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DNA/RNA Synthesis
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN21893 | Vidarabine Monohydrate | 24356-66-9 | Vidarabine is an antiviral drug which is active against herpes simplex and varicella zoster viruses. |
| CSN23525 | Uridine-5'-triphosphoric acid trisodium salt | 19817-92-6 | Uridine-5'-triphosphoric acid trisodium salt is a pyrimidine nucleoside triphosphate, a substrate for the synthesis of RNA during transcription. |
| CSN20001 | Thiolutin | 87-11-6 | Thiolutin is an antibiotic which inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Thiolutin also suppresses tumor cell-induced angiogenesis. |
| CSN20038 | Thailanstatin A | 1426953-21-0 | Thailanstatin A is a spliceosome inhibitor that disrupts cancer by inhibiting DNA-editing machinery. |
| CSN19246 | Saccharin 1-methylimidazole | 482333-74-4 | Saccharin 1-methylimidazole is a DNA/RNA synthesis activator. |
| CSN25509 | 2'-Deoxy-2'-fluorouridine | 784-71-4 | RNA that was modified with 2'-deoxy-2'-fluorouridine yielded full length HIV-1 reverse transcription products, with complete fidelity in transcription. RNA analogue, FF, containing two molecules of 2'-deoxy-2'-alpha-fluorouridine in place of uridine efficiently inhibited the RNase L-catalyzed RNA cleavage reaction. |
| CSN19074 | RK-33 | 1070773-09-9 | RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells. |
| CSN21373 | Risdiplam | 1825352-65-5 | Risdiplam is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels. |
| CSN21413 | RG7800 HCl | N/A | RG7800 HCl is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; has the potential to treat spinal muscular atrophy. |
| CSN19260 | Pyridostatin TFA | 1472611-44-1 | Pyridostatin Trifluoroacetate stabilizes and binds G-quadruplexe with Kd of 490 nM (cell-free assay), which targets the proto-oncogene c-kit, K-ras and Bcl-2. |
| CSN19455 | Panaxadiol | 19666-76-3 | Panaxadiol, a natural product isolated and purified from the roots of Panax ginseng C. |
| CSN21761 | Nimustine HCl | 55661-38-6 | Nimustine HCl is a nitrosourea alkylating agent with antineoplastic activity. |
| CSN20483 | Plicamycin | 18378-89-7 | Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action, and inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells. |
| CSN19728 | Lss-11 | 1392014-36-6 | LSS-11 bound to DNA in vitro and in cell mainly by minor groove binding and significantly increased the stability of DNA, which could be fundamental for the biological activities of LSS-11. It can inhibit multiple DNA-associated processes and tumor growth. |
| CSN25484 | L-Guanosine | 26578-09-6 | Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. L-Guanosine is the L configuration of Guanosine. |
| CSN20338 | FEN1-IN-3 | 2109805-87-8 | FEN1 inhibitor C3 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage. |
| CSN20337 | FEN1-IN-4 | 1995893-58-7 | FEN1 inhibitor C2 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage. |
| CSN20336 | FEN1-IN-1 | 824983-91-7 | FEN1 inhibitor C1 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage. |
| CSN14493 | Euscaphic acid | 53155-25-2 | Euscaphic acid, a natural product isolated and purified from the dried fruit of Ziziphus jujuba, with anti-diabetic and anti-inflammatory activities, induces death by activation of caspase-3, dependent apoptotic pathway, and inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations. |
| CSN20378 | Dfp-11207 | 1296177-16-6 | DFP-11207 is a n orally available thymidylate synthase (TS) inhibitor with potential antineoplastic activity. |
| CSN19369 | 4-Amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | 147-94-4 | Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. |
| CSN19249 | CeMMEC13 | 1790895-25-8 | CeMMEC13 inhibits the second bromodomain of TAF1 selectively with IC50 of 2.1 µM. |
| CSN19248 | CeMMEC1 HCl | 2095432-53-2 | CeMMEC1 HCl is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM). |
| CSN20655 | CBL0137 | 1197996-80-7 | CBL-0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. |
| CSN20324 | Brr2-IN-3 | 2104030-82-0 | Brr2 inhibitor C9 is an allosteric inhibitor targeting the spliceosomal RNA helicase Brr2, which implicated in autosomal-dominant retinitis pigmentosa, a group of progressive retinal degenerative disorders. |
| CSN10073 | Blasticidin S HCl | 3513-03-9 | Blasticidin S inhibits protein synthesis by acting on the step of peptide transfer from peptidyl-sRNA to incoming aminoacyl-sRNA. |
| CSN20798 | (E)-3-Benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one | 1290541-46-6 | B02 is a RAD51 inhibitor with IC50 of 27.4 μM for human RAD51. |
| CSN19282 | APE1 Inhibitor C10 | 1227098-30-7 | APE1 inhibitor C10 is a small molecular inhibitor which has a potent in treating Kaposi's sarcoma-associated herpesvirus (KSHV). |
| CSN19367 | 7H-Purin-6-amine hemisulfate | 321-30-2 | Adenine Sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with varieties of biochemistry roles. |
| CSN23577 | Purin-6-amine | 73-24-5 | Adenine is a purine derivative and a nucleobase with varieties of biochemistry roles. |
| CSN23390 | Adenine hydrochloride | 2922-28-3 | Adenine HCl is a purine derivative and a nucleobase with a variety of biochemistry roles. |
| CSN25488 | 8-Bromoguanosine | 4016-63-1 | 8-Bromoguanosine is a brominated derivative of guanosine. |
| CSN23335 | 5-Methoxyflavone | 42079-78-7 | 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors. |
| CSN25506 | 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidin-2(1H)-one | 611-53-0 | 5-Iododeoxycytidine is used in the construction of DNA oligomers. |
| CSN25526 | 5-Iodocytidine | 1147-23-5 | 5-Iodocytidine is used for research in the field of nucleic acids and nucleic acid-protein interactions. |
| CSN25507 | 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione | 316-46-1 | 5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity and cytotoxic activity. 5-fluorouridine inhibits rRNA synthesis of human colon carcinoma cells. 5-Fluorouridine exhibits cytotoxic effect on growth of L1210 cells with an IC50 of 2 nM. 5-Fluorouridine triphosphate acted as a potent competitive inhibitor of VPg uridylylation, the initial step of viral replication. |
| CSN19496 | 5-Fluoropyrimidine-2,4(1H,3H)-dione | 51-21-8 | 5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
| CSN25530 | 5-Fluorocytidine | 2341-22-2 | 5-Fluorocytidine could replace cytidine and be incorporated into cellular RNAs or tRNAs.The bacterial enzyme cytosine deaminase has been used as a negative selection marker system. Cells that express cytosine deaminase convert 5-fluorocytosine to the toxic compound 5-fluorouracil, and transformed seedlings can thus be identified using medium containing 5-fluorocytosine. |
| CSN25480 | 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethynylpyrimidine-2,4(1H,3H)-dione | 69075-42-9 | 5-Ethynyluridine is used to help detect RNA synthesis in cells by its biosynthetic incorporation into newly transcribed RNA. Once fed to cells, it is incorporated during active RNA synthesis and can then be detected using a copper-catalyzed click reaction with fluorescent dyes. The cells can then be analysed by fluorescence imaging, flow cytometry or high content imaging analysis. |
| CSN25508 | 5-Bromouridine | 957-75-5 | 5-Bromouridine is used to label RNA in measurement of RNA production. |
| CSN25483 | 3'-O-Acetylthymidine | 21090-30-2 | 3'-O-Acetylthymidine is a useful modified nucleoside. |
| CSN25481 | 1-((2R,4S,5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione | 40733-27-5 | 3'-O-(TBDMS)Thymidine is a useful modified nucleoside. |
| CSN25486 | 2'-O-Methylguanosine | 2140-71-8 | 2'-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine as a substrate. |
| CSN25490 | 2′-O-(2-Methoxyethyl)guanosine | 473278-54-5 | 2'-O-(2-Methoxyethyl)-guanosine is a guanosine derivative as building blocks for cross-linking oligonucleotides. |
| CSN23622 | 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 951-78-0 | 2'-Deoxyuridine is frequently halogenated to create thymidine analogues which is useful in studies of DNA synthesis and degradation mechanisms. |
| CSN23444 | 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | 951-77-9 | 2'-Deoxycytidine, a deoxyribonucleoside, can be used to synthesis DNA. It also exhibits inhibition of growth of cholangiocarcinoma cells. |
| CSN25516 | 2'-Deoxyadenosine | 958-09-8 | 2'-Deoxyadenosine is a nucleoside adenosine derivative, pairing with deoxythymidine (T) in double-stranded DNA. |
| CSN25491 | 2',3',5'-Tri-O-acetylinosine | 3181-38-2 | 2',3',5'-Tri-O-acetylinosine is an intermediate used for the synthesis of 6-substituted purine ribosides. |
| CSN25487 | 2'-Deoxy-L-guanosine | 22837-44-1 | |
| CSN25489 | N-Isobutyrylguanosine | 64350-24-9 |
