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Dopamine Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12144 | N,N-Dimethyl-3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propan-1-amine hydrochloride | 1098-60-8 | Triflupromazine HCl, an antipsychotic, can function as a blocker of dopamine D2 receptor and dopamine D3 receptor in brain. It is used to treat dyskinesia and alcohol withdrawal syndrome. |
| CSN12143 | Trifluoperazine | 117-89-5 | Trifluoperazine is a typical antipsychotic of the phenothiazine chemical class. |
| CSN12088 | Tiapride HCl | 51012-33-0 | Tiapride HCl is a drug that selectively blocks D2 and D3 dopamine receptors in the brain. |
| CSN16278 | 2,3,9,10-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline | 2934-97-6 | Tetrahydropalmatine is an isoquinoline alkaloid mainly found in the genus Corydalis with analgesic effects. It antagonizes dopamine D1, and D2 receptors as well as actions at dopamine D3, alpha adrenergic and serotonin receptors, with Ki values of 124 nM and 388 nM for D1 and D2 dopamine receptors, respectively. |
| CSN12068 | Tetrahydroberberine,THB | 522-97-4 | Tetrahydroberberine is an isoquinoline alkaloid isolated and purified from the barks of Phellodendron chinense Schneid. It has micromolar affinity for dopamine D(2) (pK (i) = 6.08) and 5-HT(1A) (pK (i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors(5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK (i) < 5.00). |
| CSN12026 | 6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine | 101626-70-4 | Talipexole is a dopamine agonist that has been proposed as an antiparkinsonian agent. |
| CSN12723 | Sumanirole maleate | 179386-44-8 | Sumanirole maleate is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. |
| CSN16178 | Sulpiride | 15676-16-1 | Sulpiride is a typical antipsychotic drug that binds to dopamine D2 receptor. Sulpiride is an effective treatment for schizophrenia and depressive disorder. |
| CSN17500 | ST-836 | 1148156-63-1 | ST-836 is a dopamine receptor ligand and an antiparkinsonian agent. |
| CSN17819 | ST-836 hydrochloride | 1415564-68-9 | ST-836 HCl is a dopamine receptor ligand which act as an antiparkinsonian agent. |
| CSN13576 | SKF 38393 HCl | 62717-42-4 | SKF-38393 HCl is an agonist of dopamine D1 receptor (the IC50 value is 110 nM). It has anorectic and stimulant effects. |
| CSN18110 | SB269652 | 215802-15-6 | SB-269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R) and a chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology. |
| CSN11868 | (S)-2,3,9,10-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline | 483-14-7 | Rotundine is antagonist for domapmine D1 receptor(Ki = 124 nM) and has a lower binding activity of domapmine D2 receptor and domapmine D3 receptor. It can also inhibit 5-HT1A (Ki = 340 nM). |
| CSN11867 | (S)-6-(Propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol | 99755-59-6 | Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Ki of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor. |
| CSN13718 | Rotigotine HCl | 125572-93-2 | Rotigotine HCl is an agonist of dopamine D2 receptor and dopamine D3 receptor with Ki of 13 and 0.71 nM respectively. |
| CSN13078 | 4-(2-(Dipropylamino)ethyl)indolin-2-one hydrochloride | 91374-20-8 | Ropinirole HCl selectively inhibit dopamine D2 receptor with Ki of 29 nM. It is used for the treatment of spontaneous parkinson's disease. |
| CSN17398 | (Rac)-Rotigotine HCl | 102120-99-0 | rac-Rotigotine HCl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM. |
| CSN11816 | Quinagolide HCl | 94424-50-7 | Quinagolide HCl is a selective dopamine D2 receptor agonist, also is a prolactin inhibitor. |
| CSN11783 | Promazine HCl | 53-60-1 | Promazine HCl is a D2 dopamine receptor antagonist, belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia. |
| CSN16556 | Prochlorperazine Dimaleate | 84-02-6 | Prochlorperazine dimaleate is an antagonist of dopamine (D2) receptor with Ki value of 4.7 nM. |
| CSN12476 | (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine | 104632-26-0 | Pramipexole is an agonist of dopamine receptors D2, D3, and D4 (Ki = 3.9, 2.2, 0.5, and 5.1 nM respectively) and it is indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS). |
| CSN13669 | (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride hydrate | 191217-81-9 | Pramipexole 2HClis a non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease. |
| CSN11760 | (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride | 104632-25-9 | Pramipexole 2HCl is an dopamine agonist and can inhibit multiple dopamine receptors including dopamine D2S receptor, dopamine D2L receptor, dopamine D3 receptor, and dopamine D4 receptor with respectively Ki values of 3.9, 2.2, 0.5 and 5.1 nM. |
| CSN11693 | Phenothiazine | 92-84-2 | Phenothiazine, a dopamine2 (D2) receptor antagonist, could reduce the expression of dopamine in the brain. |
| CSN11685 | Perphenazine | 58-39-9 | Perphenazine is an inhibitor of 5-HT2A receptor(5-HT2A), alpha-1A adrenergic receptor (α1A), dopamine D2 receptor/dopamine D3 receptor, D2L receptor, and Histamine H1 receptor ( Kis = 5.6, 10, 0.765/0.13, 3.4, and 8 nM respectively). It is commonly used as a typical antipsychotic drug. |
| CSN13887 | (4aR,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochromeno[4,3-b][1,4]oxazin-9-ol hydrochloride | 112960-16-4 | PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. |
| CSN11571 | Nomifensine maleate | 32795-47-4 | Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder. |
| CSN11570 | Nomifensine | 24526-64-5 | Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters. |
| CSN11546 | (S)-2-((2S,3S)-2-((S)-2-((S)-1-((2S,3S)-2-((S)-2,6-Diaminohexanamido)-3-methylpentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid | 92169-45-4 | Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. |
| CSN17271 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine HCl | 23007-85-4 | MPTP HCl is a neurotoxin that causes symptoms similar to parkinson's disease by destroying dopamine-producing nerve cells in the substantia nigra. It is widely used in the study of various animal models of Parkinson's disease. |
| CSN11461 | Molindone HCl | 15622-65-8 | Molindone HCl, the salt form of molindone which is a dopamine receptor antagonist, can be used in the treatment of schizophrenia and act as a therapeutic antipsychotic. |
| CSN17905 | 4-(4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one hydrochloride | 1511-16-6 | Haloperidol HCl blocks dopamine receptors in in the treatment of schizophrenia, acute psychosis, and delirium. |
| CSN15992 | cis-(Z)-Flupentixol dihydrochloride | 51529-01-2 | Flupenthixol 2HCl, a typical antipsychotic drug, is non-selective antagonist of dopamine D1-5 receptors as well as 5-HT2A. It is also known as flupenthixol. |
| CSN17027 | Fenoldopam | 67227-56-9 | Fenoldopam is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist. |
| CSN12899 | (R)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine | 104632-28-2 | Dexpramipexole is a neuroprotective agent and weak non-ergoline dopamine agonist. |
| CSN17422 | Dexpramipexole 2HCl | 104632-27-1 | Dexpramipexole 2HCl is the HCl form of Dexpramipexole which is a non-ergoline dopamine agonist for treatment of parkinson's disease and restless leg syndrome.Dexpramipexole is an (R)-(+) optical enantiomer of pramipexole. |
| CSN16971 | Cariprazine HCl | 1083076-69-0 | Cariprazine HCl is an antipsychotic drug candidate that exhibits high selectivity and affinity to dopamine D3 (Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin 5-HT(1A) receptors. |
| CSN16030 | Cariprazine | 839712-12-8 | Cariprazine exhibits high selectivity and affinity to dopamine D3 receptor (Ki=0.09 nM) and lower binding activity to dopamine D2 receptor and 5-HT(1A) with Ki of 0.5 nM and 2.6 nM repectively. It has been used as antipsychotics in the treatment of schizophrenia and bipolar disorder. |
| CSN16788 | Cabergoline | 81409-90-7 | Cabergoline, an ergot derivative, is a potent dopamine receptor agonist on D2 receptors. |
| CSN12577 | Azaperone | 1649-18-9 | Azaperone functions as a dopamine antagonist that can bind to D1 and D2 receptors. It has the characteristics of antihistamines and anticholinergics. |
| CSC13887 | PD128907 HCl | 112960-16-4 |
