4 | |
| CSN84818 | Asciminib hydrochloride | 2119669-71-3 | |
| CSN107180 | (E)-(2-Methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)-L-alanine | 592543-24-3 | |
| CSN105890 | Tyrphostin AG 1112 | 153150-84-6 | |
| CSN107696 | 4-((3,5-Dichloro-4-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile | 1391063-17-4 | |
| CSN107050 | ONO 12380 | 936915-58-1 | |
| CSN51530 | 9-Isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(pyridin-3-yl)-9H-purine-2,8-diamine | 1350544-93-2 |
