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Dehydrogenase

Dehydrogenase

货号 产品名 CAS号 信息
CSN29529 11beta-Hydroxyprogesterone 600-57-7 The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo. 11beta-Hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.
CSN23145 TC HSD 21 330203-01-5 TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors[1].
CSN22561 Sodium dichloroacetate 2156-56-1 Sodium 2,2-dichloroacetate is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 183 and 80 μM for PDK2 and PDK4 respectively, with tumor growth inhibition properties.
CSN22557 RRx-001 925206-65-1 RRx-001 is a potent inhibitor of glucose 6-phosphate dehydrogenase (G6PD).
CSN26191 R162 64302-87-0 R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) and represses glioma cell growth.
CSN24124 Pyrazinecarboxylic acid 98-97-5 Pyrazinoic Acid inhibits Mycobacterial Coenzyme A biosynthesis by binding to aspartate decarboxylase PanD.
CSN21792 2,2-Dihydroxy-1-phenylethan-1-one 1075-06-5 Phenylglyoxal Hydrate is a potent inhibitor of mitochondrial aldehyde dehydrogenase (ALDH), binding the arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.
CSN11676 Penthiopyrad 183675-82-3 Penthiopyrad is a carboxamide fungicide used to control a broad spectrum of diseases on large variety of corps and inhibits fungal respiration by binding to mitochondrial respiratory complex II.
CSN23240 Oxaloacetic acid 328-42-7 Oxaloacetic Acid substrate for malate dehydrogenase and oxaloacetate decarboxylase. Oxaloacetic Acid is an inhibitor of SDH.
CSN16915 Merimepodib 198821-22-6 Merimepodiba is a noncompetitive inhibitor of IMPDH (Inosine monophosphate dehydrogenase) with broad spectrum antiviral activities.
CSN27650 LY 345899 10538-99-5 LY 345899, a Folate analog, is an inhibitor of methylene tetrahydrofolate dehydrogenase MTHFD1 (IC50 = 96 nM, Ki = 18 nM) and MTHFD2 (IC50 = 96 nM).
CSN24832 LDH-A Inhibitor III 1269802-68-7 LDH-A Inhibitor III is a potent and reversible LDH-A inhibitor.
CSN26126 HQNO 341-88-8 HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2.
CSN28430 GSK2837808A   1445879-21-9 GSK2837808A is a potent and selective LDHA and LDHB inhibitor with IC50 values of 2.6nM and 43nM for LDHA and LDHB, respectively. It reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells.
CSN33152 Galloflavin 568-80-9 Galloflavin is an inhibitor of both LDH-A and -B with Ki values of 5.46 μM (LDH-A) and 15.06 μM (LDH-B), respectively. It inhibits both human LDH isoforms by preferentially binding the free enzyme, without competing with the substrate or cofactor.
CSN27755 G6PDi-1 2457232-14-1 G6PDi-1 is a reversible and noncompetitive G6PDH inhibitor with IC50 value of 0.07µM.
CSN27625 FX-11 213971-34-7 FX11 is a selective, reversible, and NADH competitive inhibitor of LDHA with Ki value of 8µM.
CSN27658 DHODH-IN-11   1263303-95-2 DHODH-IN-11, a leflunomide derivative, is a weak inhibitor of dihydroorotate dehydrogenase (DHODH) with pKa of 5.03.
CSN20383 Transcrocetin 27876-94-4 Crocetin, a saffron derivative, is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer.
CSN26336 Chloramphenicol succinate sodium 982-57-0 Chloramphenicol succinate sodium, a prodrug of chloramphenicol, is competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity.
CSN20448 Carbenoxolone 5697-56-3 Carbenoxolone is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.
CSN20425 Carbenoxolone disodium 7421-40-1 Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.
CSN16289 BVT 2733 376640-41-4 BVT 2733 is a small molecule, non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1(11β-HSD1).
CSN25383 Brequinar Sodium 96201-88-6 Brequinar sodium is a potent inhibitor of the mitochondrial DHODH, a rate-limiting enzyme in the pyrimidine de novo nucleotide synthesis.
CSN25384 Brequinar 96187-53-0 Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses.
CSN20563 Bms-823778 1140898-87-8 BMS-823778 is an orally available potent and selective inhibitor of 11-β-hydroxysteroid-dehydrogenase 1 (11βHSD-1). BMS-823778 is an antihyperglycaemic that may be a potential candidate for Type 2 diabetes treatment.
CSN25625 BAY-2402234 2225819-06-5 BAY 2402234 is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor. It potently inhibited proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range in vitro and exhibited strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models.
CSN20651 AZD 4017 1024033-43-9 AZD4017 is a potent, selective, and orally bioavailable11β-HSD1 inhibitor (11β-hydroxysteroid dehydrogenase type 1 inhibitor). Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome.
CSN25633 LDHA-IN-4 1370290-34-8 AZ 33 is a Lactate Dehydrogenase A inhibitor with IC50 value of 0.5μM.
CSN22691 ASP-9521 1126084-37-4 ASP 9521 is a potent and selective AKR1C3 inhibitor with IC50 of 11 nM for human AKR1C3.
CSN22599 Ammonium Glycyrrhizinate 1407-03-0 Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses.
CSN43933 AG-636 1623416-31-8 AG-636 is a potent, reversible, selective and orally active DHODH inhibitor with IC50 value of 17nM.
CSN23342 3-Methylpyrazole 1453-58-3 3-Methylpyrazole is a nitrification inhibitor of nitrification in soil.
CSN27552 2-Bromoacetamide 683-57-8 2-Bromoacetamide can inactivate alcohol dehydrogenase.
CSN22939 (R)-GNE-140 2003234-63-5 (R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor with IC50s of 3 nM and 5 nM for LDHA and LDHB respectively.
CSN27116 Inosinic acid (disodium)(hydrate)(1:2:X) 352195-40-5
CSN24459 5-Ethynylpyrimidine-2,4(1H,3H)-dione 59989-18-3
CSN27808 Farudodstat 1035688-66-4
CSN28984 11-Beta-hydroxyandrostenedione 382-44-5
CSN43225 AZD8329 1048668-70-7
CSN43773 (R)-BMS-816336 1009583-83-8
CSN70482 ABT-384 868623-40-9
CSN70904 AMG-221 1095565-81-3
CSN80096 2-((R)-4-(2-Fluoro-4-(methylsulfonyl)phenyl)-2-methylpiperazin-1-yl)-N-((1R,2s,3S,5S,7S)-5-hydroxyadamantan-2-yl)pyrimidine-4-carboxamide 1346554-47-9
CSN81054 HSD-016 946396-92-5
CSN104428 (S)-1-((3-Chloro-2-methylphenyl)sulfonyl)-N-cyclohexylpiperidine-3-carboxamide 872506-67-7
CSN108119 (5-(1H-Pyrazol-4-yl)thiophen-3-yl)((1R,3r,5S)-3-hydroxy-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone 1346013-80-6
CSN102809 2-(3-(1-(4-Chlorophenyl)cyclopropyl)-[1,2,4]triazolo[4,3-a]pyridin-8-yl)propan-2-ol 1140897-32-0
CSN103747 4-(5-(2-(4-Chloro-2,6-difluorophenoxy)propan-2-yl)-4-methyl-4H-1,2,4-triazol-3-yl)-3-fluorobenzamide 1204178-50-6
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