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CDK

CDK

货号 产品名 CAS号 信息
CSN17512 XL413 1169558-38-6 XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, > 60-fold selectivity against CK2, > 10-fold selectivity against PIM, and > 300-fold selectivity against a panel of over 100 protein kinases.
CSN16423 (S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one xhydrochloride 1169562-71-3 XL413 HCl is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, > 60-fold selectivity against CK2, > 10-fold selectivity against PIM, and > 300-fold selectivity against a panel of over 100 protein kinases.
CSN16984 WHI-P180 211555-08-7 WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 μM, respectively.
CSN16220 THZ1 1604810-83-4 THZ1 is a selective and potent covalent CDK7 inhibitor with IC50 (binding affinity) of 3.2 nM and inhibits Jurkat cell's proliferation with IC50 of 50 nM.
CSN16121 TG003 719277-26-6 TG003 is a potent inhibitor of Clk1/Sty and Clk4 with IC50 of 15-20 nM, less potency on Clk2 (IC50= 200 nM).
CSN16666 (Z)-3-((1H-Imidazol-4-yl)methylene)-5-methoxyindolin-2-one 377090-84-1 SU9516 is a selective and potent CDK2 inhibtor with IC50 of 22 nM, less potent for CDK1/CDK4 (IC50=40/200 nM), and with no inhibition on PKC, EGFR, p38MAPK, etc.
CSN12378 SNS-032 345627-80-7 SNS-032 is a potent inhibitor of cyclin-dependent kinases (CDKs)9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).
CSN16049 SCH900776 891494-63-6 SCH 900776 (MK-8776) is a selective and highly potent CHK1 inhibitor with IC50 value of 3nM, modest to CDK2 and Chk2 with much higher IC50 values of 160nM and 1.5uM, respectively.
CSN11862 (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol 186692-46-6 Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM and shows little effect on CDK4/6.
CSN11862 (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol   186692-46-6 Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM and shows little effect on CDK4/6.
CSN16564 (Z)-5-(Quinolin-6-ylmethylene)-2-((thiophen-2-ylmethyl)amino)thiazol-4(5H)-one 872573-93-8 Ro 3306 is a potent and selective inhibitor of CDK1 with Ki value of 35 nM for CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and > 50-fold relative to CDK4/cyclin D.
CSN16126 R547 741713-40-6 R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.
CSN16119 Purvalanol B 212844-54-7 Purvalanol B is a selective cyclin-dependent kinases (CDKs) inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.
CSN11800 Purvalanol A 212844-53-6 Purvalanol A is a selective inhibitor of cyclin-dependent kinases (CDKs), it potently inhibits cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35 with IC50 values of 4, 70, 35, 850, and 75 nM respectively.
CSN12713 Milciclib 802539-81-7 PHA-848125 is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM, being > 3-fold selective for CDK2 than CDK1, 2, 4, 5, and 7.
CSN17186 PHA-793887 718630-59-2 PHA-793887 is a pan-cdk inhibitor, inhibits cdk1/2/4/5/7/9 with IC50s of 5 - 140 nM.
CSN16230 PHA-767491 845714-00-3 PHA-767491 is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor with IC50 values of 10/34 nM, and also an inhibitor of NRF2.
CSN15827 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxyethanesulfonate 827022-33-3 Palbociclib isethionate is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases.
CSN12418 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 571190-30-2 Palbociclib is a highly specific inhibitor of Cdk4 and Cdk6 with IC50s of 11 nM and16 nM.
CSN15851 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride1 827022-32-2 Palbociclib HCl is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases.
CSN16662 Riviciclib HCl 920113-03-7 P276-00 is a CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively.
CSN17748 Narazaciclib 1357470-29-1 ON123300 is a potent and multi-targeted kinase inhibitor which inhibits CDK4, Ark5, PDGFRβ, FGFR1, RET, and Fyn with IC50 of 3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM and 11nM respectively.
CSN11589 NU2058 161058-83-9 NU2058 is a CDK inhibitor with IC50 of 17 μM and 26 μM for CDK2 and CDK1.
CSN16279 NG 52 212779-48-1 NG 52 is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).
CSN17183 ML167 1285702-20-6 ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, showing > 10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.
CSN23650 ML 315 1440251-53-5 ML 315 HCl is inhibitor of Clk and DYRK kinases with IC50s of 68, 68 and 231 nM for Clk1, Clk4 and Clk2, 282 and 1156 nM for Dyrk1A and Dyrk1B.
CSN17759 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate 1374639-75-4 LEE011 Succinate is an orally available cyclin-dependent kinase (CDK) inhibitor with highly selective for cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, and potential antineoplastic activity.
CSN17760 Ribociclib succinate hydrate 1374639-79-8 LEE011 succinate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
CSN15813 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 1211441-98-3 LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
CSN17570 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride 1211443-80-9 LEE011 HCl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
CSN16940 (3-((6-(2-Methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methanesulfonamide 1073485-20-7 LDC000067 is a highly specific CDK9 inhibitor with IC50 of 32.7 nM for CDK9/cyclin T1.
CSN12858 JNJ-7706621 443797-96-4 JNJ-7706621 is a pan-CDK inhibitor that inhibits CDK1/2 with IC50 of 9/4 nM, also potently inhibits Aurora A/B.
CSN11014 Flavopiridol 146426-40-6 Flavopiridol is a pan CDK inhibitor with IC50 values of 30nM, 40nM, 20-40nM, 60nM, 875nM and 20nM for CDK1, 2, 4, 6, 7, 9, respectively
CSN11015 Flavopiridol HCl 131740-09-5 Flavopiridol HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM.
CSN16417 CVT-313 199986-75-9 CVT-313 is a potent, selective, ATP-competitive and reversible inhibitor of CDK2 with IC50 of 0.5 μM for Cdk2/A and Cdk2/E; 4.2 μM for Cdk1/B; 215 μM for Cdk4/D1.
CSN17780 Cdk9-in-6 1391855-95-0 CDK9-IN-6 is a CDK9 inhibito.
CSN17642 CDK9-IN-2 1263369-28-3 CDK9-IN-2 is a special cyclin-dependent kinase 9 (CDK9) inhibitor with an IC50 of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively.
CSN17815 CDK9-IN-1 1415559-43-1 CDK9-IN-1 is a selective CDK9 inhibitor for the treatment of HIV infection.
CSN17649 CDK-IN-2 1269815-17-9 CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of < 8 nM.
CSN17795 Ca2+ channel agonist 1 1402821-24-2 Ca2+ channel agonist 1 is a N-type Ca2+ channel activity agonist, with EC50 of 14.23 μM, also inhibits cdk2 kinase activity with EC50 of 3.34 μM.
CSN17151 BS-181 HCl 1397219-81-6 BS-181 is a selective CDK7 inhibitor with IC50 of 21 nM.
CSN16513 BS-181 1092443-52-1 BS-181 is a highly selective CDK7 inhibitor with IC50 of 21 nM.
CSN16547 BMS-265246 582315-72-8 BMS-265246 is a potent and selective CDK1/2 inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 and 9 nM respectively.
CSN16208 AT7519 844442-38-2 AT7519 is a pan-CDKs inhibitor with IC50 values of 47, 13, <10nM for CDK2/CyclinA, CDK5/p35 and CDK9/CyclinT, and modest activity against CDK1/CyclinB, CDK3/CyclinE, CDK4/CyclinD1 and CDK6/CyclinD3 with IC50 values of 210, 360, 100 and 170nM, respectively.
CSN16210 AT7519 HCl 902135-91-5 AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM and less potent to CDK3 and little active to CDK7.
CSN15832 AMG 925 1401033-86-0 AMG-925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively, and with IC50 of 19 nM in MOLM-13 cell.
CSN13886 N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate 1231930-82-7 Abemaciclib Methanesulfonate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers.
CSN15805 N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine 1231929-97-7 Abemaciclib is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM respectively, used for the treatment of advanced or metastatic breast cancers.
CSN15942 1-NM-PP1 221244-14-0 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors with IC50 of 28 μM for vSrc and 4.2 nM for v-Src-as1 I338G.
CSN20800 Senexin A 1366002-50-7
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