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E1/E2/E3 Enzyme

E1/E2/E3 Enzyme

货号 产品名 CAS号 信息
CSN23792 VL285 1448188-57-5 VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.
CSN20606 VH-298 2097381-85-4 VH-298 is a highly affinity inhibitor of E3 ubiquitin ligase VHL inhibitor (Kd = 80-90 nM) which can block the interaction of VHL and HIF-α, thus initiating hypoxic response.
CSN22266 E3 Ligand-Linker Conjugate 10 1957236-22-4 Thalidomide-O-amido-PEG4-C2-Amine is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions.
CSN22272 E3 Ligand-Linker Conjugate 6 2022182-57-4 Thalidomide-O-amido-C3-Amine is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions.
CSN24768 Thalidomide-linker 2 2245697-85-0 Thalidomide-linker 2 is a PROTAC block consist of Thalidomide and a linker with Amine functional group for conjugation reactions.
CSN21083 TAK-243 1450833-55-2 TAK-243, also known as MLN7243 and AOB87172, is a small molecule inhibitor of ubiquitin-activating enzyme (UAE), with potential antineoplastic activity.
CSN17260 SZL P1-41 222716-34-9 SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes.
CSN24085 Smurf1-IN-A01 1007647-73-5 Smurf1-IN-A01 is an inhibitor of negatively regulatory factor Smurf1 for promoting bone formation.
CSN25714 SMER 3 67200-34-4 SMER 3 is a selective inhibitor of yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo.
CSN18199 PRT4165 31083-55-3 PRT4165, an inhibitor of bim1 and ring1A, could block PRC1 (Polycomb-repressive complex 1)-mediated H2A ubiquitylation.
CSN22492 PROTAC Linker 1 1835705-53-7 PROTAC Linker 1 is a linker used to link the warhead and the E3 ligase ligand.
CSN19741 PK11195 85532-75-8 PK11195 is a 2‑Phenylindolylglyoxylyldipeptide Murine Double Minute2 (MDM2)/Translocator Protein (TSPO)/Human Constitutive Androstane Receptor (hCAR) Inhibitor, and is potentially useful for the Treatment of Gliomas.
CSN17303 NSC 697923 343351-67-7 NSC 697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.
CSN20357 MDK7526 1448297-52-6 MDK7526 is a ligand of Von Hippel–Lindau protein, that can be used for making proteolysis targeting chimeras (PROTACs).
CSN21420 E3 ligase Ligand 2 5054-59-1 E3 ligase Ligand 2 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component.
CSN21252 E3 Ligase Ligand 1A 1948273-02-6 E3 ligase Ligand 1A is a VH032 derivate for conjugation reactions of PROTAC, which can hijack VHL as the E3 ubiquitin ligase component.
CSN23876 COH000 1534358-79-6 COH000 is an irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) with IC50 of 0.2 μM for SUMOylation in vitro.
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