Complement System | Immunology/Inflammation| CSNpharm

Complement System

Complement System
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货号	产品名	CAS号	信息
CSN25871	SB290157 trifluoroacetate	1140525-25-2	SB 290157 Trifluoroacetate is the trifluoroacetate form of SB 290157. SB 290157 is a competitive and selective C3aR (anaphylatoxin C3a receptor) antagonist. It blocked C3a-induced C3aR internalization in a concentration-dependent manner and C3a-induced Ca(2+) mobilization in RBL-C3aR cells and human neutrophils with IC(50)s of 27.7 and 28 nM, respectively.
CSN21412	PMX 205 Trifluoroacetate	N/A	PMX 205 Trifluoroacetate is a potent complement C5a receptor (C5aR; CD88) antagonist.
CSN51353	JR14a	2411440-41-8	JR14a is a novel potent and selective antagonist of human Complement C3a receptor.
CSN25566	Danicopan	1903768-17-1	Danicopan is selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. It has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
CSN18113	BCX 1470 methanesulfonate	217099-44-0	BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.
CSN18112	BCX 1470	217099-43-9	BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.