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Dehydrogenase

Dehydrogenase

货号 产品名 CAS号 信息
CSN12146 Trilostane 13647-35-3 Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase for Cushing's syndrome.
CSN11548 Teriflunomide(Random Configuration) 108605-62-5 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN13699 Teriflunomide 163451-81-8 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN22561 Sodium 2,2-dichloroacetate 2156-56-1 Sodium 2,2-dichloroacetate is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 183 and 80 μM for PDK2 and PDK4 respectively, with tumor growth inhibition properties.
CSN24124 Pyrazinecarboxylic acid 98-97-5 Pyrazinoic Acid inhibits Mycobacterial Coenzyme A biosynthesis by binding to aspartate decarboxylase PanD.
CSN21792 Phenylglyoxal hydrate 1075-06-5 Phenylglyoxal Hydrate is a potent inhibitor of mitochondrial aldehyde dehydrogenase (ALDH), binding the arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.
CSN23240 Oxalacetic Acid 328-42-7 Oxaloacetic Acid substrate for malate dehydrogenase and oxaloacetate decarboxylase. Oxaloacetic Acid is an inhibitor of SDH.
CSN19396 Mycophenolic Acid 24280-93-1 Mycophenolic Acid is an an immunosuppresant agent with a potent inibition of IMPDH (inosine monophosphate dehydrogenase) and potent anti-proliferative activity, it can be isolated from several Penicillium species.
CSN16132 Mycophenolate Mofetil 128794-94-5 Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.
CSN16462 Leflunomide 75706-12-6 Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 μM, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis.
CSN11234 Isovaleramide 541-46-8 Isovaleramide, a liver alcohol dehydrogenases inhibitor, is an anticonvulsant molecule isolated from Valeriana pavonii.
CSN26126 HQNO 341-88-8 HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2.
CSN19090 GNE-140 Racemate 1802977-61-2 GNE-140 racemate is a LDHA inhibitor.
CSN16160 Glycyrrhizic Acid 1405-86-3 Glycyrrhizic Acid is a naturally occuring non-selective and competitive 11β-hydroxysteroid dehydrogenase inhibitor with protective effect against glucocorticoid-induced osteoporosis. It also inhibited HMGB1.
CSN16654 Gimeracil 103766-25-2 Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood and inhibits homologous recombination.
CSN19521 Fomepizole 7554-65-6 Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol.
CSN20383 Crocetin 27876-94-4 Crocetin, a saffron derivative, is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer.
CSN15809 CPI-613 95809-78-2 CPI-613 is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer.
CSN20448 Carbenoxolone 5697-56-3 Carbenoxolone is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.
CSN20425 Carbenoxolone Disodium 7421-40-1 Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.
CSN25384 Brequinar 96187-53-0 Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses.
CSN25625 BAY 2402234 2225819-06-5 BAY 2402234 is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor. It potently inhibited proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range in vitro and exhibited strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models.
CSN25633 AZ 33 1370290-34-8 AZ 33 is a Lactate Dehydrogenase A inhibitor with IC50 value of 0.5μM.
CSN22691 ASP 9521 1126084-37-4 ASP 9521 is a potent and selective AKR1C3 inhibitor with IC50 of 11 nM for human AKR1C3.
CSN23342 3-Methylpyrazole 1453-58-3 3-Methylpyrazole is a nitrification inhibitor of nitrification in soil.
CSN27552 2-Bromoacetamide 683-57-8 2-Bromoacetamide can inactivate alcohol dehydrogenase.
CSN22939 (R)-GNE-140 2003234-63-5 (R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor with IC50s of 3 nM and 5 nM for LDHA and LDHB respectively.
CSN27658 DHODH-IN-11   1263303-95-2
CSN25383 Brequinar sodium 96201-88-6
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