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CaMK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN26523 | Verosudil | 1414854-42-4 | Verosudil, also known as AR-12286, is a potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfoliation syndrome) and OHT (ocular hypertension) or XFG (exfoliative glaucoma). This drug may represent an additional therapeutic paradigm for the treatment of XFG. |
| CSN19242 | STO-609 | 52029-86-4 | STO-609 is a specific inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK) that inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/mL, respectively, and also inhibits their autophosphorylation activities. |
| CSN20500 | STO-609 acetate | 1173022-21-3 | STO-609 acetate is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ (Ki = 80 and 15 ng/mL, respectively). |
| CSN20312 | Rimacalib | 215174-50-8 | SMP-114 is a CaMKII inhibitor with oral bioavailability and mediates the reduction SR Ca(2+) leak and arrhythmogenic cellular correlates. |
| CSN16664 | NH125 | 278603-08-0 | NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, also a potent histidine kinase inhibitor. |
| CSN21729 | Melittin | 20449-79-0 | Melittin can bind calmodulin in a Ca2+-dependent manner and inhibit Na+-K+-ATPase that plays a vital role in Epilepsy treatment. |
| CSN18794 | KN-93 Phosphate | 1188890-41-6 | KN-93 Phosphate, a potent Ca2+/calmodulin-dependent protein kinase II (CaMKII) selective inhibitor with Ki of 370 nM, is the water soluble version of KN-93. |
| CSN19063 | KN-93 phosphate | 1913269-12-1 | KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). |
| CSN11255 | KN-93 | 139298-40-1 | KN-93 is a potent Ca2+/calmodulin-dependent protein kinase II (CaMKII) selective inhibitor with Ki of 370 nM. |
| CSN16900 | KN-93 hydrochloride | 1956426-56-4 | KN-93 HCl is a membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with Ki of 370 nM. |
| CSN16913 | KN-92 phosphate | 1135280-28-2 | KN-92 phosphate is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). |
| CSN19064 | KN-92 | 176708-42-2 | KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). |
| CSN17850 | KN-92 hydrochloride | 1431698-47-3 | KN-92 HCl a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). |
| CSN24178 | Cabamiquine | 1469439-69-7 | DDD107498 is a multiple-stage antimalarial agent targeting on eEF2. |
| CSN22017 | CV-159 | 86384-98-7 | CV-159 is a unique dihydropyridine Ca2+ antagonist with an anti-calmodulin (CaM) action and shows antiinflammatory activities. |
| CSN22547 | CRT0066101 dihydrochloride | 1883545-60-5 | CRT0066101 reduces BrdU incorporation, increases apoptosis, blocks neurotensin (NT)-induced PKD1/2 activation, reduces NT-induced PKD-mediated Hsp27 phosphorylation, attenuates PKD1-mediated NF-κB activation, and abrogates expression of NF-κB-dependent-dependent proliferative and pro-survival proteins. |
| CSN22740 | Camstatin | 1002295-95-5 | Camstatin is a calmodulin antagonist. |
| CSN17563 | CaMKII-IN-1 | 1208123-85-6 | CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM, displaying significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC. |
| CSN21543 | Calmodulin-Dependent Protein Kinase II (290-309) | 115044-69-4 | Calmodulin-dependent protein kinase II (290-309) is a potent inhibitor of Ca2+/calmodulin-dependent protein kinase II. |
| CSN23191 | N-(6-Aminohexyl)naphthalene-1-sulfonamide hydrochloride | 61714-25-8 | Calmodulin antagonist |
| CSN23190 | W-13 HCl | 88519-57-7 | Calmodulin antagonist |
| CSN23192 | W-7 isomer hydrochloride | 69762-85-2 | Calmodulin antagonist |
| CSN22737 | Calmidazolium chloride | 57265-65-3 | Calmidazolium Chloride is a calmodulin antagonist. |
| CSN10417 | Berbamine | 478-61-5 | Berbamine, a natural product isolated and purified from the roots of Cocculus orbiculatus (L.) DC., has high binding affinity toward the (GGA)8 G-quadruplex, and is a promising agent to suppress liver cancer growth by targeting CAMKII. |
| CSN10418 | Berbamine dihydrochloride | 6078-17-7 | Berbamine 2HCl, a natural product isolated and purified from the roots of Cocculus orbiculatus (L.) DC., has high binding affinity toward the (GGA)8 G-quadruplex, and is a promising agent to suppress liver cancer growth by targeting CAMKII. |
| CSN22694 | Autocamtide-2-related inhibitory peptide, myristoylated | 201422-04-0 | Autocamtide-2-related Inhibitory Peptide, myristoylated is a CaM kinase II inhibitor that enhances cell permeable derivative of Autocamtide-2-related inhibitory peptide. |
| CSN22693 | Autocamtide-2-related inhibitory peptide | 167114-91-2 | Autocamtide-2-related Inhibitory Peptide is a selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor with IC50 of 40 nM. |
| CSN20471 | Arcyriaflavin A | 118458-54-1 | Arcyriaflavin A is a potent inhibitor of cdk4/cyclin D1 (IC50 = 59 nM) and CaM kinase II (IC50 = 25 nM) but displays selectivity over several other kinases in vitro (IC50 values for inhibition of PKA and PKC are > 2 and > 100 μM respectively). It can also inhibit human cytomegalovirus (HCMV) replication in vitro (IC50 = 200 nM). |
| CSN22660 | A-7 hydrochloride | 79127-24-5 | A-7 HCl is a potent calmodulin antagonist. |
| CSN22750 | Zaldaride maleate | 109826-27-9 |
