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EGFR

EGFR

货号 产品名 CAS号 信息
CSN23885 ZD-4190 413599-62-9 ZD-4190 is an inhibitor of vascular endothelial cell growth factor receptor 2 (VEGFR2) and epidermal growth factor receptor (EGFR) signalling.
CSN25719 Tyrphostin B44, (+) enantiomer 133550-37-5 Tyrphostin B44, (+) enantiomer is an inhibitor of EGFR with IC50 of 0.86 μM. It is slightly less active than the (-) enantiomer.
CSN28533 SJF 1521 2230821-40-4 Selective EGFR PROTAC.
CSN22616 NSC-228155 113104-25-9 NSC228155 can enhance the tyrosine phosphorylation of EGFR via binding to the dimerization domain II. It blocks KIX-KID interaction as well (IC50 = 0.36 μM).
CSN28508 MS154 2550393-21-8 MS 154 is a potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant epidermal growth factor receptor (EGFR), comprising a cereblon-binding moiety joined by a linker to gefitinib. MS 154 decreases EGFR protein levels, inhibits downstream signaling in and inhibits proliferation of mutant EGFR-bearing lung cancer cells (DC50 values are 11 and 25 nM in HCC-827 and H3255 cells, respectively; Dmax > 95% at 50 nM), but not in WT-EGFR-bearing ovarian and lung cancer cells lines. It is bioavailable in mice following ip administration.
CSN25720 Methyl 2,5-dihydroxycinnamate 63177-57-1 Methyl 2,5-dihydroxycinnamate, the erbstatin analog, is an inhibitor of EGF receptor-associated tyrosine kinases.
CSN22878 Lavendustin A 125697-92-9 Lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with IC50 of 11 nM.
CSN25434 Khellin 82-02-0 Khellin, a naturally occurring furochromone, is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects.
CSN24696 JND3229 2260886-64-2 JND3229 is a new highly potent EGFR(C797S) inhibitor with IC50 values of 5.8nM, 30.5nM and 6.8nM for EGFR (L858R/T790M/C797S), EGFR (T790M, L858R) and EGFR, respectively.
CSN24731 Idaein chloride 27661-36-5 Idaein chloride is a glycoside derivative of cyanidin, a potent inhibitor of EGFR, used in comparative analysis of anti-EGF activity in cancer cells.
CSN28785 EGFR-IN-5   2225887-26-1 EGFR-IN-5 is an inhibitor of EGFR with IC50 values of 10.4 nM, 1.1 nM, 34 nM and 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively. It could suppress EGFR phosphorylation in a dose-dependent manner in HCC827 cell line and significantly induce the apoptosis of HCC827 cells.
CSN25283 CGP 52411 145915-58-8 CGP 52411 inhibited the EGF-R protein-tyrosine kinase in vitro with high selectivity. In cells, CGP52411 selectively inhibited both ligand-induced EGF-R and p185c-erbB2 autophosphorylation and c-fos mRNA induction.
CSN10535 Canertinib 2HCl 289499-45-2 Canertinib 2HCl, an irreversible quinazoline-based HER family tyrosine kinase inhibitor, inhibits EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM respectively. Phase II.
CSN25556 BI-4020 2664214-60-0 BI-4020 is a noncovalent, new-generation, wild-type EGFR sparing, macrocyclic tyrosine kinase inhibitor.
CSN24709 AG-1557 189290-58-2 AG1557 is a specific EGFR tyrosine kinase inhibitor with pIC50 value of 8.194.
CSN25386 AG 1478 hydrochloride 170449-18-0 AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV).
CSN23735 AG 99 122520-85-8 AG 99 is an EGF receptor kinase inhibitor with IC50 of 10 µM in the human epidermoid carcinoma cell line A431.
CSN24707 AG 556 133550-41-1 AG 556 is an EGFR kinase inhibitor with IC50 value of 1.1μM, selective over ErbB2 (IC50 > 500 μM).
CSN28532 SJF 1528 2230821-38-0 Potent EGFR PROTAC®; also degrades HER2
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