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DUB

DUB

货号 产品名 CAS号 信息
CSN25613 USP25/28 inhibitor AZ1 2165322-94-9 USP25/28 inhibitor AZ1 is a potent, selective and noncompetitive inhiibitor of both USP25 and USP28 with IC50 values of 0.7μM and 0.6μM, respectively.
CSN19439 TCID 30675-13-9 TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.
CSN16328 SJB2-043 63388-44-3 SJB2-043 is an inhibitor of ubiquitin-specific protease 1 (USP1) and it is one of derivatives of C527.
CSN13807 PR-619 2645-32-1 PR-619 is a broad-spectrum and reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM and it was developed for chemotherapy.
CSN18381 LDN-57444 668467-91-2 LDN-57444 is a reversible inhibitor of UCHL1 with IC50 of 0.88 μM (Ki = 0.4 μM) and its selectivity is better than UCH-L3 (IC50 = 25 μM).
CSN15814 IU1 314245-33-5 IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT.
CSN21377 C527 192718-06-2 C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
CSN15845 b-AP15 1009817-63-3 b-AP15 is an inhibitor of the ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) and ubiquitin-specific-processing protease 14 (USP14). In purified 19S proteasomes, b-AP15 can inhibit DUB activity with an IC50 of 2.1 μM.
CSN10355 Auranofin 34031-32-8 Auranofin is a proteasomal deubiquitinase inhibitor with inhibition of the proteasome-associated deubiquitinases (DUBs) UCHL5 and USP14 rather than 20S proteasome, which is required for Auranofin-induced cytotoxicity. It selectively inhibits tumor growth in vivo and induces cytotoxicity in cancer cells from acute myeloid leukemia patients and by blocking NF-κB activation, Auranofin can attenuats the cardiac hypertrophy.
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