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EGFR/PROTAC

货号 产品名 CAS号 信息
CSN28533 SJF 1521 2230821-40-4 Selective EGFR PROTAC.
CSN28508 MS154 2550393-21-8 MS 154 is a potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant epidermal growth factor receptor (EGFR), comprising a cereblon-binding moiety joined by a linker to gefitinib. MS 154 decreases EGFR protein levels, inhibits downstream signaling in and inhibits proliferation of mutant EGFR-bearing lung cancer cells (DC50 values are 11 and 25 nM in HCC-827 and H3255 cells, respectively; Dmax > 95% at 50 nM), but not in WT-EGFR-bearing ovarian and lung cancer cells lines. It is bioavailable in mice following ip administration.
CSN28532 SJF 1528 2230821-38-0 Potent EGFR PROTAC®; also degrades HER2
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