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DNA Methyltransferase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12234 | Zebularine | 3690-10-6 | Zebularine is a DNA methylation inhibitor which forms a covalent complex with DNA methyltransferases, it also inhibits cytidinedeaminase with Ki of 2 μM. |
| CSN16078 | RG108 | 48208-26-0 | RG108 is a DNA methyltransferase inhibitor with IC50 of 115 nM. |
| CSN11506 | N-Acetylprocainamide | 32795-44-1 | N-Acetylprocainamide is the N-acetylated metabolite of Procainamide, and is a Class III antiarrhythmic agent. |
| CSN15937 | Lomeguatrib | 192441-08-0 | Lomeguatrib, an inhibitor of DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) with IC50 of 0.009 μM in cell-free extracts from HeLa S3 cells, is a modified guanine base. |
| CSN12608 | Decitabine | 2353-33-5 | Decitabine is a potent inhibitor of DNA methyltransferase with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively. |
| CSN18530 | DC_05 | 890643-16-0 | DC_05 is a non-nucleoside DNMT1 inhibitor (IC50=10.3 μM) with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases. |
| CSN13714 | 6-Thioguanine | 154-42-7 | 6-Thioguanine belongs to the thiopurine family of drugs that also include mercaptopurine and azathioprine, which are examples of antimetabolites, and is a purine analogue of the nucleobase guanine. It was found to inhibit SARS-CoV PLpro. |
| CSN25528 | 5−Fluoro−2'−deoxycytidine | 10356-76-0 | 5−Fluoro−2'−deoxycytidine is a DNMT inhibitor which forms covalent links with the cysteine residue in the DNMT active site. |
| CSN19354 | 5-Azacytidine | 320-67-2 | 5-Azacytidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. |
