Deubiquitinase | Cell Cycle|Ubiquitin| CSNpharm

DUB

DUB
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货号	产品名	CAS号	信息
CSN19439	TCID	30675-13-9	TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.
CSN16328	SJB2-043	63388-44-3	SJB2-043 is an inhibitor of ubiquitin-specific protease 1 (USP1) and it is one of derivatives of C527.
CSN13807	PR-619	2645-32-1	PR-619 is a broad-spectrum and reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM and it was developed for chemotherapy.
CSN18381	LDN-57444	668467-91-2	LDN-57444 is a reversible inhibitor of UCHL1 with IC50 of 0.88 μM (Ki = 0.4 μM) and its selectivity is better than UCH-L3 (IC50 = 25 μM).
CSN21377	C527	192718-06-2	C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
CSN15845	b-AP15	1009817-63-3	b-AP15 is an inhibitor of the ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) and ubiquitin-specific-processing protease 14 (USP14). In purified 19S proteasomes, b-AP15 can inhibit DUB activity with an IC50 of 2.1 μM.
CSN10355	Auranofin	34031-32-8	Auranofin is a proteasomal deubiquitinase inhibitor with inhibition of the proteasome-associated deubiquitinases (DUBs) UCHL5 and USP14 rather than 20S proteasome, which is required for Auranofin-induced cytotoxicity. It selectively inhibits tumor growth in vivo and induces cytotoxicity in cancer cells from acute myeloid leukemia patients and by blocking NF-κB activation, Auranofin can attenuats the cardiac hypertrophy.