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货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN28533 | SJF 1521 | 2230821-40-4 | Selective EGFR PROTAC. |
CSN28508 | MS154 | 2550393-21-8 | MS 154 is a potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant epidermal growth factor receptor (EGFR), comprising a cereblon-binding moiety joined by a linker to gefitinib. MS 154 decreases EGFR protein levels, inhibits downstream signaling in and inhibits proliferation of mutant EGFR-bearing lung cancer cells (DC50 values are 11 and 25 nM in HCC-827 and H3255 cells, respectively; Dmax > 95% at 50 nM), but not in WT-EGFR-bearing ovarian and lung cancer cells lines. It is bioavailable in mice following ip administration. |
CSN28532 | SJF 1528 | 2230821-38-0 | Potent EGFR PROTAC®; also degrades HER2 |
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