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CXCR
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN17345 | 2-(2-(4-(3-Phenoxybenzyl)piperazin-1-yl)ethoxy)ethan-1-ol | 874911-96-3 | ZK756326 is a full agonist of CCR8(Chemokine receptor 8) with an IC50 of 1.8 μM, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1. |
CSN15996 | WZ811 | 55778-02-4 | WZ811 is a small molecular and potency CXCR4 antagonist with EC50 of 0.3 nM. |
CSN23188 | Vuf 11222 | 1414376-84-3 | VUF-11222 is a high affinity non-peptide CXCR3 agonist (pKi = 7.2). |
CSN23717 | USL311 | 1373268-67-7 | USL311 is a selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4[1]. |
CSN18633 | UNBS5162 | 956590-23-1 | UNBS5162 is a naphthalimide and a hydrolysis product of UNBS3157 that decreases CXCL chemokine expression in experimental prostate cancers and the mean antiproliferative activity IC50 value is 17.9 μM for 9 cancer cell lines. |
CSN68805 | Tannic acid | 1401-55-4 | Tannins (commonly referred to as tannic acid) are water-soluble polyphenols that are present in many plant foods. They have been reported to be responsible for decreases in feed intake, growth rate, feed efficiency, net metabolizable energy, and protein digestibility in experimental animals. |
CSN27389 | SX-682 | 1648843-04-2 | SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity. |
CSN17557 | SRT3190 | 1204707-73-2 | SRT3190 is CXCR2 ligand. |
CSN17556 | SRT3109 | 1204707-71-0 | SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions. |
CSN19351 | SCH 563705 | 473728-58-4 | SCH-563705 is a potent dual CXCR2 (IC50= 1.3 nM)/CXCR1 (IC50= 7.3 nM) antagonist. |
CSN12829 | Navarixin | 473727-83-2 | SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively. |
CSN13174 | SCH 546738 | 906805-42-3 | SCH 546738 is a potent and non-competitive small molecule CXCR3 antagonist with Ki of 0.4 nM . |
CSN17197 | SB225002 | 182498-32-4 | SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM, showing > 150-fold selectivity over CXCR1 and four other 7-TMRs. |
CSN23103 | SB-332235 | 276702-15-9 | SB-332235 is a potent and specific CXCR2 antagonist. SB-332235 effectively inhibited CS-induced neutrophilia in a dose-dependent manner. |
CSN23101 | SB-265610 | 211096-49-0 | SB-265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively). It inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo. |
CSN18171 | Reparixin L-lysine salt | 266359-93-7 | Reparixin L-lysine is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation,which has been shown to attenuate inflammatory responses in various injury models. |
CSN15950 | Reparixin | 266359-83-5 | Reparixin is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation, which has been shown to attenuate inflammatory responses in various injury models. |
CSN16151 | Plerixafor octahydrochloride | 155148-31-5 | Plerixafor 8HCl is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
CSN23012 | NVP CXCR2 20 | 1029521-30-9 | NVP CXCR2 20 is a potent and selective CXCR2 antagonist with IC50 of 40 nM. |
CSN18477 | NBI-74330 | 855527-92-3 | NBI-74330 is a small molecule antagonist for CXCR3, NBI-74330 demonstrates potent inhibition of [(125)I]CXCL10 and [(125)I]CXCL11 specific binding (K (i) of 1.5 and 3.2 nM, respectively. |
CSN21269 | MSX-130 | 4051-59-6 | MSX-130 is CXCR4 Antagonist. |
CSN18542 | MSX-122 | 897657-95-3 | MSX-122 is a small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions (IC50 = 10 nM). |
CSN21198 | LY2510924 | 1088715-84-7 | LY2510924 is an inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity. Upon subcutaneous administration, LY2510924 binds to the chemokine receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation. |
CSN32932 | Ladarixin sodium | 865625-56-5 | Ladarixin Sodium is a CXCR antagonist potentially for the treatment of type I diabetes. |
CSN32931 | Ladarixin | 849776-05-2 | Ladarixin is a dual, non-competitive, allosteric inhibitor of CXCR1 and CXCR2 interleukin-8 (IL-8A and IL-8B, respectively). |
CSN24505 | JMS-17-2 | 1380392-05-1 | JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. |
CSN22862 | IT1t dihydrochloride | 1092776-63-0 | IT1t 2HCl is a potent CXCR4 antagonist with IC50 of 1.1 nM. |
CSN22815 | FC131 | 606968-52-9 | FC 131 is a CXCR4 antagonist with IC50 of 126 nM. |
CSN18630 | Danirixin | 954126-98-8 | Danirixin is a small molecule, non-peptide, high affinity (IC50 for CXCL8 binding = 12.5 nM), selective, and reversible CXCR2 antagonist. |
CSN26625 | CXCR7 modulator 2 | 2227426-37-9 | CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM. |
CSN23143 | TC14012 | 368874-34-4 | CXCR4 antagonist; ACKR3 (CXCR7) agonist |
CSN22780 | CTCE-9908 | 1030384-98-5 | CTCE 9908 is a CXCR4 antagonist with antitumor activity. |
CSN32401 | Burixafor | 1191448-17-5 | Burixafor is an orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities. |
CSN18996 | Motixafortide | 664334-36-5 | BKT140 is a CXCR4 antagonist with an IC50 value of ~1 nM. |
CSN21987 | AZD8797 | 911715-90-7 | AZD8797 is an allosteric non-competitive and orally active modulator of the human CX3CR1 receptor which antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800 nM, respectively. |
CSN22921 | AZD-5069 | 878385-84-3 | AZD 5069 is a selective and reversible antagonist of CXCR2 that can inhibit CXCL8 binding to CXCR2 with pIC50 of 9.1. |
CSN22697 | Az 10397767 | 333742-63-5 | AZ 10397767 is a potent CXCR2 antagonist with IC50 of 1 nM. |
CSN19244 | ATI-2341 | 1337878-62-2 | ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. |
CSN18287 | AMG 487 | 473719-41-4 | AMG-487 is a small molecule antagonist of the chemokine receptor CXCR3 and inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3. |
CSN13161 | Mavorixafor | 558447-26-0 | AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. |
CSN24435 | Mavorixafor trihydrochloride | 2309699-17-8 | AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. |
CSN13824 | (S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine hydrochloride | 880549-30-4 | AMD-070 HCl is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. |
CSN18051 | AMD 3465 | 185991-24-6 | AMD 3465 is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1α-ligand binding (Ki = 41.7 nM). |
CSN16529 | AMD 3465 hexahydrobromide | 185991-07-5 | AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1α-ligand binding (Ki = 41.7 nM). |
CSN22622 | (±)-nbi 74330 | 473722-68-8 | (±)-NBI 74330 is a potent and selective CXCR3 antagonist that potently inhibits 125I-CXCL10 binding to CXCR3 with pKi of 8.13. |
CSN22618 | (±)-AMG 487 | 947536-03-0 | (±)-AMG 487 is an antagonist of CXCR3 that inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 with IC50 of 8.0 and 8.2 nM respectively. |
CSN51410 | ACT-1004-1239 | 2178049-58-4 | |
CSN73217 | (E)-N-(3-(2-Fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide | 1378524-41-4 | |
CSN83400 | CCX-777 | 1226686-36-7 |