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EGFR
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN11666 | Pelitinib | 257933-82-7 | Pelitinib irreversiblly inhibits EGFR with IC50 of 38.5 nM. |
CSN13798 | PD 158780 | 171179-06-9 | PD158780, a pyridopyrimidine derivative, is reversible inhibitor of ErbB receptor family (IC50s for EGFR, ErbB2 and ErbB2/ErbB4 are 0.008 nM, 49 nM and 52 nM respectively). |
CSN12357 | PD153035 | 153436-54-5 | PD153035 is EGFR inhibitor with Ki and IC50 of 5.2 pM and 29 pM and could rapidly suppress autophosphorylation of EGFR. |
CSN12700 | PD 153035 HCl | 183322-45-4 | PD153035 HCl is an reversible inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM. |
CSN13923 | N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide methanesulfonate | 1421373-66-1 | Osimertinib Mesylate is a selective inhibitor of mutant EGFR with IC50s of 12 nM and 1 nM for L858R and L858R/T790M in enzyme assay respectively. |
CSN13922 | N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide | 1421373-65-0 | Osimertinib is a potent and selective mutated forms EGFR inhibitor (Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM). |
CSN15680 | Desmethyl Erlotinib HCl | 183320-51-6 | OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM). |
CSN11268 | N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine | 231277-92-2 | Lapatinib is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. |
CSN12862 | Lapatinib ditosylate monohydrate | 388082-78-8 | Lapatinib Ditosylate Hydrate inhibits EGFR and ErbB2 with IC50 of 10.8 nM and 9.2 nM. |
CSN12937 | Icotinib HCl | 1204313-51-8 | Icotinib HCl is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an IC(50) of 5 nM, including it's mutants of EGFR (L858R), EGFR (L861Q), EGFR (T790M) and EGFR (T790M, L858R). |
CSN11084 | N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine | 184475-35-2 | Gefitinibis an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively, and interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. |
CSN11084 | N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine | 184475-35-2 | Gefitinibis an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively, and interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. |
CSN10931 | Erlotinib | 183321-74-6 | Erlotinib is an EGFR inhibitor with IC50 of 2 nM, > 1000-fold more sensitive for EGFR than human c-Src or v-Abl. |
CSN15847 | CUDC-101 | 1012054-59-9 | CUDC-101 inhibits HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM and 15.7 nM, respectively. |
CSN13912 | N-(3-((2-((4-(4-Acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide | 1374640-70-6 | CO-1686 functions as an irreversible and mutant-selective inhibitor of EGFRL858R/T790M and EGFRWT with Ki of 21.5 nM and 303.3 nM respectively. |
CSN12261 | Canertinib | 267243-28-7 | Canertinib is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. |
CSN10516 | Butein | 487-52-5 | Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR. |
CSN15747 | Falnidamol | 196612-93-8 | BIBX 1382 is a potent, selective inhibitor of EGFR tyrosine kinase (IC50 = 3 nM) and displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). |
CSN15755 | AZ-5104 | 1421373-98-9 | AZ5104 is an irreversible inhibitor of EGFR-L858R/T790M, EGFR-L858R, EGFR-L861Q, and EGFR (IC50s of < 1 nM, 6 nM, 1 nM, and 25 nM respectively). AZ5104 is the demethylated metabolite of AZD-9291. |
CSN10228 | AG 18 | 118409-57-7 | AG-18 is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 35 μM. |
CSN12358 | N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine | 153436-53-4 | AG-1478 selectively inhibits EGFR with IC50 of 3 nM in cell-free assay. |
CSN12371 | (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide | 439081-18-2 | Afatinib is an irreversible inhibitor of pan-ErbB inhibitor with IC50 values of 0.4nM, 0.5nM, 10nM, 14nM and 1nM for EGFR (L858R), EGFR (wt), EGFR (L858R/T790M), HER2 and ErbB4, respectively. |
CSN12385 | AEE788 | 497839-62-0 | AEE788 is an inhibitor of both EGFR and VEGFR, the IC50s for EGFR and ErbB2 is 2 nM, 6 nM respectively. |