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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17117 | 2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid | 74711-43-6 | Zaltoprofen is an inhibitor of COX with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively, can be used for treatment of arthritis. |
| CSN20511 | Vitacoxib | 1374128-90-1 | Vitacoxib is an imidazole derivative and a COX-2 selective inhibitor to be marketed for veterinary use as nonsteroidal anti-inflammatory drugs. |
| CSN16812 | Triflusal | 322-79-2 | Triflusal inhibits the production of thromboxane-B2 in platelets irreversibly by acetylating cycloxygenase-1. |
| CSN22580 | 1-Methyl-5-p-toluoylpyrrole-2-acetic acid | 26171-23-3 | Tolmetin is a cyclooxygenase inhibitor used as a non-steroidal anti-inflammatory agent. |
| CSN22602 | TFAP | 1011244-68-0 | TFAP is a cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor (IC50 = 0.80 and 210 µM against ovine COX-1 and COX-2, respectively). |
| CSN24305 | Sulindac sulfone | 59973-80-7 | Sulindac sulfone inhibited K-ras-dependent COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production. |
| CSN20354 | SC-560 | 188817-13-2 | SC-560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). It inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production and significantly reduces ovarian surface epithelial tumor growth in vivo. |
| CSN23106 | SC-236 | 170569-86-5 | SC-236 is an orally active inhibitor of COX-2. SC-236 displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision. |
| CSN16453 | 2-Hydroxybenzoic acid | 69-72-7 | Salicylic acid, a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity. |
| CSN13702 | (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(2-(hydroxymethyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triol | 138-52-3 | Salicin is a non-selective COX-1 and COX-2 inhibitor, it is a phenol β-glycosid isolated and purified from the peel of Salix alba L.and shows anti-inflammatory effects. |
| CSN16640 | 7,8-Dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(13H)-one | 84-26-4 | Rutaecarpine, a COX-2 inhibitor, is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs. |
| CSN16719 | 4-(4-(Methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one | 162011-90-7 | Rofecoxib is a potent inhibitor of the COX2-dependent production of PGE2 in human osteosarcoma cells with IC50 of 26±10 nM and Chinese hamster ovary cells expressing human COX-2 with IC50 of 18±7 nM. |
| CSN19948 | Roburic acid | 6812-81-3 | Roburic acid, a natural product isolated and purified from the roots of Gentiana macrophylla, inhibits COX-1 and COX-2. |
| CSN24044 | Propacetamol hydrochloride | 66532-86-3 | Propacetamol HCl is the hydrochloride form of Propacetamol, which is a prodrug of paracetamol (acetaminophen) with improved water solubility. Propacetamol is an analgesic drug delivered by IV when oral application of NSAID is not appropriate or contradicted. |
| CSN13885 | N-(4-Ethoxyphenyl)acetamide | 62-44-2 | Phenacetin is a non-opioid analgesic used in treatment of pain-relieving and fever-reducing. |
| CSN15473 | Perilloxin | 263249-77-0 | Perilloxin, a natural product isolated and purified from the stems of Perilla frutescens var. acuta., possesses inhibitory activities against cyclooxygenase-1,with IC(50) values of 23.2 mM. |
| CSN13805 | Parecoxib | 198470-84-7 | Parecoxib is a potent and selective COX2 inhibitor. |
| CSN18175 | Paradol | 27113-22-0 | Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site, it's a pungent phenolic substance isolated and purified from ginger and other Zingiberaceae plants. |
| CSN21767 | NPPB | 107254-86-4 | NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 µM and inhibitor of cyclooxygenase (IC50 = 8 µM). |
| CSN21186 | Naproxen etemesil | 385800-16-8 | Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 2.2 and 1.3 μg/mL, respectively in cell assay. |
| CSN20384 | Mofezolac | 78967-07-4 | Mofezolac is a highly selective COX1 inhibitor that counteracts inflammatory state both in vitro and in vivo models of neuroinflammation. |
| CSN12893 | 4-Hydroxy-2-methyl-N-(5-methylthiazol-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide | 71125-38-7 | Meloxicam is a nonsteroidal anti-inflammatory agent with selectivity for COX2 (IC50 = 11.8 μM) over COX1 (IC50 = 143 μM) in in vitro assays. It shows potent anti-inflammatory, antipyretic, and analgesic effects with low gastrointestinal toxicity. |
| CSN20674 | Mavacoxib | 170569-88-7 | Mavacoxib is a veterinary drug used to treat pain and inflammation in dogs with degenerative joint disease. It acts as a COX-2 inhibitor. |
| CSN18716 | 2-(2-((2-Chloro-6-fluorophenyl)amino)-5-methylphenyl)acetic acid | 220991-20-8 | Lumiracoxib is a COX2 selective inhibitor and a non-steroidal anti-inflammatory drug (NSAID), which inhibits COX2 with IC50 and Ki values of 0.14 μM and 0.06 μM and inhibits COX1 with Ki of 3 μM. |
| CSN23658 | Loxoprofen sodium | 80382-23-6 | Loxoprofen Sodium is a non-selective cyclooxygenase inhibitor, a nonsteroidal anti-inflammatory drug (NSAID) working by reducing the synthesis of prostaglandins from arachidonic acid. |
| CSN16607 | Loganin | 18524-94-2 | Loganin is a naturally occuring iridoid glycoside with antioxidant, hepatoprotective and neuroprotective effects, as well as a COX-1 inhbitor with IC50 value of 3.55 µM, suppressing the formation of TNF-α, and diminishing the production of nitric oxide. |
| CSN15928 | Licofelone | 156897-06-2 | Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis. |
| CSN16782 | Ketorolac | 74103-06-3 | Ketorolac, a non-selective COX inhibitor with IC50s of 1.23 μM and 3.50 μM for COX1 and COX2, is a non-steroidal anti-inflammatory drug. |
| CSN12756 | Indomethacin | 53-86-1 | Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling. |
| CSN21951 | 2-(4-(1-Oxoisoindolin-2-yl)phenyl)butanoic acid | 63610-08-2 | Indobufen is a platelet aggregation inhibitor and a reversible cyclooxygenase inhibitor. It has been used in studying the supportive care and prevention of Atrial Fibrillation. |
| CSN20329 | Imrecoxib | 395683-14-4 | Imrecoxib is a selective COX-2 inhibitor. |
| CSN16702 | Iguratimod | 123663-49-0 | Iguratimod is a selective inhibitor of COX2 (IC50 = 20 μM/7.7 μg/mL) and several inflammatory cytokines including interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor, it's an anti-inflammatory agent. |
| CSN13298 | 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one | 36062-05-2 | Hexahydrocurcumin is a natural compound which posesses anticancer and anti-inflammatory activities and is a selective COX-2 inhibitor. |
| CSN12744 | 2-(3-Trifluoromethylanilino)benzoic Acid | 530-78-9 | Flufenamic Acid is a COX inhibitor and prevents formation of prostaglandins, binds to and reduce the activity of prostaglandin F synthase and activate TRPC6, it is a NSAID drug. |
| CSN17511 | FK 3311 | 116686-15-8 | FK 3311 is a selective inhibitor of COX-2 and an antiinflammatory agent. |
| CSN12948 | Firocoxib | 189954-96-9 | Firocoxib is a potent and selective COX2 inhibitor with IC50 of 0.13 μM. |
| CSN16177 | 2',4'-Difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid | 22494-42-4 | Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a cyclooxygenase Inhibitor. |
| CSN16174 | Diclofenac Sodium Salt | 15307-79-6 | Diclofenac sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. |
| CSN12864 | 2-(2,6-Dichloroanilino)phenylacetic Acid | 15307-86-5 | Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. |
| CSN16853 | 2-(6-Chloro-9H-carbazol-2-yl)propanoic acid | 53716-49-7 | Carprofen reduces inflammation by inhibition of COX-2 with IC50 of 30 nM, does not interfere with COX-1 activity. |
| CSN18760 | Bromfenac sodium | 91714-93-1 | Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. |
| CSN20901 | Beta-elemonicacid | 28282-25-9 | Beta-elemonic acid is a triterpene isolated from boswellia that exhibits anticancer activity. |
| CSN15857 | Otenaproxesul | 1226895-20-0 | ATB-346 is a hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. |
| CSN16343 | 2,4,5-Trimethoxybenzaldehyde | 4460-86-0 | Asaronaldehyde is a COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1, it's a natural product isolated and purified from the rhizoma of Acorus tatarinowii Schott. |
| CSN12868 | Amfenac Sodium Hydrate | 61618-27-7 | Amfenac Sodium Monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively. |
| CSN16856 | Sulfinpyrazone | 57-96-5 | (±)-Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules. |
| CSN20549 | S-(+)-Ketoprofen | 22161-81-5 | (S)-Ketoprofen is a potent inhibitor of COX with IC50 of 1.9 and 27 nM for COX1 and 2 respectively. |
| CSN17031 | (S)-2-(4-Isobutylphenyl)propanoic acid | 51146-56-6 | (S)-(+)-Ibuprofen, the S-enantiomer of ibuprofen, is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor. S(+)-Ibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways |
| CSN17018 | (R)-(-)-Ibuprofen | 51146-57-7 | (R)-(-)-Ibuprofen, the less active enantiomer of ibuprofen, is an inhibitor of COX1 and 2 with IC50 of 13 and 370 μM respectively, it's a nonsteroidal anti-inflammatory. |
| CSN64595 | 2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid | 74711-43-6 |
