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β-catenin
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17476 | WAY-262611 | 1123231-07-1 | WAY-262611 is an agonist of β-Catenin and can increase bone formation rate with EC50 of 0.63 μM. |
| CSN19412 | Triptonide | 38647-11-9 | Triptonide, a natural product isolated and purified from the herb of Tripterygium wilfordii Hook.f. with antileukemic, antitumor, anti-inflammatory activities, is effective in the treatment of autoimmune diseases. Triptonide can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. |
| CSN11885 | Salinomycin | 53003-10-4 | Salinomycin, an antibiotic potassium ionophore, is an anti-coccidial drug and an autophagy modulator. It is also an inhibitor of Wnt/β-catenin signaling. |
| CSN11650 | Pamidronic Acid | 40391-99-9 | Pamidronic Acid is a an amino- bisphosphonate used to prevent bone loss and treat osteoporosis. |
| CSN33101 | NRX-103094 | N/A | NRX-103094, a molecular glue, is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM. |
| CSN20582 | KY1220 | 292168-79-7 | KY1220 inhibits Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 cells and it can destabilize both β-catenin and Ras. |
| CSN22363 | C-82 | 1422253-37-9 | C-82 is an active metabolite of PRI-724 which selectively inhibits the CBP/β-catenin interaction. |
| CSN20163 | BC2059 | 1227637-23-1 | beta-Catenin inhibitor BC2059 is efficacious as monotherapy or in combination with proteasome inhibitor bortezomib in multiple myeloma. |
