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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN22566 | Vorasidenib | 1644545-52-7 | Vorasidenib is an isocitrate dehydrogenase (IDH) inhibitor. |
| CSN22468 | MOZ-IN-2 | 2055397-88-9 | MOZ-IN-2 is an inhibitor of protein MOZ, a member of histone acetyltransferases, with an IC50 of 125 μM. |
| CSN22526 | Tucidinostat | 1616493-44-7 | Tucidinostat is an inhibitor of HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor with IC50s of 95, 160, 67 and 78 nM, espectively. |
| CSN22506 | SJ000291942 | 425613-09-8 | SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules. |
| CSN22425 | GSTO-IN-2 | 1202710-57-3 | GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1. |
| CSN22449 | LLY-283 | 2040291-27-6 | LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity. |
| CSN22427 | VH032-PEG5-C6-Cl | 1799506-06-1 | HaloPROTAC 2 is a PROTAC block consist of VH032 and a linker with chlorine functional group for conjugation reactions. |
| CSN22399 | ETC-206 | 1464151-33-4 | ETC-206 is a selective MNK1 and MNK2 inhibitor with IC50s of 64 nM and 86 nM, respectively. |
| CSN22492 | Boc-C1-PEG2-C4-Cl | 1835705-53-7 | PROTAC Linker 1 is a linker used to link the warhead and the E3 ligase ligand. |
| CSN22505 | SHIN1 | 2146095-85-2 | SHIN1 is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. |
| CSN22467 | WM-1119 | 2055397-28-7 | MOZ-IN-1 is an inhibitor of MOZ which is a member of histone acetyltransferases with IC50 of 0.051 μM. |
| CSN22532 | Vecabrutinib | 1510829-06-7 | Vecabrutinib is a potent BTK inhibitor, with IC50s of 4.6 nM and 1.1 nM for WT BTK and C481S BTK, respectively, and also inhibits ITK activity (IC50, 24 nM). |
| CSN22485 | PF-06459988 | 1428774-45-1 | PF-06459988 is an irreversible inhibitor of T790M-Containing EGFR Mutants. |
| CSN22428 | Hesperin | 4430-35-7 | Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an Nrf2 activator. |
| CSN22507 | SLV-2436 | 2095704-43-9 | SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively. |
| CSN22412 | Gigantol | 67884-30-4 | Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. |
| CSN22456 | M443 | 1820684-31-8 | M443 is an irreversible and specific inhibitor of MRK, with an IC50<125 nM. |
| CSN22432 | TNP | 519178-28-0 | IP3K Inhibitor is a IP3K inhibitor with an IC50 of 10.2 μM. |
| CSN22436 | JNJ-38877618 | 943540-74-7 | JNJ-38877618 is a potent, highly selective, orally bioavailable Met kinase inhibitor with IC50s of 2 and 3 nM for wild type and mutant Met, respectively. |
| CSN22508 | SM 16 | 614749-78-9 | SM 16 is an an ATP-competitive ALK5/ALK4 inhibitor with IC50 value between 160 and 620 nM for inhibition of TGF-β1-induced Smad2/3 phosphorylation in cell study. |
| CSN22385 | DDR-TRK-1 | 1934246-19-1 | DDR1-IN-3 is a selective Discoidin Domain Receptor 1 (DDR1) inhibitor, with an IC50 value of 9.4 nM. |
| CSN22386 | Dihydromunduletone | 674786-20-0 | Dihydromunduletone is a selective adhesion G protein–coupled receptor antagonist (aGPR) with an IC50 of ~21 μM. |
| CSN22378 | c-Met-IN-2 | 1635406-73-3 | c-Met-IN-2 is a potent, selective and orally available c-Met inhibitor, with an IC50 of 0.6 nM, with antitumor activity. |
| CSN22426 | GW6471 | 880635-03-0 | GW 6471 is a potent PPARα antagonist. |
| CSN22392 | EGFR-IN-2 | 1643497-70-4 | EGFR-IN-2 is a a noncovalent, irreversible, mutant-selective second generation EGFR inhibitor. |
| CSN22379 | CDK12-IN-3 | 2220184-50-7 | CMPD 7 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay. |
| CSN22368 | CDK8-IN-4 | 1613638-82-6 | CDK8-IN-4 is an inhibitor of CDK8 extracted from patent WO2014090692A1, compound example 16, with an IC50 of 0.2 nM. |
| CSN22430 | Indotecan | 915303-09-2 | Indotecan is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. |
| CSN22406 | FT827 | 1959537-86-0 | FT827 is a selective and covalent ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 52 nM. |
| CSN22460 | MAT2A inhibitor 1 | 2201057-10-3 | MAT2A inhibitor is a methionine adenosyltransferase 2A (MATA2) inhibitor. |
| CSN22395 | EPAC 5376753 | 302826-61-5 | EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells. |
| CSN22484 | 2-Keto Crizotinib | 1415558-82-5 | PF-06260182 is a lactam metabolite of crizotinib. |
| CSN22451 | LY 222306 | 154446-98-7 | LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM. |
| CSN22462 | Mcl1-IN-4 | 1580484-04-3 | Mcl1-IN-4 is an inhibitor of Mcl1 with an IC50 of 0.2 μM. |
| CSN22441 | KO-947 | 1695533-89-1 | KO-947 is a potent and selective inhibitor of ERK1/2 kinases with potential clinical utility in MAPK pathway dysregulated tumors. |
| CSN22521 | TNF-α-IN-1 | 444287-49-4 | TNF-α-IN-1 is a TNF-α inhibitor extracted from patent US20030096841A1, compound example I-7. |
| CSN22453 | LY309887 | 127228-54-0 | LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity. |
| CSN22422 | GSK 4027 | 2079896-25-4 | GSK 4027 is a chemical probe for the PCAF/GCN5 bromodomain with an pIC50 of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. |
| CSN22480 | Parsaclisib | 1426698-88-5 | Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. |
| CSN22466 | ML132 | 1230628-71-3 | ML132 is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM. |
| CSN22528 | UAA crosslinker 1 | 1167421-25-1 | UAA crosslinker 1 act as substrates for pylRS/tRNA pair that enable its incorporation into a target protein. |
| CSN22515 | SLF-amido-C2-COOH | 1092369-24-8 | PROTAC FKBP12-binding moiety 1 is a synthetic ligand for FKBP, used as a warhead ligand for conjugation reactions of PROTAC targeting on FKBP12. |
| CSN22516 | PROTAC BRD9-binding moiety 1 | 2097512-23-5 | PROTAC BRD9-binding moiety 1 is a I-BRD9-based warhead ligand for conjugation reactions of PROTAC targeting on BRD9. |
| CSN22473 | Ebopiprant | 2005486-31-5 | OBE022 is an oral and selective prostaglandin F2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively. |
| CSN22517 | N-Deshydroxyethyl Dasatinib | 910297-51-7 | PROTAC Bcr-Abl-binding moiety 1 is a Dasatinib-based warhead ligand for conjugation reactions of PROTAC targeting on Bcr-Abl. |
| CSN23328 | GDC-0575 | 1196541-47-5 | GDC-0575 is a potent and selective CHK1 inhibitor. |
| CSN23752 | Elemicin | 487-11-6 | Elemicin is a phenylpropene with anticancer and antifungal activities, it exhibits anticholinergic-like effects in humans. |
| CSN23772 | Thalidomide-O-amido-C8-NH2 | 1950635-15-0 | Thalidomide-O-amido-C8-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions. |
| CSN22491 | PRI-724 | 1422253-38-0 | PRI-724 is a selective inhibitor of the CBP/β-catenin interaction. |
| CSN24156 | E260 | 1241537-79-0 | E260 is an inhibitor of the Fer/FerT kinase with Kd of 0.85 μM, selectively evokes metabolic stress and necrotic death in cancer cells. |
