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Epac (or cAMPGEF) is cAMP-binding proteins first identified on the basis of its ability to stimulate the exchange of GDP for GTP at the guanyl nucleotide binding sites of the Rap1 and Rap2 small molecular weight G proteins and activates the Ras superfamily small GTPases Rap1 and Rap2.

Epac

货号 产品名 CAS号 信息
CSN18795 HJC0350 885434-70-8 HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM.
CSN27217 HJC0197 1383539-73-8 HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP .
CSN18168 ESI-09 263707-16-0 ESI-09 is selective inhibitor of EPAC1 and EPAC2 with IC50 of 3.2 μM and 1.4 μM.
CSN25735 ESI-05 5184-64-5 ESI 05 is an inhibitor of EPAC2. It can inhibit cAMP binding to EPAC2 and cAMP mediated EPAC2 guanine nucleotide exchange factor (GEF) activity (IC50 = 0.4 μM).
CSN22395 EPAC 5376753 302826-61-5 EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.
CSN26361 CE3F4 143703-25-7 CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac), with IC50 values of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively.
CSN25734 8-CPT-2Me-cAMP sodium 634207-53-7 8-CPT-2Me-cAMP sodium salt is a selective activator of Epac.
CSN25733 (R)-CE3F4 1593478-56-8 (R)-CE3F4 is an inhibitor of Epac with IC50 values of 4.2 and 44 μM for Epac1 and Epac2(B), respectively.
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