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货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN19215 | Cyclo(RGDyK) trifluoroacetate | 250612-42-1 | Cyclo(RGDyK) is a highly potent and selective inhibitor for the αvβ3 integrin with a IC50 of 0.94 nM. |
CSN19307 | Tetrahydrozoline HCl | 522-48-5 | Tetrahydrozoline HCl is an imidazole-derived alpha-adrenergic receptor agonist which can result vasoconstriction and decreased nasal and ophthalmic congestion. |
CSN19474 | Sarpogrelate HCl | 135159-51-2 | Sarpogrelate HCl is an antagonist of both 5HT2A and 5-HT2B receptors, which can block serotonin-induced platelet aggregation and treat diabetes mellitus, Buerger's disease, Raynaud's disease, coronary artery disease, angina pectoris and atherosclerosis. |
CSN20344 | 1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea hydrochloride | 1333327-56-2 | TRC051384 is an inducer of heat shock protein Hsp70. it reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke and activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity. |
CSN20179 | Isopimaric acid | 5835-26-7 | Isopimaric acid, a natural product isolated and purifed from the herbs of Daemonorops draco Blume, potently opens large conductance Ca-activated K+ channels and also possibly has an antagonistic interaction with reserpine which may render the antibiotics inactive. |
CSN19095 | PF-1355 | 1435467-38-1 | PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases. |
CSN19097 | NQ301 | 130089-98-4 | NQ301, a selective CD45 inhibitor with an IC50 of 200 nM, is also an antithrombotic agent and inhibits collagen-challenged rabbit platelet aggregation with an IC50 of 10 mg/mL. |
CSN19723 | 4-(1-Hydroxy-2-((1-phenoxypropan-2-yl)amino)propyl)phenol hydrochloride | 579-56-6 | Isoxsuprine is a modulator of β2 adrenoreceptor and has agonist or antagonist effects. |
CSN19708 | GSK2193874 | 1336960-13-4 | GSK2193874 is a selective transient receptor potential vanilloid 4 (TRPV4) blocker with IC50 value of 0.04 μM. |
CSN20029 | Sodium 4-(2-Hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate | 88475-69-8 | Esuberaprost is a potential substance for treating pulmonary arterial hypertension (PAH). |
CSN19250 | 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine hydrochloride | 1313883-00-9 | ARQ 092 is a pan-Akt inhibitor with IC50 values of 5nM, 4.5nM and 16nM for Akt1, Akt2 and Akt3, respectively, through blocking membrane translocation of inactive AKT and even dephosphorylating the membrane-associated active form. |
CSN19865 | Blebbistatin | 674289-55-5 | (-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. |
CSN19827 | Ataciguat | 254877-67-3 | Ataciguat is a potent guanylate cyclase activator potentially for the treatment of aortic valve stenosis. |
CSN18971 | ONO-7300243 | 638132-34-0 | ONO-7300243 is a potent LPA1 (Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM. |
CSN19430 | Fendiline HCl | 13636-18-5 | Fendiline HCl is a nonselective calcium channel blocker. |
CSN20345 | TRC051384 | 867164-40-7 | TRC051384 is a inducer of Hsp70. |
CSN18983 | Cinaciguat HCl | 646995-35-9 | Cinaciguat HCl is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets. |
CSN19465 | Pirmenol HCl | 61477-94-9 | Pirmenol HCl inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM. |
CSN19040 | R 80123 | 133718-30-6 | R80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. |
CSN19707 | Vericiguat | 1350653-20-1 | Vericiguat targets soluble guanylate cyclase (sGC) and is used for treating heart failure. |
CSN19122 | PF-06282999 | 1435467-37-0 | PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases. |
CSN18666 | SBC-110736 | 1629166-02-4 | SBC-110736 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9), lowering cholesterol levels in mice. |
CSN19881 | Salvianolic acid C | 115841-09-3 | Salvianolic acid C, a natural product isolated and purified from the root of Salvia miltiorrhiza Bge. with antioxidant effect, exhibits potent XOD inhibitory activity with an IC(50) of 9.07 μM, and enhances the inhibitory effects on sEH might be efficient ways to improve its cardiovascular protective and anti-inflammatory effects. |
CSN20173 | Cp-154526 | 157286-86-7 | CP-154526 is a selective, non-peptide CRF1 receptor antagonist (Ki values are 2.7 and > 10000 nM for CRF1 and CRF2 receptors respectively). CP-154526 blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF. |
CSN19108 | YS-49 monohydrate | N/A | YS 49 inhibits Ang II-stimulated proliferation of VSMCs via induction of HO-1. |
CSN52455 | 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one methanesulfonate | 1308285-21-3 | |
CSN19227 | PRX-08066 maleate | 866206-55-5 | PRX-08066 maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. |
CSN20421 | PDE5 Inhibitor C2 | 2109805-65-2 | PDE5 inhibitor C2, a chromeno[2,3-c]pyrrol-9(2H)-one derivate, is a selective and orally bioavailable phosphodiesterase 5 inhibitor for the treatment of pulmonary arterial hypertension. |
CSN19760 | Clazosentan | 180384-56-9 | Clazosentan is a potent endothelin A antagonist, improves cerebral blood flow and behavior after traumatic brain injury. |
CSN20026 | Esuberaprost | 94132-88-4 | Esuberaprost is a potential substance for treating pulmonary arterial hypertension (PAH). |
CSN19691 | BMS-919373 | 1272353-82-8 | IKur inhibitor C25 is a selective IKur inhibitor for the potential treatment of atrial fibrillation. |
CSN20190 | MRS2395 | 491611-55-3 | MRS2395 is an antagonist for the P2Y12 purinoceptor, which causes platelet aggregation in rats via ADP induction. |
CSN20191 | PSB-0739 | 1052087-90-7 | PSB-0739 is an extremely potent and selective competitive P2Y12 receptor antagonist (pA2 of 9.8). |
CSN20192 | AR-C66096 tetrasodium | 145782-74-7 | AR-C 66096 tetrasodium is a potent and selective P2Y12 receptor antagonist which blocks ADP-induced inhibition of adenylyl cyclase in vitro (pKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16). |
CSN20376 | CKD-519 | 1402796-27-3 | CKD-519 is a selective and potent cholesteryl ester transfer protein (CETP) inhibitor being developed for the treatment of dyslipidemia to raise high-density lipoprotein cholesterol. |
CSN20277 | ML-290 | 1482500-76-4 | ML290 is a biased allosteric agonist at the relaxin receptor RXFP1 possessing a signalling profile indicative of vasodilator and anti-fibrotic properties. |
CSN20312 | Rimacalib | 215174-50-8 | SMP-114 is a CaMKII inhibitor with oral bioavailability and mediates the reduction SR Ca(2+) leak and arrhythmogenic cellular correlates. |
CSN20251 | L748337 | 244192-94-7 | L-748337 is a competitive β3-adrenoceptor antagonist that displays selectivity over β1 and β2 receptors (Ki values are 4.0, 204 and 390 nM for β3-, β2- and β1-adrenoceptors respectively). Inhibits cAMP accumulation in response to isoproterenol (IC50 = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line. |
CSN20314 | Buloxibutid | 477775-14-7 | AT2R agonist C21 is a small-molecule ATR receptor (AT2R) agonist. |