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DUB
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17621 | USP7-USP47 Inhibitor | 1247825-37-1 | USP7-USP47 inhibitor is a potent and dual inhibitor of USP7/USP47 with IC50s of 0.42 μM (USP7) and 1.0 μM (USP47). |
| CSN19439 | TCID | 30675-13-9 | TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. |
| CSN16328 | SJB2-043 | 63388-44-3 | SJB2-043 is an inhibitor of ubiquitin-specific protease 1 (USP1) and it is one of derivatives of C527. |
| CSN13807 | PR-619 | 2645-32-1 | PR-619 is a broad-spectrum and reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM and it was developed for chemotherapy. |
| CSN13634 | P22077 | 1247819-59-5 | P22077 is an inhibitor of ubiquitin specific protease USP7 (EC50 = 8.6 μM). P22077 also inhibits the deubiquitinase USP47. |
| CSN16620 | P005091 | 882257-11-6 | P005091 acts as a selective inhibitor of ubiquitin-specific protease 7 (USP7) and USP47 with the EC50s of 4.2 μM and 4.3 μM respectively. |
| CSN18920 | ML364 | 1991986-30-1 | ML364 is an USP2 inhibitor. |
| CSN15929 | ML323 | 1572414-83-5 | ML323 exhibits reversible inhibition of USP1-UAF1 with IC50 of 76 nM and it also inhibits deneddylase and deSUMOylase. |
| CSN18381 | LDN-57444 | 668467-91-2 | LDN-57444 is a reversible inhibitor of UCHL1 with IC50 of 0.88 μM (Ki = 0.4 μM) and its selectivity is better than UCH-L3 (IC50 = 25 μM). |
| CSN15814 | IU1 | 314245-33-5 | IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. |
| CSN21377 | C527 | 192718-06-2 | C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM). |
| CSN15845 | b-AP15 | 1009817-63-3 | b-AP15 is an inhibitor of the ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) and ubiquitin-specific-processing protease 14 (USP14). In purified 19S proteasomes, b-AP15 can inhibit DUB activity with an IC50 of 2.1 μM. |
| CSN10355 | Auranofin | 34031-32-8 | Auranofin is a proteasomal deubiquitinase inhibitor with inhibition of the proteasome-associated deubiquitinases (DUBs) UCHL5 and USP14 rather than 20S proteasome, which is required for Auranofin-induced cytotoxicity. It selectively inhibits tumor growth in vivo and induces cytotoxicity in cancer cells from acute myeloid leukemia patients and by blocking NF-κB activation, Auranofin can attenuats the cardiac hypertrophy. |
