400-920-2911 sales@csnpharm.cn
DUB
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN13933 | VLX1570 | 1431280-51-1 | VLX1570 is a deubiquitinylating enzyme DUB competitive inhibitor with an IC50 of approximately 10 μM in vitro and shows coinhibition of the deubiquitinating enzymes, like USP14 and UCHL5. |
CSN17621 | USP7/USP47 inhibitor | 1247825-37-1 | USP7-USP47 inhibitor is a potent and dual inhibitor of USP7/USP47 with IC50s of 0.42 μM (USP7) and 1.0 μM (USP47). |
CSN17772 | USP7-IN-1 | 1381291-36-6 | USP7-IN-1 is a selective and reversible inhibitor of USP7 with IC50 of 33 μM, showing less or no inhibition on USP5, USP8, Uch-L1, Uch-L3 and Caspase (IC50> 200 μM). For HCT116 cell, the viability GI50 is 67 μM. |
CSN25613 | USP25/28 inhibitor AZ1 | 2165322-94-9 | USP25/28 inhibitor AZ1 is a potent, selective and noncompetitive inhiibitor of both USP25 and USP28 with IC50 values of 0.7μM and 0.6μM, respectively. |
CSN19439 | TCID | 30675-13-9 | TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. |
CSN18929 | SJB3-019A | 2070015-29-9 | SJB3-019A is a potent USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM. |
CSN16328 | SJB2-043 | 63388-44-3 | SJB2-043 is an inhibitor of ubiquitin-specific protease 1 (USP1) and it is one of derivatives of C527. |
CSN26164 | RA-9 | 919091-63-7 | RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. Treatment with RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors。 |
CSN13807 | PR-619 | 2645-32-1 | PR-619 is a broad-spectrum and reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM and it was developed for chemotherapy. |
CSN13634 | P 22077 | 1247819-59-5 | P22077 is an inhibitor of ubiquitin specific protease USP7 (EC50 = 8.6 μM). P22077 also inhibits the deubiquitinase USP47. |
CSN16620 | P005091 | 882257-11-6 | P005091 acts as a selective inhibitor of ubiquitin-specific protease 7 (USP7) and USP47 with the EC50s of 4.2 μM and 4.3 μM respectively. |
CSN18918 | NSC632839 | 157654-67-6 | NSC 632839 HCl is an nonselective inhibitor of isopeptidase and inhibits various proteins including USP2, USP7, and SENP2 (EC50 = 45 ± 4 μM, 37 ± 1 μM, and 9.8 ± 1.8 μM, respectively). |
CSN18920 | ML364 | 1991986-30-1 | ML364 is an USP2 inhibitor. |
CSN15929 | ML-323 | 1572414-83-5 | ML323 exhibits reversible inhibition of USP1-UAF1 with IC50 of 76 nM and it also inhibits deneddylase and deSUMOylase. |
CSN18381 | LDN-57444 | 668467-91-2 | LDN-57444 is a reversible inhibitor of UCHL1 with IC50 of 0.88 μM (Ki = 0.4 μM) and its selectivity is better than UCH-L3 (IC50 = 25 μM). |
CSN24487 | IU1-47 | 670270-31-2 | IU1-47 is a potent USP14 inhibitor with IC50 value of 60nM. |
CSN15814 | IU1 | 314245-33-5 | IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. |
CSN22847 | HBX 41108 | 924296-39-9 | HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity with IC50 of 424 nM. |
CSN17834 | HBX 19818 | 1426944-49-1 | HBX 19818 is a selective USP7 inhibitor with IC50 of 28.1 μM . |
CSN23352 | GNE-6776 | 2009273-71-4 | GNE-6776 is selective ubiquitin specific protease-7 (USP7) inhibitor with IC50 of 1.34 μM through binding to acidic amino acid residues. |
CSN23348 | GNE-6640 | 2009273-67-8 | GNE-6640 is a selective inhibitor of ubiquitin specific protease-7 (USP7) (IC50 = 0.75 μM) that can induce tumor cell death and enhance the effect of chemotherapy drugs. |
CSN22406 | FT827 | 1959537-86-0 | FT827 is a selective and covalent ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 52 nM. |
CSN21254 | FT671 | 1959551-26-8 | FT671 is a potent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM. |
CSN25574 | EOAI3402143 | 1699750-95-2 | EOAI3402143 is a deubiquitinase (DUB) inhibitor, which dose-dependently inhibits Usp9x/Usp24 and Usp5. |
CSN18587 | DUB-IN-3 | 924296-17-3 | DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 3.1 μM for USP8, showing > 30 fold selectivity over USP7 (IC50 > 100 μM). |
CSN18589 | DUB-IN-2 | 924296-19-5 | DUBs-IN-2 is a potent deubiquitinase enzyme inhibitor with IC50s of 7.2 μM/0.93 μM for USP7/USP8 respectively. |
CSN18588 | DUB-IN-1 | 924296-18-4 | DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 μM/0.71 μM for USP7/USP8 respectively. |
CSN21377 | C527 | 192718-06-2 | C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM). |
CSN15845 | b-AP15 | 1009817-63-3 | b-AP15 is an inhibitor of the ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) and ubiquitin-specific-processing protease 14 (USP14). In purified 19S proteasomes, b-AP15 can inhibit DUB activity with an IC50 of 2.1 μM. |
CSN10355 | Auranofin | 34031-32-8 | Auranofin is a proteasomal deubiquitinase inhibitor with inhibition of the proteasome-associated deubiquitinases (DUBs) UCHL5 and USP14 rather than 20S proteasome, which is required for Auranofin-induced cytotoxicity. It selectively inhibits tumor growth in vivo and induces cytotoxicity in cancer cells from acute myeloid leukemia patients and by blocking NF-κB activation, Auranofin can attenuats the cardiac hypertrophy. |
CSN39367 | GSK2643943A | 2449301-27-1 | |
CSN39434 | (R)-FT671 | 1959551-27-9 | |
CSN38063 | LDN-91946 | 439946-22-2 | |
CSN39074 | 6RK73 | 1895050-66-4 | |
CSN51364 | IU1-248 | 2307472-03-1 | |
CSN75088 | (R)-3-(4-(Aminomethyl)phenyl)-6-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-2-methyl-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | 2196243-57-7 | |
CSN75189 | KSQ-4279 | 2446480-97-1 | |
CSN108095 | 4-(4-Isopropylphenyl)-4-oxobutanoic acid | 6947-81-5 | |
CSN107097 | 1-(4-Nitro-5-(phenylthio)thiophen-2-yl)ethanone | 90680-28-7 | |
CSN105443 | N-Cyclopropyl-N-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine | 1356074-25-3 |