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DHFR

DHFR

货号 产品名 CAS号 信息
CSN16458 Trimethoprim 738-70-5 Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR) which is necessary for the synthesis of purines, amino acids, and thymidylic acid, with prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively). Trimethoprim is used mainly in the prophylaxis and treatment of urinary tract infections.
CSN12806 5-(4-Chlorophenyl)-6-ethylpyrimidine-2,4-diamine 58-14-0 Pyrimethamine inhibits multidrug and toxin extrusion (MATE) transporter potently, it also inhibits dihydrofolate reductase (DHFR), used for protozoal infections and interferes with tetrahydrofolic acid synthesis from folic acid. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.
CSN21745 Proguanil 500-92-5 Proguanil is an inhibitor of dihydrofolate reductase (DHFR). It is antimalarial prodrug metabolized to the active metabolite cycloguanil.
CSN13592 (2S)-2-(4-(1-(2,4-Diaminopteridin-6-yl)pent-4-yn-2-yl)benzamido)pentanedioic acid 146464-95-1 Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.
CSN11667 (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid   137281-23-3 Pemetrexed is an antifolate and antimetabolite for TS(thymidylate synthase), DHFR(dihydrofolate reductase) and GARFT(glycinamide ribonucleotide formyltransferase) with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
CSN16714 Sodium (S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate 150399-23-8 Pemetrexed Disodium is an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
CSN12796 Pemetrexed disodium hemipenta hydrate 357166-30-4 Pemetrexed disodium is an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
CSN12754 Pemetrexed disodium heptahydrate 357166-29-1 Pemetrexed disodium is a guanine-derived antineoplastic agent that functions as a nucleic acid synthesis inhibitor through its binding to, and inhibition of, thymidylate synthase.
CSN16844 (S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid 59-05-2 Methotrexate, an antifolate compound, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH and can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.
CSN22453 LY309887 127228-54-0 LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 6.5 nM, and has antitumor activity.
CSN22451 LY 222306 154446-98-7 LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.
CSN26629 Lometrexol hydrate 1435784-14-7 Lometrexol hydrate (DDATHF hydrate), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity[1][2].
CSN12983 Levomefolic acid 31690-09-2 Levomefolic acid is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
CSN12982 Levomefolate calcium 151533-22-1 Levomefolate Calcium is an artificial form of folate.
CSN12564 Calcium (4-(((2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamate 1492-18-8 Leucovorin calcium is a reduced form of folic acid.
CSN21969 Iclaprim 192314-93-5 Iclaprim is a new selective bacterial dihydrofolate reductase inhibitor, which can inhibit the growth of S. aureus (MRSA) with an MIC90 of 0.06 μg/mL.
CSN10090 Folinic acid 58-05-9 Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate.
CSN11049 Folinic acid calcium salt pentahydrate 6035-45-6 Folinic acid is a reduced folic acid, which is used in combination with other chemotherapy drugs.
CSN21604 5-(3,4-Dimethoxybenzyl)pyrimidine-2,4-diamine 5355-16-8 Diaveridine is a dihydrofolate reductase (DHFR) inhibitor with Ki of 11.5 nM, also an antibacterial agent.
CSN23284 Diaveridine hydrochloride 2507-23-5 Diaveridine HCl is a coccidiostat and inhibits dihydrofolate reductase. It can prevente folic acid synthesis in species of Pneumocystis. Diaveridine also has genotoxicity.
CSN23377 Cycloguanil HCl 152-53-4 Cycloguanil HCl is HCl form of cycloguanil which is a metabolite of proguanil and a dihydrofolate reductase inhibitor.
CSN12746 Calcium N5-methyltetrahydrofolate 26560-38-3 Calcium N5-methyltetrahydrofolate is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers.
CSN10527 Levoleucovorin Calcium 80433-71-2 Calcium levofolinate is the calcium salt of levoleucovorin, which is the enantiomerically active form of folinic acid.
CSN22341 Pelitrexol 446022-33-9 AG 2037 (Pelitrexol) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT).
CSN26146 1-(4-Chlorophenyl)biguanide hydrochloride 4022-81-5 1-(4-Chlorophenyl)biguanide is a guanide derivative that can inhibit dihydrofolate reductase (DHFR).
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