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DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

货号 产品名 CAS号 信息
CSN10789 VAL-083 23261-20-3 VAL-083 is a bi-functional alkylating agent and inhibits U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis.
CSN12081 Thio-TEPA 52-24-4 Thio-TEPA is an alkylating agent used to treat cancer, this molecule features tetrahedral phosphorus and is structurally akin to phosphate.
CSN12046 Temozolomide 85622-93-1 Temozolomide is a DNA-methylating agent and an alkylating cytostatic drug used in the treatment of some brain cancers, astrocytoma and glioblastoma multiforme.
CSN11987 Streptozocin 18883-66-4 Streptozocin is a potent DNA alkylator with antitumor effects, also used to induce diabete model.
CSN13611 SJG-136 232931-57-6 SJG-136 is a rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity.
CSN15939 RITA 213261-59-7 RITA induced both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks.
CSN11776 Procarbazine HCl 366-70-1 Procarbazine HCl, an antineoplastic chemotherapy drug, is an alkylating agent for the treatment of Hodgkin's lymphoma and certain brain cancers and also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyramine.
CSN11496 Palifosfamide 31645-39-3 Palifosfamide is the functional active metabolite of ifosfamide (IFOS), a bi-functional DNA alkylator being investigated as a potential therapy for the treatment of soft tissue sarcoma (STS).
CSN11626 Oxaliplatin 61825-94-3 Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
CSN11530 Nedaplatin 95734-82-0 Nedaplatin is a derivative of cisplatin and DNA damage agent.
CSN16956 Miriplatin 141977-79-9 Miriplatin is a platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).
CSN11325 Lomustine 13010-47-4 Lomustine is an alkylating nitrosourea compound used in chemotherapy. Lomustine (420 μM) triggers apoptosis through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively, in both medulloblastoma and normal human epithelial and fibroblast cells. Lomustine induces cell cycle delay in G2/M phase in medulloblastoma cells and up-regulates p21 protein level in a p53-independent manner in HFSN1 cells.
CSN16324 Ifosfamide 3778-73-2 Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
CSN10722 Cyclofosphamide 50-18-0 Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
CSN10657 Cisplatin 15663-27-1 Cisplatin is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts. It is used, alone or in combination therapy, in the treatment of several types of cancer, including testicular, ovarian, cervical, bladder, and lung cancers. Cisplatin also inhibits the RecA recombinase of M. tuberculosis (IC50 = 2 µM), blocking protein splicing and cell growth.
CSN20048 CC-1065 69866-21-3 CC-1065 is a DNA alkylator agent belonging to duocarmycins family that inhibits DNA synthesis.
CSN21213 CB 1954 21919-05-1 CB 1954 is an anticancer prodrug used in gene therapy research and is activated by NAD(P)H Quinone Oxidoreductase 2.
CSN17085 Carmustine 154-93-8 Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
CSN10551 Carboplatin 41575-94-4 Carboplatin is a chemotherapy drug by binding to DNA and interfering with the cell's repair mechanism.
CSN10512 Busulfan 55-98-1 Busulfan is a bifunctional alkylating agent.
CSN18706 Altretamine 645-05-6 Altretamine is an alkylating agent proposed as an antineoplastic.
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