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DNA/RNA Synthesis

DNA/RNA Synthesis

货号 产品名 CAS号 信息
CSN24863 ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate 58-97-9 Uridine 5'-monophosphate is a nucleotide that is used as a monomer in RNA.
CSN16447 Pyrimidine-2,4(1H,3H)-dione 66-22-8 Uracil is one of the four nucleobases in the nucleic acid of RNA can be used for drug delivery and as a pharmaceutical.
CSN12504 trans-4-(aminomethyl)cyclohexane-1-carboxylic acid 1197-18-8 Tranexamic acid is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.
CSN19417 4-(Aminomethyl)cyclohexanecarboxylic acid 701-54-2 Tranexamic Acid (Random Configuration) is a medication used to treat or prevent excessive blood loss from major trauma, surgery, tooth removal, nose bleeds, and heavy menstruation.Inducing single-and double-strand breaks in DNA, base damage, and cell death.
CSN43681 TK216 1903783-48-1 TK-216, an analog of YK-4-279 inhibitor, is a potent and selective EWS-FLI1 inhibitor. TK-216 is in early clinical development for the treatment of Ewing sarcoma.
CSN21982 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one 18771-50-1 Tetrahydrouridine is potent inhibitor of cytidine deaminase (CDA).
CSN51391 FEN1-IN-SC13 2098776-03-3 SC13 specifically inhibits FEN1 activity. It suppresses cancer cell proliferation and induces chromosome instability and cytotoxicity in cells, as well as sensitizes cancer cells to DNA damage-inducing therapeutic modalities and impedes cancer progression in a mouse model.
CSN32990 5-(4-(tert-Butyl)benzamido)-N-hydroxy-1H-indole-2-carboxamide 2563874-93-9 Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Inhibitors;TNF-alpha (ARE sequence)/ELAV-Like protein 1 (HuR) Interaction Inhibitors
CSN32991 1-(5-(Pyridin-3-yl)-1,3,4-oxadiazol-2-yl)naphthalen-2-ol 2247176-87-8 Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Inhibitors
CSN32994 RRM1 Inhibitor 5 1271734-91-8 Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Inhibitors
CSN32992 (S)-6-(2-(2-(1,3-Dioxoisoindolin-2-yl)acetamido)-2-methylpropanamido)-2-(4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)butanamido)hexanoic acid 1819992-33-0 Ribonucleoside-Diphosphate Reductase Large Subunit (RRM1) Inhibitors
CSN26441 RG7800 1449598-06-4 RG7800 HCl is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; has the potential to treat spinal muscular atrophy.
CSN17016 (E)-5-(4-Hydroxystyryl)benzene-1,3-diol 501-36-0 Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 μM for Adenylyl cyclase, IKKβ, DNA polymerase α and δ, respectively.
CSN11829 (S)-2-(5-(Methyl((2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)amino)thiophene-2-carboxamido)pentanedioic acid 112887-68-0 Raltitrexed is an inhibitor of thymidylate synthase with IC50 of 9 nM in L1210 cell.
CSN16448 7H-Furo[3,2-g]chromen-7-one 66-97-7 Psoralen, an ingredient from Fructus Psoraleae, intercalates with DNA, inhibiting DNA synthesis and cell division and showing anticancer activity.
CSN21764 Nitracrine 4533-39-5 Nitracrine, an acridine antineoplastic used in ovarian tumors, can inhibit RNA synthesis. 
CSN25485 N2N2-Dimethylguanosine 2140-67-2 N,N-Dimethylguanosine, an urinary nucleoside, is a primary degradation product of tRNA.
CSN19748 MS-444 150045-18-4 MS-444 is a chrysanthone-like compound specifically inhibit the HuR from binding ARE-RNAs.
CSN43591 Metarrestin 1443414-10-5 Metarrestin is a specific inhibitor of perinuclear compartment (PNC).
CSN22455 LysRs-IN-1 281676-77-5 LysRs-IN-1 is a Lysyl-tRNA synthetase (LysRs) inhibitor.
CSN33100 N-(3-Cyano-1H-indol-7-yl)benzene-1,4-disulfonamide 444579-59-3 Indisulam analog 4, as molecular glue, is especially effective and improves the half maximal effective concentration (EC50) to 1.21 µM in recruiting RBM39 to the DCAF15–DDB1–DDA1 complex.
CSN26246 HAMNO 138736-73-9 HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. It has shown to significantly inhibits colony formation when combined with etoposide.
CSN23239 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one 118-00-3 Guanosine is a purine nucleoside.
CSN29504 Gemcitabine monophosphate 116371-67-6 Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
CSN22052 Deoxypseudouridine 39967-60-7 Deoxypseudouridine is a nucleotide analog.
CSN16684 2,2'-((3S,6S,9R,15S,18R,21S,24S,30S,31R)-30-((S)-2-((R)-4-Amino-2-((S)-2-decanamido-3-(1H-indol-3-yl)propanamido)-4-oxobutanamido)-3-carboxypropanamido)-3-(2-(2-aminophenyl)-2-oxoethyl)-24-(3-aminopropyl)-6-((R)-1-carboxypropan-2-yl)-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontane-15,21-diyl)diacetic acid 103060-53-3 Daptomycin is a lipopeptide antimicrobial agent with activity against Gram-positive organisms, including multi-resistant strains.
CSN24877 Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogentriphosphate 36051-68-0 Cytidine 5'-triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases.
CSN25243 CMLD-2 958843-91-9 CMLD-2 competitively binds to Hu antigen R with Ki value of 350nM and disrupts the interaction of HuR and ARE (adenine- and uridine-rich element) of target mRNAs.
CSN27392 3,5-Bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylic acid 19350-66-4 AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity.
CSN32946 COH-4 1190932-36-5 Apoptosis Inducers; RRM2 Expression Inhibitors
CSN32948 COH-20 1190932-37-6 Apoptosis Inducers; RRM2 Expression Inhibitors
CSN32947 COH1 20217-22-5 Apoptosis Inducers; RRM2 Expression Inhibitors
CSN18264 A2AR-agonist-1 41552-95-8 A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1.
CSN23866 8-Chloroadenosine 34408-14-5 8-Chloroadenosine is a cytotoxic nucleoside analog, it can inhibit RNA synthesis.
CSN25518 6-Thioguanosine 85-31-4 6-thioguanosine is photosensitive molecule that photocrosslinks to both proteins and nucleic acids.
CSN12836 7H-Purine-6-thiol hydrate 6112-76-1 6-Mercaptopurine Monohydrate inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro.
CSN16373 6-Mercaptopurine 50-44-2 6-Mercaptopurine inhibits the de novo purine synthesis through interference with DNA and RNA synthesis, it's an immunosuppressive and antileukemic drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro.
CSN24938 5-Methylcytosine 554-01-8 5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription.
CSN24883 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one 838-07-3 5-Methyl-2'-deoxycytidine (5-Me-dC) is a minor component found in most eukaryotic DNA.
CSN25531 4-Amino-5-bromo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 3066-86-2 5-Bromocytidine is a bromine substituted nucleoside.Its β-isomer derivative is a potent anti-HIV agent.
CSN27391 3,4-Dihydroxybenzylamine HBr 16290-26-9 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits DNA polymerase activity in melanoma cells. 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.
CSN18758 2'-Deoxycytidine hydrochloride 3992-42-5 2'-Deoxyguanosine HCl is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose.
CSN25519 6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-purine-8(9H)-thione 3001-45-4
CSN27830 NSAH 1099592-35-4
CSN32745 SCR130 2377858-38-1
CSN62426 Nusinersen 1258984-36-9
CSN63477 NVS-SM2 1562333-92-9
CSN85479 Branaplam HCl 1562338-39-9
CSN107520 Trimidox 95933-74-7
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