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Dehydrogenase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN29529 | 11beta-Hydroxyprogesterone | 600-57-7 | The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo. 11beta-Hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. |
| CSN23145 | TC HSD 21 | 330203-01-5 | TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors[1]. |
| CSN22561 | Sodium dichloroacetate | 2156-56-1 | Sodium 2,2-dichloroacetate is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 183 and 80 μM for PDK2 and PDK4 respectively, with tumor growth inhibition properties. |
| CSN22557 | RRx-001 | 925206-65-1 | RRx-001 is a potent inhibitor of glucose 6-phosphate dehydrogenase (G6PD). |
| CSN26191 | R162 | 64302-87-0 | R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) and represses glioma cell growth. |
| CSN24124 | Pyrazinecarboxylic acid | 98-97-5 | Pyrazinoic Acid inhibits Mycobacterial Coenzyme A biosynthesis by binding to aspartate decarboxylase PanD. |
| CSN21792 | 2,2-Dihydroxy-1-phenylethan-1-one | 1075-06-5 | Phenylglyoxal Hydrate is a potent inhibitor of mitochondrial aldehyde dehydrogenase (ALDH), binding the arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties. |
| CSN11676 | Penthiopyrad | 183675-82-3 | Penthiopyrad is a carboxamide fungicide used to control a broad spectrum of diseases on large variety of corps and inhibits fungal respiration by binding to mitochondrial respiratory complex II. |
| CSN23240 | Oxaloacetic acid | 328-42-7 | Oxaloacetic Acid substrate for malate dehydrogenase and oxaloacetate decarboxylase. Oxaloacetic Acid is an inhibitor of SDH. |
| CSN16915 | Merimepodib | 198821-22-6 | Merimepodiba is a noncompetitive inhibitor of IMPDH (Inosine monophosphate dehydrogenase) with broad spectrum antiviral activities. |
| CSN27650 | LY 345899 | 10538-99-5 | LY 345899, a Folate analog, is an inhibitor of methylene tetrahydrofolate dehydrogenase MTHFD1 (IC50 = 96 nM, Ki = 18 nM) and MTHFD2 (IC50 = 96 nM). |
| CSN24832 | LDH-A Inhibitor III | 1269802-68-7 | LDH-A Inhibitor III is a potent and reversible LDH-A inhibitor. |
| CSN26126 | HQNO | 341-88-8 | HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2. |
| CSN28430 | GSK2837808A | 1445879-21-9 | GSK2837808A is a potent and selective LDHA and LDHB inhibitor with IC50 values of 2.6nM and 43nM for LDHA and LDHB, respectively. It reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells. |
| CSN33152 | Galloflavin | 568-80-9 | Galloflavin is an inhibitor of both LDH-A and -B with Ki values of 5.46 μM (LDH-A) and 15.06 μM (LDH-B), respectively. It inhibits both human LDH isoforms by preferentially binding the free enzyme, without competing with the substrate or cofactor. |
| CSN27755 | G6PDi-1 | 2457232-14-1 | G6PDi-1 is a reversible and noncompetitive G6PDH inhibitor with IC50 value of 0.07µM. |
| CSN27625 | FX-11 | 213971-34-7 | FX11 is a selective, reversible, and NADH competitive inhibitor of LDHA with Ki value of 8µM. |
| CSN95822 | Dimethyl malonate | 108-59-8 | Dimethylmalonate is a competitive SDH (succinate dehydrogenase) inhibitor. |
| CSN27658 | DHODH-IN-11 | 1263303-95-2 | DHODH-IN-11, a leflunomide derivative, is a weak inhibitor of dihydroorotate dehydrogenase (DHODH) with pKa of 5.03. |
| CSN26336 | Chloramphenicol succinate sodium | 982-57-0 | Chloramphenicol succinate sodium, a prodrug of chloramphenicol, is competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity. |
| CSN20448 | Carbenoxolone | 5697-56-3 | Carbenoxolone is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication. |
| CSN20425 | Carbenoxolone disodium | 7421-40-1 | Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication. |
| CSN16289 | BVT 2733 | 376640-41-4 | BVT 2733 is a small molecule, non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1(11β-HSD1). |
| CSN25383 | Brequinar Sodium | 96201-88-6 | Brequinar sodium is a potent inhibitor of the mitochondrial DHODH, a rate-limiting enzyme in the pyrimidine de novo nucleotide synthesis. |
| CSN25384 | Brequinar | 96187-53-0 | Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. |
| CSN20563 | Bms-823778 | 1140898-87-8 | BMS-823778 is an orally available potent and selective inhibitor of 11-β-hydroxysteroid-dehydrogenase 1 (11βHSD-1). BMS-823778 is an antihyperglycaemic that may be a potential candidate for Type 2 diabetes treatment. |
| CSN25625 | BAY-2402234 | 2225819-06-5 | BAY 2402234 is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor. It potently inhibited proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range in vitro and exhibited strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models. |
| CSN20651 | AZD 4017 | 1024033-43-9 | AZD4017 is a potent, selective, and orally bioavailable11β-HSD1 inhibitor (11β-hydroxysteroid dehydrogenase type 1 inhibitor). Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome. |
| CSN25633 | LDHA-IN-4 | 1370290-34-8 | AZ 33 is a Lactate Dehydrogenase A inhibitor with IC50 value of 0.5μM. |
| CSN22691 | ASP-9521 | 1126084-37-4 | ASP 9521 is a potent and selective AKR1C3 inhibitor with IC50 of 11 nM for human AKR1C3. |
| CSN22599 | Ammonium Glycyrrhizinate | 1407-03-0 | Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses. |
| CSN43933 | AG-636 | 1623416-31-8 | AG-636 is a potent, reversible, selective and orally active DHODH inhibitor with IC50 value of 17nM. |
| CSN23342 | 3-Methylpyrazole | 1453-58-3 | 3-Methylpyrazole is a nitrification inhibitor of nitrification in soil. |
| CSN27552 | 2-Bromoacetamide | 683-57-8 | 2-Bromoacetamide can inactivate alcohol dehydrogenase. |
| CSN22939 | (R)-GNE-140 | 2003234-63-5 | (R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor with IC50s of 3 nM and 5 nM for LDHA and LDHB respectively. |
| CSC24124 | Pyrazinecarboxylic acid | 98-97-5 | |
| CSC25383 | Brequinar Sodium | 96201-88-6 | |
| CSN27116 | Inosinic acid (disodium)(hydrate)(1:2:X) | 352195-40-5 | |
| CSN24459 | 5-Ethynylpyrimidine-2,4(1H,3H)-dione | 59989-18-3 | |
| CSN27808 | Farudodstat | 1035688-66-4 | |
| CSN28984 | 11-Beta-hydroxyandrostenedione | 382-44-5 | |
| CSN43225 | AZD8329 | 1048668-70-7 | |
| CSN43773 | (R)-BMS-816336 | 1009583-83-8 | |
| CSN70482 | ABT-384 | 868623-40-9 | |
| CSN70904 | AMG-221 | 1095565-81-3 | |
| CSN80096 | 2-((R)-4-(2-Fluoro-4-(methylsulfonyl)phenyl)-2-methylpiperazin-1-yl)-N-((1R,2s,3S,5S,7S)-5-hydroxyadamantan-2-yl)pyrimidine-4-carboxamide | 1346554-47-9 | |
| CSN81054 | HSD-016 | 946396-92-5 | |
| CSN104428 | (S)-1-((3-Chloro-2-methylphenyl)sulfonyl)-N-cyclohexylpiperidine-3-carboxamide | 872506-67-7 | |
| CSN108119 | (5-(1H-Pyrazol-4-yl)thiophen-3-yl)((1R,3r,5S)-3-hydroxy-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone | 1346013-80-6 |
