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DNA Methyltransferase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN20797 | γ-Oryzanol | 11042-64-1 | γ-Oryzanol is a phytochemical with membrane antioxidant, naturally occurring in crude rice bran oil, can be used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass. |
| CSN12234 | Zebularine | 3690-10-6 | Zebularine is a DNA methylation inhibitor which forms a covalent complex with DNA methyltransferases, it also inhibits cytidinedeaminase with Ki of 2 μM. |
| CSN15868 | SGI-1027 | 1020149-73-8 | SGI-1027 is a potent and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively. |
| CSN16078 | RG108 | 48208-26-0 | RG108 is a DNA methyltransferase inhibitor with IC50 of 115 nM. |
| CSN18251 | O6BTG-octylglucoside | 382607-78-5 | O6BTG-C8-βGlu is a glucose-conjugated MGMT inhibitor with IC50 values of 32 nM in vitro and 10 nM on HeLa S3 cell and the parent compound O6BTG's IC50 is 9 nM (in vitro). |
| CSN11506 | N-Acetylprocainamide | 32795-44-1 | N-Acetylprocainamide is the N-acetylated metabolite of Procainamide, and is a Class III antiarrhythmic agent. |
| CSN15937 | Lomeguatrib | 192441-08-0 | Lomeguatrib, an inhibitor of DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) with IC50 of 0.009 μM in cell-free extracts from HeLa S3 cells, is a modified guanine base. |
| CSN26548 | EML741 | 2328074-38-8 | for G9a. EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated[1]. |
| CSN12608 | Decitabine | 2353-33-5 | Decitabine is a potent inhibitor of DNA methyltransferase with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively. |
| CSN18303 | DC_517 | 500017-70-9 | DC_517 is a selective non-nucleoside inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 = 1.7 μM). |
| CSN18530 | DC-05 | 890643-16-0 | DC_05 is a non-nucleoside DNMT1 inhibitor (IC50=10.3 μM) with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases. |
| CSN13714 | 6-Thioguanine | 154-42-7 | 6-Thioguanine belongs to the thiopurine family of drugs that also include mercaptopurine and azathioprine, which are examples of antimetabolites, and is a purine analogue of the nucleobase guanine. It was found to inhibit SARS-CoV PLpro. 6-Thioguanine disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. |
| CSN25528 | 5-Fluoro-2'-deoxycytidine | 10356-76-0 | 5−Fluoro−2'−deoxycytidine is a DNMT inhibitor which forms covalent links with the cysteine residue in the DNMT active site. |
| CSN19354 | 5-Azacytidine | 320-67-2 | 5-Azacytidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. |
