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EGFR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN23885 | ZD-4190 | 413599-62-9 | ZD-4190 is an inhibitor of vascular endothelial cell growth factor receptor 2 (VEGFR2) and epidermal growth factor receptor (EGFR) signalling. |
| CSN25719 | Tyrphostin B44, (+) enantiomer | 133550-37-5 | Tyrphostin B44, (+) enantiomer is an inhibitor of EGFR with IC50 of 0.86 μM. It is slightly less active than the (-) enantiomer. |
| CSN28533 | SJF 1521 | 2230821-40-4 | Selective EGFR PROTAC. |
| CSN22616 | NSC-228155 | 113104-25-9 | NSC228155 can enhance the tyrosine phosphorylation of EGFR via binding to the dimerization domain II. It blocks KIX-KID interaction as well (IC50 = 0.36 μM). |
| CSN28508 | MS154 | 2550393-21-8 | MS 154 is a potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant epidermal growth factor receptor (EGFR), comprising a cereblon-binding moiety joined by a linker to gefitinib. MS 154 decreases EGFR protein levels, inhibits downstream signaling in and inhibits proliferation of mutant EGFR-bearing lung cancer cells (DC50 values are 11 and 25 nM in HCC-827 and H3255 cells, respectively; Dmax > 95% at 50 nM), but not in WT-EGFR-bearing ovarian and lung cancer cells lines. It is bioavailable in mice following ip administration. |
| CSN25720 | Methyl 2,5-dihydroxycinnamate | 63177-57-1 | Methyl 2,5-dihydroxycinnamate, the erbstatin analog, is an inhibitor of EGF receptor-associated tyrosine kinases. |
| CSN22878 | Lavendustin A | 125697-92-9 | Lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with IC50 of 11 nM. |
| CSN25434 | Khellin | 82-02-0 | Khellin, a naturally occurring furochromone, is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects. |
| CSN24696 | JND3229 | 2260886-64-2 | JND3229 is a new highly potent EGFR(C797S) inhibitor with IC50 values of 5.8nM, 30.5nM and 6.8nM for EGFR (L858R/T790M/C797S), EGFR (T790M, L858R) and EGFR, respectively. |
| CSN24731 | Idaein chloride | 27661-36-5 | Idaein chloride is a glycoside derivative of cyanidin, a potent inhibitor of EGFR, used in comparative analysis of anti-EGF activity in cancer cells. |
| CSN28785 | EGFR-IN-5 | 2225887-26-1 | EGFR-IN-5 is an inhibitor of EGFR with IC50 values of 10.4 nM, 1.1 nM, 34 nM and 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively. It could suppress EGFR phosphorylation in a dose-dependent manner in HCC827 cell line and significantly induce the apoptosis of HCC827 cells. |
| CSN25283 | CGP 52411 | 145915-58-8 | CGP 52411 inhibited the EGF-R protein-tyrosine kinase in vitro with high selectivity. In cells, CGP52411 selectively inhibited both ligand-induced EGF-R and p185c-erbB2 autophosphorylation and c-fos mRNA induction. |
| CSN10535 | Canertinib 2HCl | 289499-45-2 | Canertinib 2HCl, an irreversible quinazoline-based HER family tyrosine kinase inhibitor, inhibits EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM respectively. Phase II. |
| CSN25556 | BI-4020 | 2664214-60-0 | BI-4020 is a noncovalent, new-generation, wild-type EGFR sparing, macrocyclic tyrosine kinase inhibitor. |
| CSN24709 | AG-1557 | 189290-58-2 | AG1557 is a specific EGFR tyrosine kinase inhibitor with pIC50 value of 8.194. |
| CSN25386 | AG 1478 hydrochloride | 170449-18-0 | AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV). |
| CSN23735 | AG 99 | 122520-85-8 | AG 99 is an EGF receptor kinase inhibitor with IC50 of 10 µM in the human epidermoid carcinoma cell line A431. |
| CSN24707 | AG 556 | 133550-41-1 | AG 556 is an EGFR kinase inhibitor with IC50 value of 1.1μM, selective over ErbB2 (IC50 > 500 μM). |
| CSN28532 | SJF 1528 | 2230821-38-0 | Potent EGFR PROTAC®; also degrades HER2 |
