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c-Met/HGFR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12917 | Tivantinib | 905854-02-6 | Tivantinib is an non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM with little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. |
| CSN19153 | S49076 | 1265965-22-7 | S49076 is a potent inhibitor of MET, AXL/MER, and FGFRs. |
| CSN12934 | PHA-665752 | 477575-56-7 | PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM. |
| CSN23572 | Norcantharidin | 29745-04-8 | Norcantharidin is a potential antitumor agent. |
| CSN23685 | Ningetinib Tosylate | 1394820-77-9 | Ningetinib tosylate is an inhibitor of tyrosine kinase inhibitor (TKI) and the IC50 for c-Met, VEGFR2 and Axl are 6.7 nM, 1.9 nM and <1.0 nM respectively. |
| CSN17658 | MK-8033 HCl | 1283000-43-0 | MK8033 HCl is a specific dual ATP competitive c-Met/Ron inhibitor (IC50=1 nM Wt c-Met) under investigation as a treatment for cancer. |
| CSN19988 | Herbacetin | 527-95-7 | Herbacetin, a natural product isolated and purified from the herbs of Equisetum hyemale L. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro. |
| CSN12685 | Foretinib | 849217-64-7 | Foretinib is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Foretinib is less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and with little activity to FGFR1 and EGFR. |
| CSN24316 | Dihexa acetate | 2453297-24-8 | Dihexa is a blood-brain barrier-permeable angiotensin IV analog which exhibits high affinity to HGF with Kd value of 65pM and induces c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. |
| CSN25585 | RON-IN-1 | 913376-84-8 | c-Met/RON Dual Kinase Inhibitor is a potent inhibitor against the kinase activities of HGF receptor c-Met and MSP (Macrophage Stimulating Protein) receptor RON with IC50 of 4 and 9 nM, respectively, and it is reported to inhibit NIH3T3 TRP-Met and U-87 tumor growth in mice in vivo in a dose-dependent manner. |
| CSN25296 | BAY 474 | 1033767-86-0 | BAY 474 is a tyrosine-protein kinase c-Met inhibitor and a structural genomics consortium (SGC) epigenetics probe. |