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Dehydrogenase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12146 | Trilostane | 13647-35-3 | Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase for Cushing's syndrome. |
| CSN11548 | Teriflunomide(Random Configuration) | 108605-62-5 | Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. |
| CSN13699 | Teriflunomide | 163451-81-8 | Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. |
| CSN22561 | Sodium 2,2-dichloroacetate | 2156-56-1 | Sodium 2,2-dichloroacetate is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 183 and 80 μM for PDK2 and PDK4 respectively, with tumor growth inhibition properties. |
| CSN24124 | Pyrazinecarboxylic acid | 98-97-5 | Pyrazinoic Acid inhibits Mycobacterial Coenzyme A biosynthesis by binding to aspartate decarboxylase PanD. |
| CSN21792 | Phenylglyoxal hydrate | 1075-06-5 | Phenylglyoxal Hydrate is a potent inhibitor of mitochondrial aldehyde dehydrogenase (ALDH), binding the arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties. |
| CSN23240 | Oxalacetic Acid | 328-42-7 | Oxaloacetic Acid substrate for malate dehydrogenase and oxaloacetate decarboxylase. Oxaloacetic Acid is an inhibitor of SDH. |
| CSN19396 | Mycophenolic Acid | 24280-93-1 | Mycophenolic Acid is an an immunosuppresant agent with a potent inibition of IMPDH (inosine monophosphate dehydrogenase) and potent anti-proliferative activity, it can be isolated from several Penicillium species. |
| CSN16132 | Mycophenolate Mofetil | 128794-94-5 | Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. |
| CSN16462 | Leflunomide | 75706-12-6 | Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 μM, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis. |
| CSN11234 | Isovaleramide | 541-46-8 | Isovaleramide, a liver alcohol dehydrogenases inhibitor, is an anticonvulsant molecule isolated from Valeriana pavonii. |
| CSN26126 | HQNO | 341-88-8 | HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2. |
| CSN19090 | GNE-140 Racemate | 1802977-61-2 | GNE-140 racemate is a LDHA inhibitor. |
| CSN16160 | Glycyrrhizic Acid | 1405-86-3 | Glycyrrhizic Acid is a naturally occuring non-selective and competitive 11β-hydroxysteroid dehydrogenase inhibitor with protective effect against glucocorticoid-induced osteoporosis. It also inhibited HMGB1. |
| CSN16654 | Gimeracil | 103766-25-2 | Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood and inhibits homologous recombination. |
| CSN19521 | Fomepizole | 7554-65-6 | Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol. |
| CSN20383 | Crocetin | 27876-94-4 | Crocetin, a saffron derivative, is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer. |
| CSN15809 | CPI-613 | 95809-78-2 | CPI-613 is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer. |
| CSN20448 | Carbenoxolone | 5697-56-3 | Carbenoxolone is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication. |
| CSN20425 | Carbenoxolone Disodium | 7421-40-1 | Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication. |
| CSN25384 | Brequinar | 96187-53-0 | Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. |
| CSN25625 | BAY 2402234 | 2225819-06-5 | BAY 2402234 is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor. It potently inhibited proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range in vitro and exhibited strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models. |
| CSN25633 | AZ 33 | 1370290-34-8 | AZ 33 is a Lactate Dehydrogenase A inhibitor with IC50 value of 0.5μM. |
| CSN22691 | ASP 9521 | 1126084-37-4 | ASP 9521 is a potent and selective AKR1C3 inhibitor with IC50 of 11 nM for human AKR1C3. |
| CSN23342 | 3-Methylpyrazole | 1453-58-3 | 3-Methylpyrazole is a nitrification inhibitor of nitrification in soil. |
| CSN27552 | 2-Bromoacetamide | 683-57-8 | 2-Bromoacetamide can inactivate alcohol dehydrogenase. |
| CSN22939 | (R)-GNE-140 | 2003234-63-5 | (R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor with IC50s of 3 nM and 5 nM for LDHA and LDHB respectively. |
| CSN27658 | DHODH-IN-11 | 1263303-95-2 | |
| CSN25383 | Brequinar sodium | 96201-88-6 |