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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN20443 | CYM-5541 | 945128-26-7 | CYM-5541 is an allosteric agonist of S1P3 with EC50 of 72 nM - 132 nM. |
| CSN20530 | Eniporide | 176644-21-6 | Eniporide is an inhibitor of Na+/H+ exchange that prevents ischemic Na+ overload. |
| CSN20539 | Lanifibranor | 927961-18-0 | IVA-337 is a agonist of peroxisome proliferator-activated receptors (PPAR) which is widely used in the study of lung fibrosis and pulmonary hypertension. |
| CSN20559 | Cariporide | 159138-80-4 | Cariporide is a selective inhibitor of Na+/H+ exchanger isoform 1 (NHE1) with IC50 value of 0.05 μM with cardioprotective and antiarrhythmic effects. |
| CSN21304 | SL910102 | 144756-71-8 | SL910102 is a nonpeptide angiotensin AT1 receptor antagonist. |
| CSN21291 | ML171 | 6631-94-3 | ML171 is a novel and selective NOX1 inhibitor with IC50 value of 0.25 μM for blocking NOX1-dependent ROS generation in a HEK293-NOX1 recombinant cell system. |
| CSN21155 | L-NMMA acetate | 53308-83-1 | L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively. |
| CSN21293 | Caldaret | 133804-44-1 | Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition. |
| CSN21151 | VAS2870 | 722456-31-7 | VAS2870 is a specific and effect NADPH oxidase inhibitor with IC50 value of 10.6 µM against NOX activity in human neutrophil lysates. |
| CSN21258 | Tecadenoson | 204512-90-3 | Tecadenoson is a selective A1 adenosine receptor agonist. |
| CSN21296 | AGN 192836 | 171102-29-7 | AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively. |
| CSN21247 | (±)-WS75624B | 188048-45-5 | (±)-WS75624B is an endothelin converting enzyme (ECE) inhibitor with an IC50 of 0.03 μg/mL. |
| CSN21177 | Mitochonic acid 5 | 1354707-41-7 | Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage. Mitochonic acid 5 modulates mitochondrial ATP synthesis. |
| CSN21324 | Naminidil | 220641-11-2 | Naminidil is a cyanoguanidine KATP opener. |
| CSN21301 | FR183998 free base | 239440-20-1 | FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively. |
| CSN21162 | BPTU | 870544-59-5 | BPTU allosteric antagonist of P2Y1 wtih IC50 of 0.06-0.3 μM with antithrombotic effect and reduces platelet aggregation. |
| CSN22500 | RP-64477 | 135239-65-5 | RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). |
| CSN22508 | SM 16 | 614749-78-9 | SM 16 is an an ATP-competitive ALK5/ALK4 inhibitor with IC50 value between 160 and 620 nM for inhibition of TGF-β1-induced Smad2/3 phosphorylation in cell study. |
| CSN20537 | Mavacamten | 1642288-47-8 | MYK-461 is a myosin inhibitor potentially for the treatment of hypertrophic cardiomyopathy, and can reduce contractility by decreasing the adenosine triphosphatase activity of the cardiac myosin heavy chain. |
| CSN20632 | Octreotide | 83150-76-9 | Octreotide is an analog of somatostatin that binds to the somatostatin receptor 2/3/5. It can increase Gi activity and reduce the production of intracellular cAMP. |
| CSN22112 | Lodelaben | 111149-90-7 | Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively. |
| CSN20586 | SR 49059 | 150375-75-0 | SR49059 is a potent and selective non-peptide vasopressin V1A receptor antagonist which is devoid of agonist activity. SR49059 displays high affinity and efficacy at both rat (Ki = 1.6 nM) and human (Ki = 1.1 - 6.3 nM) V1A receptors and potently antagonizes arginine vasopressin-induced effects in vitro (IC50 = 3.7 nM for inhibition of human platelet aggregation) and is orally active in vivo. |
| CSN22136 | Edg-2 Receptor Inhibitor 1 | 1195941-38-8 | Edg-2 receptor inhibitor 1 is an Edg-2 receptor inhibitor extracted from patent WO2009135590A1, Compound Example 14, has an IC50 of <0.1 μM. |
| CSN22113 | Ifetroban | 143443-90-7 | Ifetroban is a long-acting thromboxane A2 receptor antagonist, with antiplatelet activity. |
| CSN22110 | Bepridil hydrochloride | 68099-86-5 | Bepridil HCl is a calcium channel blocker, with antianginal activity. |
| CSN22111 | Carbacyclin | 69552-46-1 | Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation. |
| CSN22530 | Ubrogepant | 1374248-77-7 | Ubrogepant is an oral calcitonin gene-related peptide receptor (CGRP) antagonist in development for acute treatment of migraine. |
| CSN22159 | ICI 153110 | 87164-90-7 | ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure. |
| CSN21356 | S107 hydrochloride | 1357476-46-0 | S107 HCl is a RyR-selective 1,4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels. |
| CSN22181 | OM-189 | 55381-18-5 | OM-189 is a selective synthetic thrombin inhibitor. |
| CSN22174 | CE-245677 | 717899-97-3 | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM. |
| CSN21359 | SQ-31765 | 138383-07-0 | SQ-31765 is a benzazepine calcium channel blocker. |
| CSN21398 | PKG drug G1 | 374703-78-3 | PKG Drug G1 targets C42 of PKG Iα. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism. |
| CSN22178 | PRX933 hydrochloride | 639029-42-8 | PRX933 HCl is a 5-HT2c receptor agonist. |
| CSN21408 | Delcasertib | 949100-39-4 | KAI-9803 is a potent and selective δ protein kinase C (δ PKC) inhibitor. |
| CSN22338 | AE-3763 | 291778-77-3 | AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM. |
| CSN22373 | CGRP antagonist 1 | 1123757-49-2 | CGRP antagonist 1 is a highly potent CGRP receptor antagonist with a Ki and IC50 of 35 and 57 nM, respectively. |
| CSN22395 | EPAC 5376753 | 302826-61-5 | EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells. |
| CSN22463 | TA-316 | 1429321-13-0 | Megakaryocytes/platelets inducing agent is an inducing agent for megakaryocytes and/or platelets from pluripotent stem cells, the inducing agent being useful in treating diseases involving thrombopenia. |
| CSN22511 | Solenopsin | 137038-57-4 | Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM . |
| CSN22490 | Pparδ agonist 1 | 1902161-12-9 | Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases. |
| CSN22444 | L-765314 | 189349-50-6 | L-765314 is a potent and selective α1b adrenergic receptor antagonist with Kis of 5.4±0.6 nM and 2.0±0.66 nM for rat and human α1b adrenergic receptor, respectively. |
| CSN22536 | ZD-0892 | 171964-73-1 | ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively. |
