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Dehydrogenase
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN18402 | Vidofludimus | 717824-30-1 | Vidofludimus is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH, used as a immunosuppressive drug. |
CSN12146 | Trilostane | 13647-35-3 | Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase for Cushing's syndrome. |
CSN11548 | (E/Z)-Teriflunomide | 108605-62-5 | Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. |
CSN13699 | Teriflunomide | 163451-81-8 | Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. |
CSN19396 | (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid | 24280-93-1 | Mycophenolic Acid is an an immunosuppresant agent with a potent inibition of IMPDH (inosine monophosphate dehydrogenase) and potent anti-proliferative activity, it can be isolated from several Penicillium species. |
CSN16132 | 2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate | 128794-94-5 | Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. |
CSN19079 | ML390 | 2029049-79-2 | ML390 is a human DHODH inhibitor that induces differentiation in acute myeloid leukemia. |
CSN16462 | Leflunomide | 75706-12-6 | Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 μM, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis. |
CSN22446 | LDH-IN-1 | 1964515-43-2 | LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively. |
CSN11234 | Isovaleramide | 541-46-8 | Isovaleramide, a liver alcohol dehydrogenases inhibitor, is an anticonvulsant molecule isolated from Valeriana pavonii. |
CSN19090 | GNE-140 racemate | 1802977-61-2 | GNE-140 racemate is a LDHA inhibitor. |
CSN16160 | (2S,3S,4S,5R,6R)-6-(((2S,3R,4S,5S,6S)-6-Carboxy-2-(((3S,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid | 1405-86-3 | Glycyrrhizic Acid is a naturally occuring non-selective and competitive 11β-hydroxysteroid dehydrogenase inhibitor with protective effect against glucocorticoid-induced osteoporosis. It also inhibited HMGB1. |
CSN16654 | 5-Chloro-4-hydroxypyridin-2(1H)-one | 103766-25-2 | Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood and inhibits homologous recombination. |
CSN19521 | 4-Methyl-1H-pyrazole | 7554-65-6 | Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol. |
CSN20383 | Crocetin | 27876-94-4 | Crocetin, a saffron derivative, is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer. |
CSN15809 | Devimistat | 95809-78-2 | CPI-613 is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer. |
CSN20222 | BMS-816336 | 1009583-20-3 | BMS-816336, a hydroxyl-substituted adamantyl acetamide, has been identified as a potent inhibitor against human 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1) enzyme (IC50 3.0 nM) with > 10000 fold selectivity over human 11β-hydroxysteroid dehydrogenase type 2(11β-HSD2). |
CSN19747 | BI-135585 | 1114561-85-1 | BI-135585 is a potent and selective 11β-HSD1 inhibitor for treating Type 2 diabetes. |