Eukaryotic Initiation Factor | Cell Cycle| CSNpharm

eIF

eIF
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货号	产品名	CAS号	信息
CSN23286	SBI-0640756	2205871-61-8	SBI-0640756 is an inhibitor of eIF4G1 which can disrupt the function of eIF4F complex.
CSN18917	6-Chloro-3-[3-(5-fluoropyridin-3-yl)acryloyl]-4-phenyl-1H-quinolin-2-one	1997370-71-4	SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling.
CSN17259	Briciclib	865783-99-9	Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells.
CSN18206	4EGI-1	315706-13-9	4EGI-1 is an inhibitor of the cap-dependent translation initiation through disturbing the interaction between eIF4E and eIF4G, HNE1 cell line is the most sensitive one to 4EGI-1, and the IC50 of 4EGI-1 was about 50μM at 72h.
CSN19089	4E2RCat	432499-63-3	4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
CSN18215	4E1RCat	328998-25-0	4E1RCat blocks interaction between eIF4E:eIF4G and eIF4E:4E-BP1, prevents assembly of the eIF4F complex and inhibits cap-dependent translation with IC50 ~4 μM.
CSN26486	(Z)-4EGI-1	901787-88-0	(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2].
CSN67681	rel-Zotatifin	2098191-54-7