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DUB

DUB

货号 产品名 CAS号 信息
CSN13933 VLX1570 1431280-51-1 VLX1570 is a deubiquitinylating enzyme DUB competitive inhibitor with an IC50 of approximately 10 μM in vitro and shows coinhibition of the deubiquitinating enzymes, like USP14 and UCHL5.
CSN17621 USP7/USP47 inhibitor 1247825-37-1 USP7-USP47 inhibitor is a potent and dual inhibitor of USP7/USP47 with IC50s of 0.42 μM (USP7) and 1.0 μM (USP47).
CSN17772 USP7-IN-1 1381291-36-6 USP7-IN-1 is a selective and reversible inhibitor of USP7 with IC50 of 33 μM, showing less or no inhibition on USP5, USP8, Uch-L1, Uch-L3 and Caspase (IC50> 200 μM). For HCT116 cell, the viability GI50 is 67 μM.
CSN25613 USP25/28 inhibitor AZ1 2165322-94-9 USP25/28 inhibitor AZ1 is a potent, selective and noncompetitive inhiibitor of both USP25 and USP28 with IC50 values of 0.7μM and 0.6μM, respectively.
CSN19439 TCID 30675-13-9 TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.
CSN18929 SJB3-019A 2070015-29-9 SJB3-019A is a potent USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM.
CSN16328 SJB2-043 63388-44-3 SJB2-043 is an inhibitor of ubiquitin-specific protease 1 (USP1) and it is one of derivatives of C527.
CSN26164 RA-9   919091-63-7 RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. Treatment with RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors。
CSN13807 PR-619 2645-32-1 PR-619 is a broad-spectrum and reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM and it was developed for chemotherapy.
CSN13634 P 22077 1247819-59-5 P22077 is an inhibitor of ubiquitin specific protease USP7 (EC50 = 8.6 μM). P22077 also inhibits the deubiquitinase USP47.
CSN16620 P005091 882257-11-6 P005091 acts as a selective inhibitor of ubiquitin-specific protease 7 (USP7) and USP47 with the EC50s of 4.2 μM and 4.3 μM respectively.
CSN18918 NSC632839 157654-67-6 NSC 632839 HCl is an nonselective inhibitor of isopeptidase and inhibits various proteins including USP2, USP7, and SENP2 (EC50 = 45 ± 4 μM, 37 ± 1 μM, and 9.8 ± 1.8 μM, respectively).
CSN18920 ML364 1991986-30-1 ML364 is an USP2 inhibitor.
CSN15929 ML-323 1572414-83-5 ML323 exhibits reversible inhibition of USP1-UAF1 with IC50 of 76 nM and it also inhibits deneddylase and deSUMOylase.
CSN18381 LDN-57444 668467-91-2 LDN-57444 is a reversible inhibitor of UCHL1 with IC50 of 0.88 μM (Ki = 0.4 μM) and its selectivity is better than UCH-L3 (IC50 = 25 μM).
CSN24487 IU1-47 670270-31-2 IU1-47 is a potent USP14 inhibitor with IC50 value of 60nM.
CSN15814 IU1 314245-33-5 IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT.
CSN22847 HBX 41108 924296-39-9 HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity with IC50 of 424 nM.
CSN17834 HBX 19818 1426944-49-1 HBX 19818 is a selective USP7 inhibitor with IC50 of 28.1 μM .
CSN23352 GNE-6776 2009273-71-4 GNE-6776 is selective ubiquitin specific protease-7 (USP7) inhibitor with IC50 of 1.34 μM through binding to acidic amino acid residues.
CSN23348 GNE-6640 2009273-67-8 GNE-6640 is a selective inhibitor of ubiquitin specific protease-7 (USP7) (IC50 = 0.75 μM) that can induce tumor cell death and enhance the effect of chemotherapy drugs.
CSN22406 FT827 1959537-86-0 FT827 is a selective and covalent ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 52 nM.
CSN21254 FT671 1959551-26-8 FT671 is a potent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM.
CSN25574 EOAI3402143 1699750-95-2 EOAI3402143 is a deubiquitinase (DUB) inhibitor, which dose-dependently inhibits Usp9x/Usp24 and Usp5.
CSN18587 DUB-IN-3 924296-17-3 DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 3.1 μM for USP8, showing > 30 fold selectivity over USP7 (IC50 > 100 μM).
CSN18589 DUB-IN-2 924296-19-5 DUBs-IN-2 is a potent deubiquitinase enzyme inhibitor with IC50s of 7.2 μM/0.93 μM for USP7/USP8 respectively.
CSN18588 DUB-IN-1 924296-18-4 DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 μM/0.71 μM for USP7/USP8 respectively.
CSN21377 C527 192718-06-2 C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
CSN15845 b-AP15 1009817-63-3 b-AP15 is an inhibitor of the ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) and ubiquitin-specific-processing protease 14 (USP14). In purified 19S proteasomes, b-AP15 can inhibit DUB activity with an IC50 of 2.1 μM.
CSN10355 Auranofin 34031-32-8 Auranofin is a proteasomal deubiquitinase inhibitor with inhibition of the proteasome-associated deubiquitinases (DUBs) UCHL5 and USP14 rather than 20S proteasome, which is required for Auranofin-induced cytotoxicity. It selectively inhibits tumor growth in vivo and induces cytotoxicity in cancer cells from acute myeloid leukemia patients and by blocking NF-κB activation, Auranofin can attenuats the cardiac hypertrophy.
CSN39367 GSK2643943A 2449301-27-1
CSN39434 (R)-FT671 1959551-27-9
CSN38063 LDN-91946 439946-22-2
CSN39074 6RK73 1895050-66-4
CSN51364 IU1-248 2307472-03-1
CSN75088 (R)-3-(4-(Aminomethyl)phenyl)-6-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-2-methyl-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 2196243-57-7
CSN75189 KSQ-4279 2446480-97-1
CSN108095 4-(4-Isopropylphenyl)-4-oxobutanoic acid 6947-81-5
CSN107097 1-(4-Nitro-5-(phenylthio)thiophen-2-yl)ethanone 90680-28-7
CSN105443 N-Cyclopropyl-N-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine 1356074-25-3
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