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Diterpenoids
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12119 | (+)-Totarol | 511-15-9 | Totarol has anti-bacteria effect by restraining bacterial growth by perturbing the cell division and proliferation, including several pathogenic Gram-positive bacteria, mycobacterium tuberculosis. |
| CSN11984 | (2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl (4R,4aS,6aR,9S,11aR,11bS)-9-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylate | 57817-89-7 | Stevioside, a natural product isolated and purified from the leaves of Stevia rebaudiana, is a safe natural sweetener, has no allergic reactions, suited for both diabetics, and PKU patients, as well as for obese persons intending to lose weight by avoiding sugar supplements in the diet. Stevioside also exerts anti-inflammatory and anti-apoptotic properties by inhibiting the release of cytokines and the activation of TLR2 and proteins of the NF-κB and MAPK signaling pathways, as well as caspase-3 and Bax. Stevioside and steviol attenuate LPS-induced pro-inflammatory cytokine productions by affecting cytokine gene expression via IκBα/NF-κB signalling pathway. |
| CSN14239 | Pinusolide | 31685-80-0 | Pinusolide, a natural potent and specific PAF antagonist isolated and purified from the barks of Biota orientalis L., inhibits 5-lipoxygenase (5-LO)-dependent leukotriene C4 (LTC4) generation in immunoglobulin E (IgE)/Ag-induced bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner. |
| CSN14796 | Nagilactone B | 19891-51-1 | Nagilactone B, a natural product isolated and purified from the herbs of Podocarpus neriifolius, selectively activates LXR in macrophages and induces ABCA1- and ABCG1-mediated cholesterol efflux while exerting minimal effects on lipogenesis and lipid accumulation in liver, resulting in regression of atherosclerosis, and therefore might be a promising strategy for therapeutics. |
| CSN15324 | Kongensin A | 885315-96-8 | Kongensin A, a natural product isolated and purified from the herbs of Croton cascarilloides, is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications. |
| CSN16605 | Kirenol | 52659-56-0 | Kirenol is a naturall occuring diterpenoid found in S. orientalis, which possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities. |
| CSN14103 | Kaurenoic acid | 6730-83-2 | Kaurenoic Acid is a natural product isolated and purified from the herbs of Croton antisyphiliticus with anti-inflammatory property, the mechanisms may through inhibition of iNOS and COX-2 expression. Kaurenoic acid is an inducer of apoptosis, which is part of the innate mechanism of cell defense against neoplasia. Kaurenoic acid from A. continentalis may be a useful agent for inhibiting the cariogenic properties of S. mutans. |
| CSN12569 | (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione | 15291-77-7 | Ginkgolide B, an important active terpenoid from Ginkgo biloba leaves, a PAFR antagonist with IC50 of 3.6 μM, is reported to increase cell viability and decrease cell apoptosis. |
| CSN12568 | (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione | 15291-75-5 | Ginkgolide A is an antagonist of g-aminobutyric acid (GABA) with Ki of 14.5 μM and also can activate PAF. It is purified from the leaves of ginkgo biloba tree. |
| CSN10310 | Dehydroandrographolide | 134418-28-3 | Dehydroandrographolide is extracted from herbal medicine Andrographis paniculata (Burm f) Nees and alleviates oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS. |
| CSN10554 | Carnosol | 5957-80-2 | Carnosol, a natural product isolated and purified from the herbs of Rosmarinus officinalis L., enhances the sensitivity of chemoresistant cancer cells to chemotherapeutic agents. Carnosol may as an agonist of TRPA1 with an EC50 value of 12.46 µM. |
| CSN13458 | Bruceine D | 21499-66-1 | Bruceine D, a natural product isolated and purified from the barks of Ailanthus altissima, may have the potential to be used as a natural viricide, or a lead compound for viricides, inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW1990 and CAPAN-1, and induces cytotoxicity in Capan-2 cells via the induction of cellular apoptosis involving the mitochondrial pathway. |
| CSN15352 | Bisandrographolide A | 160498-00-0 | Bisandrographolide A, a natural product, activates TRPV4 channels, could play a role in some of the effects of Andrographis extract described in traditional medicine. |
| CSN15373 | Aphadilactone C | 1522004-70-1 | Aphadilactone C is a naturla product isolated and purified from Aphanamixis grandifolia with DGAT inhibitory and antimalarial activities. |
| CSN15042 | Adenanthin | 111917-59-0 | Adenanthin, a natural product isolated and purified from the herb of Rabdosia adenantha with antiinflammatory, antitumour, bacteriostatic, and antileukemic activities, is an NF-κB and nucleophilic cysteines inhibitor, and can serve as the development of Prx I– and Prx II–targeted therapeutic agents. |
