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EGFR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN16336 | XL647 | 781613-23-8 | XL647 or tesevatinib inhibits EGFR, HER2, VEGFR and EphB4 with potential antineoplastic activity. |
| CSN22616 | NSC-228155 | 113104-25-9 | NSC228155 can enhance the tyrosine phosphorylation of EGFR via binding to the dimerization domain II. It blocks KIX-KID interaction as well (IC50 = 0.36 μM). |
| CSN20576 | Neratinib Maleate | 915942-22-2 | Neratinib maleate is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively. |
| CSN25720 | Methyl 2,5-dihydroxycinnamate | 63177-57-1 | Methyl 2,5-dihydroxycinnamate, the erbstatin analog, is an inhibitor of EGF receptor-associated tyrosine kinases. |
| CSN25434 | Khellin | 82-02-0 | Khellin, a naturally occurring furochromone, is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects. |
| CSN26106 | JCN037 | 2305154-31-6 | JCN037 is a potent EGFR inhibitor with IC50 values of 2.49 nM, 3.95 nM and 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively. It displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model. |
| CSN25621 | HS-10296 | 1899921-05-1 | HS-10296 is the third-generation EGFR TKIs which exhibited inhibitory effect on both EGFR-activating mutations and T790M-resistant mutation. |
| CSN19954 | Cyasterone | 17086-76-9 | Cyasterone is an inhibitor of EGFR that maybe a promising anti-cancer agent espcially in skin carcinoma. |
| CSN25283 | CGP 52411 | 145915-58-8 | CGP 52411 inhibited the EGF-R protein-tyrosine kinase in vitro with high selectivity. In cells, CGP52411 selectively inhibited both ligand-induced EGF-R and p185c-erbB2 autophosphorylation and c-fos mRNA induction. |
| CSN10535 | Canertinib 2HCl | 289499-45-2 | Canertinib 2HCl, an irreversible quinazoline-based HER family tyrosine kinase inhibitor, inhibits EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM respectively. Phase II. |
| CSN25556 | BI-4020 | N/A | BI-4020 is a noncovalent, new-generation, wild-type EGFR sparing, macrocyclic tyrosine kinase inhibitor. |
| CSN21119 | AG-494 | 133550-35-3 | AG-494 is an inhibitor of EGFR with an IC50 value of 0.7 µM and it is inactive toward ErbB2, PDGFR and insulin receptor kinase. |
| CSN23735 | AG 99 | 122520-85-8 | AG 99 is an EGF receptor kinase inhibitor with IC50 of 10 µM in the human epidermoid carcinoma cell line A431. |
| CSN21882 | AG 555 | 133550-34-2 | AG 555 is an inhibitor of epidermal growth factor receptor (EGFR) with IC50 of 0.7 μM. |
| CSN24709 | AG-1557 | 189290-58-2 |