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Dehydrogenase

Dehydrogenase

货号 产品名 CAS号 信息
CSN18402 Vidofludimus 717824-30-1 Vidofludimus is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH, used as a immunosuppressive drug.
CSN12146 Trilostane 13647-35-3 Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase for Cushing's syndrome.
CSN11548 (E/Z)-Teriflunomide 108605-62-5 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN13699 Teriflunomide 163451-81-8 Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.
CSN19396 (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid 24280-93-1 Mycophenolic Acid is an an immunosuppresant agent with a potent inibition of IMPDH (inosine monophosphate dehydrogenase) and potent anti-proliferative activity, it can be isolated from several Penicillium species.
CSN16132 2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate 128794-94-5 Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.
CSN19079 ML390 2029049-79-2 ML390 is a human DHODH inhibitor that induces differentiation in acute myeloid leukemia.
CSN16462 Leflunomide 75706-12-6 Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 μM, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis.
CSN22446 LDH-IN-1 1964515-43-2 LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.
CSN11234 Isovaleramide 541-46-8 Isovaleramide, a liver alcohol dehydrogenases inhibitor, is an anticonvulsant molecule isolated from Valeriana pavonii.
CSN19090 GNE-140 racemate 1802977-61-2 GNE-140 racemate is a LDHA inhibitor.
CSN16160 (2S,3S,4S,5R,6R)-6-(((2S,3R,4S,5S,6S)-6-Carboxy-2-(((3S,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid 1405-86-3 Glycyrrhizic Acid is a naturally occuring non-selective and competitive 11β-hydroxysteroid dehydrogenase inhibitor with protective effect against glucocorticoid-induced osteoporosis. It also inhibited HMGB1.
CSN16654 5-Chloro-4-hydroxypyridin-2(1H)-one 103766-25-2 Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood and inhibits homologous recombination.
CSN19521 4-Methyl-1H-pyrazole 7554-65-6 Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol.
CSN20383 Crocetin 27876-94-4 Crocetin, a saffron derivative, is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer.
CSN15809 Devimistat 95809-78-2 CPI-613 is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer.
CSN20222 BMS-816336 1009583-20-3 BMS-816336, a hydroxyl-substituted adamantyl acetamide, has been identified as a potent inhibitor against human 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1) enzyme (IC50 3.0 nM) with > 10000 fold selectivity over human 11β-hydroxysteroid dehydrogenase type 2(11β-HSD2).
CSN19747 BI-135585 1114561-85-1 BI-135585 is a potent and selective 11β-HSD1 inhibitor for treating Type 2 diabetes.
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