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E1/E2/E3 Enzyme

E1/E2/E3 Enzyme

货号 产品名 CAS号 信息
CSN27721 CRBN modulator-1 2407829-65-4 WUN29654 is a CRBN modulator with CRBN modulatory activity with IC50 value of 2.6μM, Ki value of 0.7μM and cell proliferation IC50 value of ~21.53μM.
CSN23792 VL285 1448188-57-5 VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.
CSN20606 VH-298 2097381-85-4 VH-298 is a highly affinity inhibitor of E3 ubiquitin ligase VHL inhibitor (Kd = 80-90 nM) which can block the interaction of VHL and HIF-α, thus initiating hypoxic response.
CSN22266 Thalidomide-O-amido-PEG4-C2-NH2 1957236-22-4 Thalidomide-O-amido-PEG4-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions.
CSN22269 Thalidomide-O-amido-PEG3-C2-NH2 1957236-20-2 Thalidomide-O-amido-PEG3-C2-Amine is a PROTAC block consist of Thalidomide and a linker with an Amine functional group for conjugation reactions.
CSN22270 Thalidomide-O-amido-PEG2-C2-NH2 1957235-74-3 Thalidomide-O-amido-PEG2-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions.
CSN22271 Thalidomide-O-amido-PEG-C2-NH2 2022182-59-6 Thalidomide-O-amido-PEG-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions.
CSN22268 Thalidomide-O-amido-C4-N3 2098488-36-7 Thalidomide-O-amido-C4-Azide is a PROTAC block consist of Thalidomide linked to alkyl with an Azide functional group for conjugation reactions.
CSN22274 Thalidomide-O-amido-C4-NH2 1799711-24-2 Thalidomide-O-amido-C4-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN22272 Thalidomide-O-amido-C3-NH2 2022182-57-4 Thalidomide-O-amido-C3-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN28415 Thalidomide-NH-C4-NH-Boc 2093388-52-2 Thalidomide-NH-C4-NH-Boc is a PROTAC block consist of Thalidomide with a Boc functional group for conjugation reactions.
CSN22519 Teslexivir 1075798-37-6 Teslexivir is a topical antiviral agent that is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an interaction that is a necessary step for Human Papilloma Virus (HPV) 6 and 11 DNA replication and thus viral production.
CSN21424 Thalidomide-O-COOH 1061605-21-7 TC E3 5031 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component.
CSN24144 Subasumstat 1858276-04-6 TAK-981 is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.
CSN21083 TAK-243 1450833-55-2 TAK-243, also known as MLN7243 and AOB87172, is a small molecule inhibitor of ubiquitin-activating enzyme (UAE), with potential antineoplastic activity.
CSN24085 Smurf1-IN-A01 1007647-73-5 Smurf1-IN-A01 is an inhibitor of negatively regulatory factor Smurf1 for promoting bone formation.
CSN25714 SMER3 67200-34-4 SMER 3 is a selective inhibitor of yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo.
CSN18272 Skp2 Inhibitor C1 432001-69-9 Skp2 inhibitor C1 is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.
CSN15975 PYR-41 418805-02-4 PYR-41 (50 μM) inhibits activity of ubiquitin-activating enzyme E1 by over 90%.
CSN22492 Boc-C1-PEG2-C4-Cl 1835705-53-7 PROTAC Linker 1 is a linker used to link the warhead and the E3 ligase ligand.
CSN23937 PROTAC BRD9 Degrader-1 2097971-01-0 PROTAC BRD9 Degrader-1 is a PROTAC targeting on BRD9, consist of a BRD9 bromodomain probe I-BRD9 as a warhead ligand and pomalidomide as the CRBN ligand.
CSN19741 PK 11195 85532-75-8 PK11195 is a 2‑Phenylindolylglyoxylyldipeptide Murine Double Minute2 (MDM2)/Translocator Protein (TSPO)/Human Constitutive Androstane Receptor (hCAR) Inhibitor, and is potentially useful for the Treatment of Gliomas.
CSN25713 N106 862974-25-2 N106 is an activator of SUMO-activating enzyme E1 ligase. It can increase SERCA2a SUMOylation and activity and enhance contractility in rat cardiomyocytes in vitro.
CSN20617 ML-792 1644342-14-2 ML-792 is a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays, which selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation.
CSN27723 MID-1   312608-54-1 MID-1 is a MG53-IRS-1 interaction disruptor. It abolished MG53-mediated IRS-1 ubiquitination and degradation, as well as sensitized insulin signaling and increased insulin-elicited glucose uptake with an elevated level of IRS-1 in C2C12 myotubes.
CSN20357 (S,R,S)-AHPC 1448297-52-6 MDK7526 is a ligand of Von Hippel–Lindau protein, that can be used for making proteolysis targeting chimeras (PROTACs).
CSN27287 LS-102   1456891-34-1 LS-102 is a selective inhibitor of E3 ubiquitin ligase synoviolin (Syvn1). LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment.
CSN22273 E3 Ligand-Linker Conjugate 4 2093388-45-3 Lenalidomide-C5-Amine is a PROTAC block consist of Lenalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN22267 E3 Ligand-Linker Conjugate 5 2093388-69-1 Lenalidomide-C4-Amine is a PROTAC block consist of Lenalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN22090 IACS-9571 1800477-30-8 IACS-9571 is a potent and selective inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.
CSN22427 VH032-PEG5-C6-Cl 1799506-06-1 HaloPROTAC 2 is a PROTAC block consist of VH032 and a linker with chlorine functional group for conjugation reactions.
CSN32744 MuRF1-IN-1 445222-91-3 EMBL is an inhibitor of MuRF1.
CSN28743 E3 ligase Ligand 9 87304-15-2 E3 ligase Ligand 9 is a Bestatin-based E3 ligase ligand.
CSN21237 (S,R,S)-AHPC TFA 1631137-51-3 E3 Ligase Ligand 6 is used for conjugation reactions of PROTAC, which can hijack VHL as the E3 ubiquitin ligase component.
CSN21420 Thalidomide-4-OH 5054-59-1 E3 ligase Ligand 2 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component.
CSN21252 (S,R,S)-AHPC-Me 1948273-02-6 E3 ligase Ligand 1A is a VH032 derivate for conjugation reactions of PROTAC, which can hijack VHL as the E3 ubiquitin ligase component.
CSN23876 COH000 1534358-79-6 COH000 is an irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) with IC50 of 0.2 μM for SUMOylation in vitro.
CSN27230 Mezigdomide 2259648-80-9 CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD). CC-92480 shows high affinity to cereblon, resulting in potent antimyeloma activity .
CSN22248 CC-885 1010100-07-8 CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity.
CSN64606 Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride 2245697-85-0
CSN28728 (S,S,S)-AHPC hydrochloride 2115897-23-7
CSN33243 tert-Butyl 4-(2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)piperazine-1-carboxylate 2229723-91-3
CSN43361 UbcH5c-IN-1 2123480-72-6
CSN61257 (2S,4S)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride 2376990-32-6
CSN74444 4-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid 2172819-72-4
CSN74512 10-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-10-oxodecanoic acid 2172819-77-9
CSN75632 EN106 757192-67-9
CSN91926 8-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-8-oxooctanoic acid 2172819-75-7
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