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Coumarins

Coumarins

货号 产品名 CAS号 信息
CSN14098 Xanthoxyletin 84-99-1 Xanthoxyletin, a natural product isolated and purified from the bark of Zanthoxylum elephantiasis.
CSN15315 Triumbelletin 131559-54-1 Triumbelletin is a natural product isolated and purified from the herbs of Wikstroemia indica.
CSN14230 trans-Methylkhellactone 23733-92-8 trans-Methylkhellactone is a natural product isolated and purified from plants.
CSN14229 trans-Khellactone 23458-04-0 trans-Khellactone is a natural product isolated and purified from plants.
CSN16505 Skimmin 93-39-0 Skimmin, a natural product isolated and purified from the herbs of Hydrangea paniculata with anti-inflammatory activity, can significantly improve renal function and suppress the IgG deposition as well as the development of glomerular lesions in a rat model of membranous glomerulonephritis, suppress diabetic nephropathy in rats effectively, and may slow down the renal fibrosis by regulating TGF-β1 signal pathway, and show cytotoxic effect on CAOV-4 cell line, with an IC50 of 70.03 ug/mL.
CSN15640 Scopolin 531-44-2 Scopolin, a natural product isolated and purified from the herb of Scopolia japonica, can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis,and this compound may be a potent agent for angiogenesis related diseases and can serve as a structural base for screening more potent synthetic analogs.
CSN16631 Scoparone 120-08-1 Scoparone, a natural product isolated and purified from the herbs of Artemisia scoparia, with antifungal, antianginal, antioxidant, immunosuppression and vasorelaxation effects, protects against carbon tetrachloride-induced liver injury, is a very efficient inhibitor of ultraviolet radiation -induced lipid peroxidation and damage, and a phytoalexin associated with resistance of citrus to Phytophthora citrophthora.
CSN20546 Rutamarin 13164-05-1 Rutamarin is a natural product isolated and purified from Ruta angustifolia Pers..
CSN16251 Psoralidin 18642-23-4 Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L. with anticancer and chemopreventive properties, inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation.
CSN16448 Psoralen 66-97-7 Psoralen, an ingredient from Fructus Psoraleae, intercalates with DNA, inhibiting DNA synthesis and cell division and showing anticancer activity.
CSN16616 Praeruptorin D 73069-28-0 Praeruptorin D, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can significantly inhibit the infiltration of activated polymorphonuclear leukocytes (PMNs) and decrease the levels of TNF-α and IL-6 in bronchoalveolar lavage fluid at the same dose, suppresses LPS induced Nuclear Factor-kappa B (NF-κB) pathway activation in the lung by decreasing the cytoplasmic loss of inhibitor κB-α (IκB-α) protein and inhibiting the translocation of p65 from cytoplasm to nucleus.
CSN16616 Praeruptorin D 73069-28-0 Praeruptorin D, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can significantly inhibit the infiltration of activated polymorphonuclear leukocytes (PMNs) and decrease the levels of TNF-α and IL-6 in bronchoalveolar lavage fluid at the same dose, suppresses LPS induced Nuclear Factor-kappa B (NF-κB) pathway activation in the lung by decreasing the cytoplasmic loss of inhibitor κB-α (IκB-α) protein and inhibiting the translocation of p65 from cytoplasm to nucleus.
CSN16138 Pimpinellin 131-12-4 Pimpinellin, a natural product isolated and purified from the fruits of Psoralea corylifolia L.
CSN13863 Phellopterin 2543-94-4 Phellopterin, a natural product isolated and purified from the roots of Saposhnikovia divaricata, is a partial agonist of the central benzodiazepine receptors in vitro, shows cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM, and reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.
CSN14577 Peucedanol 3'-O-Glucoside 65891-61-4 Peucedanol 3'O-glucoside is a natural product isolated and purified from plants.
CSN19790 Oxypeucedanin 737-52-0 Oxypeucedanin is a natural product with anti-tumor activity, isolated and purified from the root of Angelica dahurica.
CSN19789 Norbraylin 60796-64-7 Norbraylin is a natural product isolated and purified from the roots of Toddalia asiatica.
CSN19936 Nodakenin 495-31-8 Nodakenin is a natural product isolated and purified from the root of Angelica biserrata (Shan et Yuan) Yuan et Shan. with anti-aggregatory, antibacterial, anti-allergic, anti- inflammator, and memory-enhancing effects.
CSN14575 Marmin 14957-38-1 Marmin, a natural product isolated and purified from the herbs of Citrus maxima with potent anti-ulcer, antibacterial, fungicidal, and algicidal properties, can inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca2+ release from the intracellular store and the Ca2+ influx through voltage-dependent Ca2+ channels, is potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists by interacting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor, shows a cell-growth inhibitory effect against L1210 and K562 in vitro.
CSN14575 Marmin 14957-38-1 Marmin, a natural product isolated and purified from the herbs of Citrus maxima with potent anti-ulcer, antibacterial, fungicidal, and algicidal properties, can inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca2+ release from the intracellular store and the Ca2+ influx through voltage-dependent Ca2+ channels, is potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists by interacting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor, shows a cell-growth inhibitory effect against L1210 and K562 in vitro.
CSN10152 Isoscopoletin 776-86-3 Isoscopoletin is a natural product isolated and purified from the herbs of Paederia scandens (Lour.) Merr.
CSN16367 Isopimpinellin 482-27-9 Isopimpinellin is an inhibitor of 7,12-Dimethylbenz(a)anthracene which is initiator of skin tumors or breast cancers, is isolated from the roots of Pimpinella saxifraga., reported to use in the management of breast cancers.
CSN19385 Isoimperatorin 482-45-1 Isoimperatorin is a natural occuring acetylcholinesterase inhibitor with IC50 value of 74.6μM, extracted from Angelica dahurica and Angelica koreana.
CSN16604 Isobergapten 482-48-4 Isobergapten, a natural product isolated and purified from the fruits of Citrus medica L., shows anti-proliferative activity and causes G2/M arrest at concentrations of 0.05-15.0 μM, and is the principal constituents responsible for the antimycobacterial activity of the roots of Heracleum maximum.
CSN16369 Imperatorin 482-44-0 Imperatorin is a naturally occuring multiple-target inhibitor of NOS with IC50 value of 9.2 μM, BChE with IC50 value of 31.4 μM, a potent calcium antagonist on vascular smooth muscle. It is also a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM.
CSN13981 Heraclenin 2880-49-1 Heraclenin, a natural product isolated and purified from the fruits of Citrus aurantium L., induces apoptosis in Jurkat leukemia cells in mechanistically different ways.
CSN19923 Fraxinol 486-28-2 Fraxinol is a natural product isolated and purified from the bark of Fraxinus chinensis Roxb.
CSN16387 Esculin 531-75-9 Esculin is a glucoside isolated and purified from the peel of Aesculus hippocastanum L., possessing antiflogistic, cytostatic, and antimutagenic properties, and is used for the treatment of various peripheral vascular disorders and in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria).
CSN19958 Columbianadin 5058-13-9 Columbianadin, a natural product isolated and purified from the herbs of Angelicae pubescens with analgesic, anti-inflammatory, calcium-channel blocking, and platelet aggregation inhibiting functions, can effectively suppress the growth of colon cancer cells, low concentration (up to 25 μM) of CBN induces apoptosis, and high concentration (50 μM) of CBN induces necroptosis, demonstrates that CBN has the potential to be a candidate in the development of anti-cancer agent derived from natural products.
CSN14231 cis-Methylkhellactone 20107-13-5 cis-Methylkhellactone is a natural product isolated and purified from plants.
CSN14576 Cedrelopsin 19397-28-5 Cedrelopsin is a natural product isolated and purified from Melicope borbonica with antifungal activity.
CSN15661 Byacangelicin 482-25-7 Byakangelicin, a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor from the roots of Angelica dahurica, is an aldose reductase inhibitor and induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes.
CSN14218 Auraptenol 1221-43-8 Auraptenol, a natural product isolated and purified from the fruits of Citrus aurantium with robust antidepressant-like efficacy in mice.
CSN19299 Angelicin 523-50-2 Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity.
CSN14580 4'-O-Methylcoumestrol 1690-62-6 4'O-Methylcoumestrol is a natural product isolated and purified from plants.
CSN19953 (±)-Praeruptorin A 73069-25-7 (±)-Praeruptorin A, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation, has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis, and can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro.
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