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EGFR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN20619 | Tyrphostin RG14620 | 136831-49-7 | Tyrphostin RG14620 is an EGFR inhibitor of tyrphostin family, which selectively reverses ABCG2-mediated multidrug resistance in cancer cell lines. |
| CSN21355 | AG 528 | 133550-49-9 | Tyrphostin is a potent inhibitor of EGFR protein tyrosine kinase. |
| CSN25719 | Tyrphostin B44, (+) enantiomer | 133550-37-5 | Tyrphostin B44, (+) enantiomer is an inhibitor of EGFR with IC50 of 0.86 μM. It is slightly less active than the (-) enantiomer. |
| CSN22616 | NSC-228155 | 113104-25-9 | NSC228155 can enhance the tyrosine phosphorylation of EGFR via binding to the dimerization domain II. It blocks KIX-KID interaction as well (IC50 = 0.36 μM). |
| CSN25720 | Methyl 2,5-dihydroxycinnamate | 63177-57-1 | Methyl 2,5-dihydroxycinnamate, the erbstatin analog, is an inhibitor of EGF receptor-associated tyrosine kinases. |
| CSN22878 | Lavendustin A | 125697-92-9 | Lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with IC50 of 11 nM. |
| CSN25434 | Khellin | 82-02-0 | Khellin, a naturally occurring furochromone, is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects. |
| CSN28785 | EGFR-IN-5 | 2225887-26-1 | EGFR-IN-5 is an inhibitor of EGFR with IC50 values of 10.4 nM, 1.1 nM, 34 nM and 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively. It could suppress EGFR phosphorylation in a dose-dependent manner in HCC827 cell line and significantly induce the apoptosis of HCC827 cells. |
| CSN25283 | CGP 52411 | 145915-58-8 | CGP 52411 inhibited the EGF-R protein-tyrosine kinase in vitro with high selectivity. In cells, CGP52411 selectively inhibited both ligand-induced EGF-R and p185c-erbB2 autophosphorylation and c-fos mRNA induction. |
| CSN10535 | Canertinib 2HCl | 289499-45-2 | Canertinib 2HCl, an irreversible quinazoline-based HER family tyrosine kinase inhibitor, inhibits EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM respectively. Phase II. |
| CSN25556 | BI-4020 | N/A | BI-4020 is a noncovalent, new-generation, wild-type EGFR sparing, macrocyclic tyrosine kinase inhibitor. |
| CSN21119 | AG-494 | 133550-35-3 | AG-494 is an inhibitor of EGFR with an IC50 value of 0.7 µM and it is inactive toward ErbB2, PDGFR and insulin receptor kinase. |
| CSN23735 | AG 99 | 122520-85-8 | AG 99 is an EGF receptor kinase inhibitor with IC50 of 10 µM in the human epidermoid carcinoma cell line A431. |
| CSN21882 | AG 555 | 133550-34-2 | AG 555 is an inhibitor of epidermal growth factor receptor (EGFR) with IC50 of 0.7 μM. |
| CSN24709 | AG-1557 | 189290-58-2 |
