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Epac (or cAMPGEF) is cAMP-binding proteins first identified on the basis of its ability to stimulate the exchange of GDP for GTP at the guanyl nucleotide binding sites of the Rap1 and Rap2 small molecular weight G proteins and activates the Ras superfamily small GTPases Rap1 and Rap2.

Epac

货号 产品名 CAS号 信息
CSN18168 ESI-09 263707-16-0 ESI-09 is selective inhibitor of EPAC1 and EPAC2 with IC50 of 3.2 μM and 1.4 μM.
CSN25735 ESI 05 5184-64-5 ESI 05 is an inhibitor of EPAC2. It can inhibit cAMP binding to EPAC2 and cAMP mediated EPAC2 guanine nucleotide exchange factor (GEF) activity (IC50 = 0.4 μM).
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