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CXCR

CXCR

货号 产品名 CAS号 信息
CSN17345 Zk756326 874911-96-3 ZK756326 is a full agonist of CCR8（Chemokine receptor 8） with an IC50 of 1.8 μM, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.
CSN15996 WZ811 55778-02-4 WZ811 is a small molecular and potency CXCR4 antagonist with EC50 of 0.3 nM.
CSN23188 Vuf 11222 1414376-84-3 VUF-11222 is a high affinity non-peptide CXCR3 agonist (pKi = 7.2).
CSN23717 USL311 1373268-67-7 USL311 is a selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4[1].
CSN18633 UNBS5162 956590-23-1 UNBS5162 is a naphthalimide and a hydrolysis product of UNBS3157 that decreases CXCL chemokine expression in experimental prostate cancers and the mean antiproliferative activity IC50 value is 17.9 μM for 9 cancer cell lines.
CSN68805 Tannic acid 1401-55-4 Tannins (commonly referred to as tannic acid) are water-soluble polyphenols that are present in many plant foods. They have been reported to be responsible for decreases in feed intake, growth rate, feed efficiency, net metabolizable energy, and protein digestibility in experimental animals.
CSN27389 SX-682 1648843-04-2 SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity.
CSN17557 SRT3190 1204707-73-2 SRT3190 is CXCR2 ligand.
CSN17556 SRT3109 1204707-71-0 SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions.
CSN19351 SCH 563705 473728-58-4 SCH-563705 is a potent dual CXCR2 (IC50= 1.3 nM)/CXCR1 (IC50= 7.3 nM) antagonist.
CSN12829 Navarixin 473727-83-2 SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.
CSN13174 SCH 546738 906805-42-3 SCH 546738 is a potent and non-competitive small molecule CXCR3 antagonist with Ki of 0.4 nM .
CSN17197 SB225002 182498-32-4 SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM, showing > 150-fold selectivity over CXCR1 and four other 7-TMRs.
CSN23103 SB-332235 276702-15-9 SB-332235 is a potent and specific CXCR2 antagonist. SB-332235 effectively inhibited CS-induced neutrophilia in a dose-dependent manner.
CSN23101 SB-265610 211096-49-0 SB-265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively). It inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.
CSN18171 Reparixin L-lysine salt 266359-93-7 Reparixin L-lysine is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation,which has been shown to attenuate inflammatory responses in various injury models.
CSN15950 Reparixin 266359-83-5 Reparixin is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation, which has been shown to attenuate inflammatory responses in various injury models.
CSN16151 Plerixafor octahydrochloride 155148-31-5 Plerixafor 8HCl is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
CSN23012 NVP CXCR2 20 1029521-30-9 NVP CXCR2 20 is a potent and selective CXCR2 antagonist with IC50 of 40 nM.
CSN18477 NBI-74330 855527-92-3 NBI-74330 is a small molecule antagonist for CXCR3, NBI-74330 demonstrates potent inhibition of [(125)I]CXCL10 and [(125)I]CXCL11 specific binding (K (i) of 1.5 and 3.2 nM, respectively.
CSN21269 MSX-130 4051-59-6 MSX-130 is CXCR4 Antagonist.
CSN18542 MSX-122 897657-95-3 MSX-122 is a small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions (IC50 = 10 nM).
CSN21198 LY2510924 1088715-84-7 LY2510924 is an inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity. Upon subcutaneous administration, LY2510924 binds to the chemokine receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation.
CSN32932 Ladarixin sodium 865625-56-5 Ladarixin Sodium is a CXCR antagonist potentially for the treatment of type I diabetes.
CSN32931 Ladarixin 849776-05-2 Ladarixin is a dual, non-competitive, allosteric inhibitor of CXCR1 and CXCR2 interleukin-8 (IL-8A and IL-8B, respectively).
CSN24505 JMS-17-2 1380392-05-1 JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM.
CSN22862 IT1t dihydrochloride 1092776-63-0 IT1t 2HCl is a potent CXCR4 antagonist with IC50 of 1.1 nM.
CSN22815 FC131 606968-52-9 FC 131 is a CXCR4 antagonist with IC50 of 126 nM.
CSN18630 Danirixin 954126-98-8 Danirixin is a small molecule, non-peptide, high affinity (IC50 for CXCL8 binding = 12.5 nM), selective, and reversible CXCR2 antagonist.
CSN26625 CXCR7 modulator 2 2227426-37-9 CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM.
CSN23143 TC14012 368874-34-4 CXCR4 antagonist; ACKR3 (CXCR7) agonist
CSN22780 CTCE-9908 1030384-98-5 CTCE 9908 is a CXCR4 antagonist with antitumor activity.
CSN32401 Burixafor 1191448-17-5 Burixafor is an orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities.
CSN18996 Motixafortide 664334-36-5 BKT140 is a CXCR4 antagonist with an IC50 value of ~1 nM.
CSN21987 AZD8797 911715-90-7 AZD8797 is an allosteric non-competitive and orally active modulator of the human CX3CR1 receptor which antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800 nM, respectively.
CSN22921 AZD-5069 878385-84-3 AZD 5069 is a selective and reversible antagonist of CXCR2 that can inhibit CXCL8 binding to CXCR2 with pIC50 of 9.1.
CSN22697 Az 10397767 333742-63-5 AZ 10397767 is a potent CXCR2 antagonist with IC50 of 1 nM.
CSN19244 ATI-2341 1337878-62-2 ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.
CSN18287 AMG 487 473719-41-4 AMG-487 is a small molecule antagonist of the chemokine receptor CXCR3 and inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3.
CSN13161 Mavorixafor 558447-26-0 AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
CSN24435 Mavorixafor trihydrochloride 2309699-17-8 AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
CSN13824 (S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine hydrochloride 880549-30-4 AMD-070 HCl is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
CSN18051 AMD 3465 185991-24-6 AMD 3465 is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1α-ligand binding (Ki = 41.7 nM).
CSN16529 AMD 3465 hexahydrobromide 185991-07-5 AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1α-ligand binding (Ki = 41.7 nM).
CSN22622 (±)-nbi 74330 473722-68-8 (±)-NBI 74330 is a potent and selective CXCR3 antagonist that potently inhibits 125I-CXCL10 binding to CXCR3 with pKi of 8.13.
CSN22618 (±)-AMG 487 947536-03-0 (±)-AMG 487 is an antagonist of CXCR3 that inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 with IC50 of 8.0 and 8.2 nM respectively.
CSN51410 ACT-1004-1239 2178049-58-4
CSN73217 (E)-N-(3-(2-Fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide 1378524-41-4
CSN83400 CCX-777 1226686-36-7
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