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Diterpenoids

Diterpenoids

货号 产品名 CAS号 信息
CSN20194 α-Cembrenediol 57605-80-8 VEGFR inhibitor TC1 acts in angiogenesis inhibitory in multiple breast cancer cell lines by significantly reducing the activated VEGFR2 levels.
CSN19412 Triptonide 38647-11-9 Triptonide, a natural product isolated and purified from the herb of Tripterygium wilfordii Hook.f. with antileukemic, antitumor, anti-inflammatory activities, is effective in the treatment of autoimmune diseases.
CSN19415 Triptolide 38748-32-2 Triptolide, a diterpene triepoxide extracted from the Chinese herb Tripterygium wilfordii, functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein.
CSN12034 Tanshinone IIB 17397-93-2 Tanshinone IIB (TSB), a natural product isolated and purified from the roots of Salvia miltiorrhiza, can significantly inhibit the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner. Tanshinone IIB showed inhibitory effect on PL(pro) with IC50 value of 10.7μM and less inhibitory effect on 3CLpro with IC50 value of 24.8μM.
CSN17003 Steviol 471-80-7 Steviol is the aglycon derivative of steviol glycosides, which are natural sweeteners isolated from S. rebaudiana. Steviol inhibits human organic anion transporters (hOATs) in uptake assays using murine cells from the S2 segment of proximal tubules. Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity.
CSN25589 Rosmariquinone 27210-57-7 Rosmariquinone showed inhibitory effect on PL(pro) and 3CLpro with IC50 values of 30μM and 21.1μM, respectively.
CSN15999 Rebaudioside A 58543-16-1 Rebaudioside A, an α-glucosidase inhibitor with IC50 of 35.01 μg/mL. is a steviol glycoside isolated and purified from the leaves of Stevia rebaudiana Bertoni..
CSN11720 Pimaric Acid 127-27-5 Pimaric acid is a natural product isolated and purified from the herbs of Aralia cordata having a potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α-induced human aortic smooth muscle cells.
CSN11720 Pimaric Acid 127-27-5 Pimaric acid is a natural product isolated and purified from the herbs of Aralia cordata having a potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α-induced human aortic smooth muscle cells.
CSN20394 Ovatodiolide 3484-37-5 Ovatodiolide is a macrocyclic diterpenoid isolated from Anisomeles indica, showing therapeutic potential for the treatment of allergic asthma.
CSN19419 Oridonin 28957-04-2 Oridonin is an antitumor agent, a diterpenoid purified from Rabdosia rubescens. Oridonin interacts with the cysteine 279 of NLRP3 NACHT domain through a covalent bond, abolishes NLRP3-NEK7 interaction, and inhibits consequent activation of NLRP3 inflammasome.
CSN15611 Neoprzewaquinone A 630057-39-5 Neoprzewaquinone A, a natural product isolated and purified from the roots of Salvia miltiorrhiza, has algicidal effect on M.
CSN14246 Nagilactone C 24338-53-2 Nagilactone C, a natural product isolated and purified from the herbs of Podocarpus neriifolius, possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 mg/mL, respectively.
CSN14246 Nagilactone C 24338-53-2 Nagilactone C, a natural product isolated and purified from the herbs of Podocarpus neriifolius, possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 mg/mL, respectively.
CSN18827 Lathyrol 34420-19-4 Lathyrol is a natural product.
CSN16605 Kirenol 52659-56-0 Kirenol is a naturall occuring diterpenoid found in S. orientalis, which possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities.
CSN20179 Isopimaric Acid 5835-26-7 Isopimaric acid, a natural product isolated and purifed from the herbs of Daemonorops draco Blume, potently opens large conductance Ca-activated K+ channels and also possibly has an antagonistic interaction with reserpine which may render the antibiotics inactive.
CSN19405 Honokiol 35354-74-6 Honokiol inhibits Akt activation and enhances ERK1/ERK2 phosphorylation, is a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis with anticancer activities in a variety of cancer cell lines.
CSN19411 Ginkgolide C 15291-76-6 Ginkgolide C can enhance the cardiac function of rats in the body, is a flavone isolated from Ginkgo biloba leaves.
CSN14586 Galanolactone 115753-79-2 Galanolactone, a natural product isolated and purified from the rhizomes of Zingiber officinale Roscoe with cytotoxic activity, has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes, and inhibits nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM.
CSN25431 Estragole 140-67-0 Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability. Estragole displays anti-toxoplasma activity.
CSN14581 Eriocalyxin B 84745-95-9 Eriocalyxin B, a natural product isolated and purified from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein.
CSN19917 Diosbulbin B 20086-06-0 Diosbulbin B, a natural product isolated and purified from the roots of Dioscorea bulbifera, has potential anti-tumor effects which may be related to influencing the immune system for the first time.
CSN16500 Dihydrotanshinone I 87205-99-0 Dihydrotanshinone I, a natural product isolated and purified from the roots of Salvia miltiorrhiza Bge., exhibits dose-dependent inhibition towards HLM-catalyzed propofol glucuronidation. Dihydrotanshinone I showed inhibitory effect on PL(pro) with IC50 value of 4.9μM and less inhibitory effect on 3CLpro with IC50 value of 14.4μM.
CSN19484 Deacetyltaxol 78432-77-6 Deacetyltaxol is a natural product isolated and purified from the barks of Taxus chinensis (Pilger) Rehd. with cytotoxicity in human glial and neuroblastoma cell-lines.
CSN19905 Crocin II 55750-84-0 Crocin, a natural product with anti-inflammatory, antihyperlipidemic, antidepressant and anti-apoptotic effects, can ameliorate CCl4-induced liver injury via inhibition of inflammatory cytokines, caspase3 and oxidative stress along with modulation of liver metabolizing enzymes favoring elimination of CCl4 toxic metabolite, it's isolated and purified from the stigma of Crocus sativus L..
CSN16599 Crocin 42553-65-1 Crocin, a natural product isolated and purified from the stigma of Crocus sativus L., can relax smooth muscles with a great potential to be a candidate for the treatment of asthma, protect liver and skeletal muscle tissue against exercise-induced oxidative damage by preventing reactive oxygen species (ROS) production, improve toxic effects of DZN via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta, protect rat gastric mucosa against ethanol-induced injury via anti-inflammatory, anti-oxidative, anti-apoptotic and mucin-secretagogue mechanisms that are probably mediated by enhanced PGE2 release, significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase, and also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3.
CSN20383 Crocetin 27876-94-4 Crocetin, a saffron derivative, is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer.
CSN19931 Carboxyatractyloside 77228-71-8 Carboxyatractyloside, a natural product isolated and purified from the roots of Atractylodes lancea (Thunb.) DC., induces the inhibitory effect of tamoxifen on nonspecific membrane permeability, and causes multiple organ dysfunction and can be fatal.
CSN20512 Cafestol 469-83-0 Cafestol is a bioactive substance isolated and extracted from coffee with potential medical uses.
CSN19460 Baccatin III 27548-93-2 Baccatin III is a precursor to the anti-cancer drug paclitaxel, it's a natural product isolated and purified from the barks of Taxus chinensis.
CSN19420 Andrographolide 5508-58-7 Andrographolide is a naturally occuring NF-κB inhibitor.
CSN18681 7beta-Hydroxylathyrol 34208-98-5 7beta-Hydroxylathyrol is a natural product.
CSN18327 20-Deoxyingenol 54706-99-9 20-Deoxyingenol is a natural compound.
CSN19770 14-Deoxyandrographolide 4176-97-0 14-Deoxyandrographolide, a natural product isolated and purified from the herbs of Andrographis paniculata (Burm.
CSN14101 14-Deoxy-11,12-Didehydroandrographolide 42895-58-9 14-Deoxy-11,12-didehydroandrographolide, herbs of Andrographis paniculata (Burm.
CSN14101 14-Deoxy-11,12-Didehydroandrographolide 42895-58-9 14-Deoxy-11,12-didehydroandrographolide, herbs of Andrographis paniculata (Burm.
CSN19449 10-Deacetylbaccatin III 32981-86-5 10-Deacetylbaccatin-III is an intermediate for taxol analog preparations.
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