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CXCR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN15996 | WZ811 | 55778-02-4 | WZ811 is a small molecular and potency CXCR4 antagonist with EC50 of 0.3 nM. |
| CSN18633 | UNBS5162 | 956590-23-1 | UNBS5162 is a naphthalimide and a hydrolysis product of UNBS3157 that decreases CXCL chemokine expression in experimental prostate cancers and the mean antiproliferative activity IC50 value is 17.9 μM for 9 cancer cell lines. |
| CSN23324 | Tannic Acid | 5424-20-4 | Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM. |
| CSN27389 | SX-682 | 1648843-04-2 | SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity. |
| CSN17197 | SB-225002 | 182498-32-4 | SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM, showing > 150-fold selectivity over CXCR1 and four other 7-TMRs. |
| CSN15950 | Reparixin | 266359-83-5 | Reparixin is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation, which has been shown to attenuate inflammatory responses in various injury models. |
| CSN12664 | Plerixafor | 110078-46-1 | Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
| CSN16151 | Plerixafor 8HCl | 155148-31-5 | Plerixafor 8HCl is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
| CSN21198 | LY2510924 | 1088715-84-7 | LY2510924 is an inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity. Upon subcutaneous administration, LY2510924 binds to the chemokine receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation. |
| CSN24505 | JMS-17-2 | 1380392-05-1 | JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. |
| CSN18996 | BKT140 | 664334-36-5 | BKT140 is a CXCR4 antagonist with an IC50 value of ~1 nM. |
| CSN18287 | AMG-487 | 473719-41-4 | AMG-487 is a small molecule antagonist of the chemokine receptor CXCR3 and inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3. |
| CSN24435 | Mavorixafor 3HCl | 2309699-17-8 | AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. |